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Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
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Citations
Cites
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Self-citationFitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007 · cited 2×
“…but also because more immature glia, such as radial glial cells, may have many other beneficial aspects, such as promoting neurite outgrowth and synapse formation, while scar-forming reactive astrocytes often inhibit it, thereby restricting rewiring after brain injury (Fitch and Silver, 2008).”
Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
Radde, R., Bolmont, T., Kaeser, S. A., Coomaraswamy, J., Lindau, D., Stoltze, L., Calhoun, M. E., Jäggi, F., Wolburg, H., Gengler, S., et al. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400784 · Cited by 986
Self-citationA Pericyte Origin of Spinal Cord Scar Tissue
Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O., & Frisén, J. (2011) · Science · doi:10.1126/science.1203165 · Cited by 858
Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Barnabé-Heider, F., Göritz, C., Sabelström, H., Takebayashi, H., Pfrieger, F. W., Meletis, K., & Frisén, J. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.014 · Cited by 628
Cruz, J. C., Tseng, H.-C., Goldman, J. A., Shih, H., & Tsai, L.-H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00627-5 · Cited by 609
Self-citationMori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398 · cited 4×
“At the dosage of tamoxifen used for fate mapping, this population consists mostly of astrocytes in the GM of the cerebral cortex (Figures S3A and S3B; Mori et al., 2006; Buffo et al., 2008; Robel et al., 2011b).”
InfluentialSelf-citationProliferating resident microglia after focal cerebral ischaemia in mice
Denes, A., Vidyasagar, R., Feng, J., Narvainen, J., McColl, B. W., Kauppinen, R. A., & Allan, S. M. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600495 · Cited by 342
Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219
Self-citation
Research works printed but not linked: 41
- Alvarez, 2011, The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence, Science, 334, 1727, 10.1126/science.1206936 · DOI · Paper page
- Amankulor, 2009, Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation, J. Neurosci., 29, 10299, 10.1523/JNEUROSCI.2500-09.2009 · DOI · Paper page
- Androutsellis-Theotokis, 2006, Notch signalling regulates stem cell numbers in vitro and in vivo, Nature, 442, 823, 10.1038/nature04940 · DOI · Paper page
- Antos, 2010, Vertebrates that regenerate as models for guiding stem cells, Adv. Exp. Med. Biol., 695, 184, 10.1007/978-1-4419-7037-4_13 · DOI
- Bambakidis, 2012, Improvement of neurological recovery and stimulation of neural progenitor cell proliferation by intrathecal administration of Sonic hedgehog, J. Neurosurg., 116, 1114, 10.3171/2012.1.JNS111285 · DOI
- Baumgart, 2012, Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis, Glia, 60, 343, 10.1002/glia.22269 · DOI · Paper page
- Bozoyan, 2012, Astrocytes control the development of the migration-promoting vasculature scaffold in the postnatal brain via VEGF signaling, J. Neurosci., 32, 1687, 10.1523/JNEUROSCI.5531-11.2012 · DOI
- Buffo, 2008, Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain, Proc. Natl. Acad. Sci. USA, 105, 3581, 10.1073/pnas.0709002105 · DOI · Paper page
- Chen, 2002, Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened, Genes Dev., 16, 2743, 10.1101/gad.1025302 · DOI · Paper page
- Cruz, 2006, p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo, J. Neurosci., 26, 10536, 10.1523/JNEUROSCI.3133-06.2006 · DOI · Paper page
- De Strooper, 1999, A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain, Nature, 398, 518, 10.1038/19083 · DOI · Paper page
- Duyckaerts, 2009, Classification and basic pathology of Alzheimer disease, Acta Neuropathol., 118, 5, 10.1007/s00401-009-0532-1 · DOI · Paper page
- El-Zaatari, 2012, Plasma Shh levels reduced in pancreatic cancer patients, Pancreas, 41, 1019, 10.1097/MPA.0b013e31824a0eeb · DOI
- Frank-Kamenetsky, 2002, Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists, J. Biol., 1, 10
- Gabay, 2003, Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro, Neuron, 40, 485, 10.1016/S0896-6273(03)00637-8 · DOI · Paper page
- Gadea, 2008, Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway, J. Neurosci., 28, 2394, 10.1523/JNEUROSCI.5652-07.2008 · DOI · Paper page
- Garcia, 2010, Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain, J. Neurosci., 30, 13597, 10.1523/JNEUROSCI.0830-10.2010 · DOI · Paper page
- Gates, 1995, Cell and molecular analysis of the developing and adult mouse subventricular zone of the cerebral hemispheres, J. Comp. Neurol., 361, 249, 10.1002/cne.903610205 · DOI · Paper page
- Hashimoto, 2008, Neuroprotective effect of sonic hedgehog up-regulated in Schwann cells following sciatic nerve injury, J. Neurochem., 107, 918, 10.1111/j.1471-4159.2008.05666.x · DOI
- Kroehne, 2011, Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors, Development, 138, 4831, 10.1242/dev.072587 · DOI · Paper page
- Lai, 2003, Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo, Nat. Neurosci., 6, 21, 10.1038/nn983 · DOI · Paper page
- Lang, 2004, Astrocytes in injured adult rat spinal cord may acquire the potential of neural stem cells, Neuroscience, 128, 775, 10.1016/j.neuroscience.2004.06.033 · DOI
- Long, 2001, Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation, Development, 128, 5099, 10.1242/dev.128.24.5099 · DOI · Paper page
- Machold, 2003, Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches, Neuron, 39, 937, 10.1016/S0896-6273(03)00561-0 · DOI · Paper page
- März, 2011, Regenerative response following stab injury in the adult zebrafish telencephalon, Dev. Dyn., 240, 2221, 10.1002/dvdy.22710 · DOI · Paper page
- Nakamura, 2006, Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system, Circ. Res., 98, 1547, 10.1161/01.RES.0000227505.19472.69 · DOI · Paper page
- Ohlig, 2011, Sonic hedgehog shedding results in functional activation of the solubilized protein, Dev. Cell, 20, 764, 10.1016/j.devcel.2011.05.010 · DOI
- Plesnila, 2004, Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia, J. Cereb. Blood Flow Metab., 24, 458, 10.1097/00004647-200404000-00011 · DOI · Paper page
- Robel, 2011, The stem cell potential of glia: lessons from reactive gliosis, Nat. Rev. Neurosci., 12, 88, 10.1038/nrn2978 · DOI · Paper page
- Robel, 2011, Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo, J. Neurosci., 30, 12471, 10.1523/JNEUROSCI.2696-11.2011 · DOI
- Rodríguez, 2009, Astroglia in dementia and Alzheimer’s disease, Cell Death Differ., 16, 378, 10.1038/cdd.2008.172 · DOI · Paper page
- Rupp, 2011, Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice, Neurobiol. Aging, 32, 10.1016/j.neurobiolaging.2010.08.014 · DOI
- Sehgal, 2009, BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression, Dev. Biol., 332, 429, 10.1016/j.ydbio.2009.05.579 · DOI
- Shimada, 2012, Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke, J. Neurosci., 32, 7926, 10.1523/JNEUROSCI.4303-11.2012 · DOI · Paper page
- Simon, 2011, Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury, Glia, 59, 869, 10.1002/glia.21156 · DOI · Paper page
- Sims, 2009, Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation, Stroke, 40, 3618, 10.1161/STROKEAHA.109.561951 · DOI
- Sirko, 2009, Focal laser-lesions activate an endogenous population of neural stem/progenitor cells in the adult visual cortex, Brain, 132, 2252, 10.1093/brain/awp043 · DOI
- Stoick-Cooper, 2007, Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine, Genes Dev., 21, 1292, 10.1101/gad.1540507 · DOI · Paper page
- Traiffort, 1999, Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system, Eur. J. Neurosci., 11, 3199, 10.1046/j.1460-9568.1999.00777.x · DOI · Paper page
- Tsuda, 2011, JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats, Brain, 134, 1127, 10.1093/brain/awr025 · DOI · Paper page
- Veeraraghavalu, 2010, Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling, J. Neurosci., 30, 6903, 10.1523/JNEUROSCI.0527-10.2010 · DOI
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Reactive astrocyte nomenclature, definitions, and future directions
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,513
Self-citationReactive Astrocytes: Production, Function, and Therapeutic Potential
Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336
Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
Burda, J. E., & Sofroniew, M. V. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.034 · Cited by 1,438
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Guo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., & Chen, G. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.001 · Cited by 832
Metadata
- Authors
- Sirko, S., Behrendt, G., Johansson, P. A., Tripathi, P., Costa, M. R., Bek, S., Heinrich, C., Tiedt, S., Colak, D., Dichgans, M., Fischer, I. R., Plesnila, N., Staufenbiel, M., Haass, C., Snapyan, M., Saghatelyan, A., Tsai, L.-H., Fischer, A., Grobe, K., Dimou, L., & Götz, M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 12
- Issue
- 4
- Pages
- 426-439
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2128229230
- Cited by
- 381
- References
- 13
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-05-02)
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
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- The paper
- Sirko, S., Behrendt, G., Johansson, P. A., Tripathi, P., Costa, M. R., Bek, S., Heinrich, C., Tiedt, S., Colak, D., Dichgans, M., Fischer, I. R., Plesnila, N., Staufenbiel, M., Haass, C., Snapyan, M., Saghatelyan, A., Tsai, L.-H., Fischer, A., Grobe, K., . . . Götz, M. (2013). Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog. Cell Stem Cell. https://doi.org/10.1016/j.stem.2013.01.019
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