The DOI matches its Crossref record; 59 of the 61 references it cites were found in a registry or an index.
CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
Open accessAbstract
After central nervous system (CNS) demyelination-such as occurs during multiple sclerosis-there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
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“A short time later (P120+7), 19.9% ± 3.2% of all optic nerve OPs (defined by NG2 immunolabeling) were YFP labeled (mean ±SD, n = 3 mice), less than in the adult corpus callosum (∼45%; Rivers et al., 2008) or spinal cord (∼39%; Zawadzka et al., 2010; Tripathi et al., 2010).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Zawadzka et al., 2010
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“The Cre/lox system been used in reporter mice to track oligodendrogenesis and myelin synthesis during development [45, 81], after CNS demyelination [82, 83], and after SCI [44, 84, 85].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [82]
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Cites
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Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Self-citationKessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195
Self-citationPDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Self-citationOligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells
Kondo, T., & RAFF, M. C. (2000) · Science · doi:10.1126/science.289.5485.1754 · Cited by 880
Remyelination is extensive in a subset of multiple sclerosis patients
Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709002105 · Cited by 789
Levison, S. W., & Goldman, J. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90311-e · Cited by 725
NG2 cells generate both oligodendrocytes and gray matter astrocytes
Zhu, X., Bergles, D. E., & Nishiyama, A. (2007) · Development · doi:10.1242/dev.004895 · Cited by 699
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Microglia promote remyelination independent of their role in clearing myelin debris
Baaklini, C. S., Ho, M. F. S., Lange, T., Hammond, B. P., Panda, S. P., Zirngibl, M., Zia, S., Himmelsbach, K., Rana, H., Phillips, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113574 · Cited by 73
Butti, E., Bacigaluppi, M., Chaabane, L., Ruffini, F., Brambilla, E., Berera, G., Montonati, C., Quattrini, A., & Martino, G. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0227-18.2019 · Cited by 67
Syed, Y. A., Baer, A., Hofer, M. P., González, G. A., Rundle, J., Myrta, S., Huang, J. K., Zhao, C., Rossner, M. J., Trotter, M. W. B., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201303123 · Cited by 58
Self-citationBaror, R., Neumann, B., Segel, M., Chalut, K. J., Fancy, S. P. J., Schafer, D. P., & Franklin, R. J. M. (2019) · Glia · doi:10.1002/glia.23612 · Cited by 54
Self-citationPentón-Rol, G., Marín-Prida, J., & Falcón-Cama, V. (2018) · Behavioral Sciences · doi:10.3390/bs8010015 · Cited by 50
Remyelination in the central nervous system
Franklin, R. J. M., Bodini, B., & Goldman, S. A. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041371 · Cited by 40
Self-citationMcMurran, C. E., Guzman de la Fuente, A., Penalva, R., Ben Menachem-Zidon, O., Dombrowski, Y., Falconer, J., Gonzalez, G. A., Zhao, C., Krause, F. N., Young, A. M. H., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905787116 · Cited by 39
Self-citationWylot, B., Mieczkowski, J., Niedziolka, S., Kaminska, B., & Zawadzka, M. (2019) · Cells · doi:10.3390/cells9010099 · Cited by 29
Self-citationAcute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination
Hou, J., Magliozzi, R., Chen, Y., Wu, J., Wulf, J., Strout, G., Fang, X., & Colonna, M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426786122 · Cited by 20
Pukos, N., & McTigue, D. M. (2020) · PLOS ONE · doi:10.1371/journal.pone.0235232 · Cited by 9
Metadata
- Authors
- Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., Rowitch, D. H., Kessaris, N., Suter, U., Richardson, W. D., & Franklin, R. J. M.
- Affiliations
- University College London (GB)
- Howard Hughes Medical Institute (US)
- University of Cambridge (GB)
- ETH Zurich (CH)
- Corresponding author
- Richardson, William D.
- Franklin, Robin J.M.
- ORCID
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 6
- Issue
- 6
- Pages
- 578-590
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3856868
- OpenAlex
- W2152131288
- Cited by
- 650
- References
- 61
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 35 · 2023: 40 · 2022: 38 · 2021: 39 · 2020: 56 · 2019: 53 · 2018: 49 · 2017: 56 · 2016: 34 · 2015: 35 · 2014: 49 · 2013: 46 · 2012: 33
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1178 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Wellcome Trust (080513)
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- central nervous system demyelination, remyelination, oligodendrocyte precursor cells, Schwann cells, glial progenitor cells, reactive astrocytes, multiple sclerosis, cell of origin, fate mapping
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Astrocytes, Cells, Cultured, Central Nervous System, Demyelinating Diseases, Disease Models, Animal, Female, Lysophosphatidylcholines, Mice, Transgenic, Microscopy, Multiple Sclerosis, Nerve Regeneration, Nerve Tissue Proteins, Oligodendroglia, Schwann Cells, Integrases, Receptor, Platelet-Derived Growth Factor alpha, Mice, Receptor, Fibroblast Growth Factor, Type 3, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Adult Stem Cells
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