Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

Gibson, D. G., Glass, J. I., Lartigue, C., Noskov, V. N., Chuang, R.-Y., Algire, M. A., Benders, G. A., Montague, M. G., Ma, L., Moodie, M. M., et al. (2010) · Science · doi:10.1126/science.1190719 · Cited by 2,638

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

Ajikumar, P. K., Xiao, W.-H., Tyo, K. E. J., Wang, Y., Simeon, F., Leonard, E., Mucha, O., Phon, T. H., Pfeifer, B., & Stephanopoulos, G. (2010) · Science · doi:10.1126/science.1191652 · Cited by 1,677

A Whole-Cell Computational Model Predicts Phenotype from Genotype

Karr, J. R., Sanghvi, J. C., Macklin, D. N., Gutschow, M. V., Jacobs, J. M., Bolival, B., Assad-Garcia, N., Glass, J. I., & Covert, M. W. (2012) · Cell · doi:10.1016/j.cell.2012.05.044 · Cited by 1,300 · cited 1×

Synthetic protein scaffolds provide modular control over metabolic flux

Dueber, J. E., Wu, G. C., Malmirchegini, G. R., Moon, T. S., Petzold, C. J., Ullal, A. V., Prather, K. L. J., & Keasling, J. D. (2009) · Nature Biotechnology · doi:10.1038/nbt.1557 · Cited by 1,242

Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110

Varma, A., & Palsson, B. O. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.10.3724-3731.1994 · Cited by 1,051

Energetics of bacterial growth: balance of anabolic and catabolic reactions

Russell, J. B., & Cook, G. M. (1995) · Microbiological Reviews · doi:10.1128/mr.59.1.48-62.1995 · Cited by 927

Rescuing US biomedical research from its systemic flaws

Alberts, B., Kirschner, M. W., Tilghman, S., & Varmus, H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404402111 · Cited by 817 · cited 1×

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

Zhang, F., Carothers, J. M., & Keasling, J. D. (2012) · Nature Biotechnology · doi:10.1038/nbt.2149 · Cited by 816

Integrated Electromicrobial Conversion of CO 2 to Higher Alcohols

Li, H., Opgenorth, P. H., Wernick, D. G., Rogers, S., Wu, T.-Y., Higashide, W., Malati, P., Huo, Y.-X., Cho, K. M., & Liao, J. C. (2012) · Science · doi:10.1126/science.1217643 · Cited by 749

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

Zhou, K., Qiao, K., Edgar, S., & Stephanopoulos, G. (2015) · Nature Biotechnology · doi:10.1038/nbt.3095 · Cited by 710

Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis

Akashi, H., & Gojobori, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062526999 · Cited by 665

Metabolic load and heterologous gene expression

Glick, B. R. (1995) · Biotechnology Advances · doi:10.1016/0734-9750(95)00004-a · Cited by 663

Metabolic networks in motion: 13 C‐based flux analysis

Sauer, U. (2006) · Molecular Systems Biology · doi:10.1038/msb4100109 · Cited by 660

A roadmap for interpreting 13C metabolite labeling patterns from cells

Buescher, J. M., Antoniewicz, M. R., Boros, L. G., Burgess, S. C., Brunengraber, H., Clish, C. B., DeBerardinis, R. J., Feron, O., Frezza, C., Ghesquiere, B., et al. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.02.003 · Cited by 629

Systems strategies for developing industrial microbial strains

Lee, S. Y., & Kim, H. U. (2015) · Nature Biotechnology · doi:10.1038/nbt.3365 · Cited by 589

Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

Avalos, J. L., Fink, G. R., & Stephanopoulos, G. (2013) · Nature Biotechnology · doi:10.1038/nbt.2509 · Cited by 517

OptStrain: A computational framework for redesign of microbial production systems

Pharkya, P., Burgard, A. P., & Maranas, C. D. (2004) · Genome Research · doi:10.1101/gr.2872004 · Cited by 497

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control

Xu, P., Li, L., Zhang, F., Stephanopoulos, G., & Koffas, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406401111 · Cited by 487

Engineering dynamic pathway regulation using stress-response promoters

Dahl, R. H., Zhang, F., Alonso-Gutierrez, J., Baidoo, E., Batth, T. S., Redding-Johanson, A. M., Petzold, C. J., Mukhopadhyay, A., Lee, T. S., Adams, P. D., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2689 · Cited by 473

Genome‐scale models of metabolism and gene expression extend and refine growth phenotype prediction

O'Brien, E. J., Lerman, J. A., Chang, R. L., Hyduke, D. R., & Palsson, B. Ø. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.52 · Cited by 471

Modular optimization of multi-gene pathways for fatty acids production in E. coli

Xu, P., Gu, Q., Wang, W., Wong, L., Bower, A. G. W., Collins, C. H., & Koffas, M. A. G. (2013) · Nature Communications · doi:10.1038/ncomms2425 · Cited by 460

Towards synthesis of a minimal cell

Forster, A. C., & Church, G. M. (2006) · Molecular Systems Biology · doi:10.1038/msb4100090 · Cited by 442

Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli

Pitera, D. J., Paddon, C. J., Newman, J. D., & Keasling, J. D. (2007) · Metabolic Engineering · doi:10.1016/j.ymben.2006.11.002 · Cited by 438

OptForce: An Optimization Procedure for Identifying All Genetic Manipulations Leading to Targeted Overproductions

Ranganathan, S., Suthers, P. F., & Maranas, C. D. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000744 · Cited by 417

Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae

Wijffels, R. H., Kruse, O., & Hellingwerf, K. J. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.04.004 · Cited by 403

Engineering Escherichia coli coculture systems for the production of biochemical products

Zhang, H., Pereira, B., Li, Z., & Stephanopoulos, G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506781112 · Cited by 324

Stabilized gene duplication enables long-term selection-free heterologous pathway expression

Tyo, K. E. J., Ajikumar, P. K., & Stephanopoulos, G. (2009) · Nature Biotechnology · doi:10.1038/nbt.1555 · Cited by 310

Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli

Moon, T. S., Dueber, J. E., Shiue, E., & Prather, K. L. J. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2010.01.003 · Cited by 296

Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene

Anthony, J. R., Anthony, L. C., Nowroozi, F., Kwon, G., Newman, J. D., & Keasling, J. D. (2009) · Metabolic Engineering · doi:10.1016/j.ymben.2008.07.007 · Cited by 292

Metabolic Engineering: Past and Future

Woolston, B. M., Edgar, S., & Stephanopoulos, G. (2013) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061312-103312 · Cited by 292

Impact of Global Transcriptional Regulation by ArcA, ArcB, Cra, Crp, Cya, Fnr, and Mlc on Glucose Catabolism in Escherichia coli

Perrenoud, A., & Sauer, U. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.9.3171-3179.2005 · Cited by 280

Minimal Escherichia coli Cell for the Most Efficient Production of Ethanol from Hexoses and Pentoses

Trinh, C. T., Unrean, P., & Srienc, F. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02708-07 · Cited by 278

In silico method for modelling metabolism and gene product expression at genome scale

Lerman, J. A., Hyduke, D. R., Latif, H., Portnoy, V. A., Lewis, N. E., Orth, J. D., Schrimpe-Rutledge, A. C., Smith, R. D., Adkins, J. N., Zengler, K., et al. (2012) · Nature Communications · doi:10.1038/ncomms1928 · Cited by 266

ePathBrick: A Synthetic Biology Platform for Engineering Metabolic Pathways in E. coli

Xu, P., Vansiri, A., Bhan, N., & Koffas, M. A. G. (2012) · ACS Synthetic Biology · doi:10.1021/sb300016b · Cited by 255

Proteorhodopsins: an array of physiological roles?

Fuhrman, J. A., Schwalbach, M. S., & Stingl, U. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1893 · Cited by 245

Harnessing yeast subcellular compartments for the production of plant terpenoids

Farhi, M., Marhevka, E., Masci, T., Marcos, E., Eyal, Y., Ovadis, M., Abeliovich, H., & Vainstein, A. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.05.001 · Cited by 245

An Enzymic Analysis of NADPH Production and Consumption in Candida utilis

Bruinenberg, P. M., Van Dijken, J. P., & Scheffers, W. A. (1983) · Microbiology · doi:10.1099/00221287-129-4-965 · Cited by 243

Genome Engineering Reveals Large Dispensable Regions in Bacillus subtilis

Westers, H. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg219 · Cited by 231

Computational tools for the synthetic design of biochemical pathways

Medema, M. H., van Raaphorst, R., Takano, E., & Breitling, R. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2717 · Cited by 226

Toward Homosuccinate Fermentation: Metabolic Engineering of Corynebacterium glutamicum for Anaerobic Production of Succinate from Glucose and Formate

Litsanov, B., Brocker, M., & Bott, M. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.07790-11 · Cited by 223

Light-powering Escherichia coli with proteorhodopsin

Walter, J. M., Greenfield, D., Bustamante, C., & Liphardt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611035104 · Cited by 222

Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering

Chemler, J. A., Fowler, Z. L., McHugh, K. P., & Koffas, M. A. G. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2009.07.003 · Cited by 219

Energy Starved Candidatus Pelagibacter Ubique Substitutes Light-Mediated ATP Production for Endogenous Carbon Respiration

Steindler, L., Schwalbach, M. S., Smith, D. P., Chan, F., & Giovannoni, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019725 · Cited by 215

Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay

Lee, M. E., Aswani, A., Han, A. S., Tomlin, C. J., & Dueber, J. E. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt809 · Cited by 213

Proteorhodopsin photosystem gene expression enables photophosphorylation in a heterologous host

Martinez, A., Bradley, A. S., Waldbauer, J. R., Summons, R. E., & DeLong, E. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611470104 · Cited by 207

Economics of membrane occupancy and respiro‐fermentation

Zhuang, K., Vemuri, G. N., & Mahadevan, R. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.34 · Cited by 203

Increased Malonyl Coenzyme A Biosynthesis by Tuning the Escherichia coli Metabolic Network and Its Application to Flavanone Production

Fowler, Z. L., Gikandi, W. W., & Koffas, M. A. G. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00270-09 · Cited by 202

Building outside of the box: iGEM and the BioBricks Foundation

Smolke, C. D. (2009) · Nature Biotechnology · doi:10.1038/nbt1209-1099 · Cited by 190

From the first drop to the first truckload: commercialization of microbial processes for renewable chemicals

Van Dien, S. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.03.002 · Cited by 187

Plasmid presence changes the relative levels of many host cell proteins and ribosome components in recombinant Escherichia coli

Birnbaum, S., & Bailey, J. E. (1991) · Biotechnology and Bioengineering · doi:10.1002/bit.260370808 · Cited by 185

Genome-scale reconstruction of Escherichia coli's transcriptional and translational machinery: a knowledge base, its mathematical formulation, and its functional characterization

Thiele, I., Jamshidi, N., Fleming, R. M. T., & Palsson, B. Ø. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000312 · Cited by 182 · cited 1×

Rational design of a synthetic Entner–Doudoroff pathway for improved and controllable NADPH regeneration

Ng, C. Y., Farasat, I., Maranas, C. D., & Salis, H. M. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.03.001 · Cited by 167

Dynamic knockdown of E. coli central metabolism for redirecting fluxes of primary metabolites

Brockman, I. M., & Prather, K. L. J. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2014.12.005 · Cited by 164

CRISPathBrick: Modular Combinatorial Assembly of Type II-A CRISPR Arrays for dCas9-Mediated Multiplex Transcriptional Repression in E. coli

Cress, B. F., Toparlak, Ö. D., Guleria, S., Lebovich, M., Stieglitz, J. T., Englaender, J. A., Jones, J. A., Linhardt, R. J., & Koffas, M. A. G. (2015) · ACS Synthetic Biology · doi:10.1021/acssynbio.5b00012 · Cited by 163

ePathOptimize: A Combinatorial Approach for Transcriptional Balancing of Metabolic Pathways

Jones, J. A., Vernacchio, V. R., Lachance, D. M., Lebovich, M., Fu, L., Shirke, A. N., Schultz, V. L., Cress, B. F., Linhardt, R. J., & Koffas, M. A. G. (2015) · Scientific Reports · doi:10.1038/srep11301 · Cited by 159

A feeling for the numbers in biology

Phillips, R., & Milo, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907732106 · Cited by 148

Production of chondroitin in metabolically engineered E. coli

He, W., Fu, L., Li, G., Jones, J. A., Linhardt, R. J., & Koffas, M. A. G. (2014) · Metabolic Engineering · doi:10.1016/j.ymben.2014.11.003 · Cited by 145

Improvement of catechin production in Escherichia coli through combinatorial metabolic engineering

Zhao, S., Jones, J. A., Lachance, D. M., Bhan, N., Khalidi, O., Venkataraman, S. K., Wang, Z., & Koffas, M. A. G. (2014) · Metabolic Engineering · doi:10.1016/j.ymben.2014.12.002 · Cited by 141

Metabolic engineering of

Lin, Z., Xu, Z., Li, Y., Wang, Z., Chen, T., & Zhao, X. (2014) · Microbial Cell Factories · doi:10.1186/s12934-014-0104-5 · Cited by 136

Synergy between 13C-metabolic flux analysis and flux balance analysis for understanding metabolic adaption to anaerobiosis in E. coli

Chen, X., Alonso, A. P., Allen, D. K., Reed, J. L., & Shachar‐Hill, Y. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2010.11.004 · Cited by 133

Central metabolic responses to the overproduction of fatty acids in Escherichia coli based on 13 C‐metabolic flux analysis

He, L., Xiao, Y., Gebreselassie, N. A., Zhang, F., Antoniewicz, M. R., Tang, Y., & Peng, L. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.25124 · Cited by 124

Yeast fermentation of carboxylic acids obtained from pyrolytic aqueous phases for lipid production

Lian, J., Garcı̀a-Pèrez, M., Coates, R., et al. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.05.010 · Cited by 122

Expression of Intracellular Hemoglobin Improves Protein Synthesis in Oxygen-Limited Escherichia coli

Khosla, C., Curtis, J. E., DeModena, J. A., Rinas, U., & Bailey, J. E. (1990) · Nature Biotechnology · doi:10.1038/nbt0990-849 · Cited by 114

Simultaneous utilization of glucose and xylose via novel mechanisms in engineered Escherichia coli

Kim, S. M., Choi, B. Y., Ryu, Y. S., Jung, S. H., Park, J. M., Kim, G.-H., & Lee, S. K. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.05.002 · Cited by 112

Metabolic engineering of Escherichia coli to minimize byproduct formate and improving succinate productivity through increasing NADH availability by heterologous expression of NAD+-dependent formate dehydrogenase

Balzer, G. J., Thakker, C., Bennett, G. N., & San, K. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2013.07.005 · Cited by 111

Advancing metabolic models with kinetic information

Link, H., Christodoulou, D., & Sauer, U. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.01.015 · Cited by 109

Multiscale Modeling of Metabolism and Macromolecular Synthesis in E. coli and Its Application to the Evolution of Codon Usage

Thiele, I., Fleming, R. M. T., Que, R. A., Bordbar, A., Diep, D. H., & Palsson, B. Ø. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045635 · Cited by 109

Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly

Nowroozi, F. F., Baidoo, E. E. K., Ermakov, S., Redding‐Johanson, A. M., Batth, T. S., Petzold, C. J., & Keasling, J. D. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5361-4 · Cited by 107

Engineering E. coli–E. coli cocultures for production of muconic acid from glycerol

Zhang, H., Li, Z., Pereira, B., & Stephanopoulos, G. N. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0319-0 · Cited by 106

Redesigning Escherichia coli Metabolism for Anaerobic Production of Isobutanol

Trinh, C. T., Li, J., Blanch, H. W., & Clark, D. S. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.00382-11 · Cited by 106

Cost-Benefit Tradeoffs in Engineered lac Operons

Eames, M., & Kortemme, T. (2012) · Science · doi:10.1126/science.1219083 · Cited by 99

13C metabolic flux analysis at a genome-scale

Gopalakrishnan, S., & Maranas, C. D. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.08.006 · Cited by 95

Potential production platform of n-butanol in Escherichia coli

Saini, M. K., Chen, M. H., Chiang, C., & Chao, Y. (2014) · Metabolic Engineering · doi:10.1016/j.ymben.2014.11.001 · Cited by 92

Butyrate production in engineered Escherichia coli with synthetic scaffolds

Baek, J., Mazumdar, S., Lee, S., Jung, M.-Y., Lim, J. H., Seo, S. W., Jung, G., & Oh, M. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.24925 · Cited by 91

Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by Bacillus subtilis

Liu, Y., Zhu, Y., Ma, W., Shin, H., Li, J., Liu, L., Du, G., & Chen, J. (2014) · Metabolic Engineering · doi:10.1016/j.ymben.2014.04.004 · Cited by 90

Novel Multiscale Modeling Tool Applied to Pseudomonas aeruginosa Biofilm Formation

Biggs, M. B., & Papin, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078011 · Cited by 88

Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae

Latimer, L. N., Lee, M. E., Medina-Cleghorn, D., Kohnz, R. A., Nomura, D. K., & Dueber, J. E. (2014) · Metabolic Engineering · doi:10.1016/j.ymben.2014.06.002 · Cited by 78

Quantification of metabolic limitations during recombinant protein production in Escherichia coli

Heyland, J., Blank, L. M., & Schmid, A. B. (2011) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2011.06.016 · Cited by 76

Metabolic Characterization of Escherichia coli Strains Adapted to Growth on Lactate

Hua, Q., Joyce, A. R., Palsson, B. Ø., & Fong, S. S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00527-07 · Cited by 67

Redirecting carbon flux into malonyl-CoA to improve resveratrol titers: Proof of concept for genetic interventions predicted by OptForce computational framework

Bhan, N., Xu, P., Khalidi, O., & Koffas, M. A. G. (2012) · Chemical Engineering Science · doi:10.1016/j.ces.2012.10.009 · Cited by 67

Photoheterotrophic Fluxome in Synechocystis sp. Strain PCC 6803 and Its Implications for Cyanobacterial Bioenergetics

You, L., He, L., & Tang, Y. (2014) · Journal of Bacteriology · doi:10.1128/jb.02149-14 · Cited by 65

A Method to Constrain Genome-Scale Models with 13C Labeling Data

Martín, H. G., Kumar, V. S., Weaver, D. S., Ghosh, A., Chubukov, V., Mukhopadhyay, A., Arkin, A. P., & Keasling, J. D. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004363 · Cited by 63

Role of Cytochrome bd Oxidase from Corynebacterium glutamicum in Growth and Lysine Production

Kabus, A., Niebisch, A., & Bott, M. H. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01818-06 · Cited by 63

Light-energy conversion in engineered microorganisms

Johnson, E. T., & Schmidt‐Dannert, C. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.09.002 · Cited by 53

An ancient Chinese wisdom for metabolic engineering: Yin-Yang

Wu, S. G., He, L., Wang, Q., & Tang, Y. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0219-3 · Cited by 52

WholeCellKB: model organism databases for comprehensive whole-cell models

Karr, J. R., Sanghvi, J. C., Macklin, D. N., Arora, A., & Covert, M. W. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1108 · Cited by 49

Estimation of P-to-O ratio inBacillus subtilis and its influence on maximum riboflavin yield

Sauer, U., & Bailey, J. E. (1999) · Biotechnology and Bioengineering · Cited by 42

Biological consequences of plasmid transformation of the plant growth promoting rhizobacterium Pseudomonas putida GR12-2

Hong, Y., Pasternak, J. J., & Glick, B. R. (1991) · Canadian Journal of Microbiology · doi:10.1139/m91-137 · Cited by 33

Evaluating Factors That Influence Microbial Synthesis Yields by Linear Regression with Numerical and Ordinal Variables

Colletti, P. F., Goyal, Y., Varman, A. M., Feng, X., Wu, B., & Tang, Y. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22996 · Cited by 31

The iGEM competition: building with biology

Brown, J. R. (2007) · IET Synthetic Biology · doi:10.1049/iet-stb:20079020 · Cited by 25

Statistics-based model for prediction of chemical biosynthesis yield from Saccharomyces cerevisiae

Varman, A. M., Xiao, Y., Leonard, E., & Tang, Y. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-45 · Cited by 24

Correlation Between Proton Translocation and Growth: Genetic Analysis of the Respiratory Chain of Corynebacterium glutamicum

Kabashima, Y., Kishikawa, J.-I., Kurokawa, T., & Sakamoto, J. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp140 · Cited by 23

A fundamental regulatory role of formate on thuringiensin production by resting cell of Bacillus thuringiensis YBT-032

Wang, Z., Chen, S., Lifang, R., Ming, S., & Ziniu, Y. (2007) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-007-0118-z · Cited by 4

Synthetic Biology Tools to Engineer Microbial Communities for Biotechnology

McCarty, N. S., & Ledesma-Amaro, R. (2019) · Trends in Biotechnology · doi:10.1016/j.tibtech.2018.11.002 · Cited by 578

Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology.

Bervoets, I., & Charlier, D. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz001 · Cited by 180

Synthetic microbial consortia for biosynthesis and biodegradation: promises and challenges

Che, S., & Men, Y. (2019) · Journal of Industrial Microbiology and Biotechnology · doi:10.1007/s10295-019-02211-4 · Cited by 177

Engineering the Oleaginous Yeast Yarrowia Lipolytica to Produce the Aroma Compound β-Ionone

Czajka, J. J., Nathenson, J. A., Benites, V. T., Baidoo, E. E. K., Cheng, Q., Wang, Y., & Tang, Y. J. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0984-x · Cited by 109

Recent advances of biofuels and biochemicals production from sustainable resources using co-cultivation systems

Jiang, Y., Wu, R., Zhou, J., He, A., Xu, J., Xin, F., Zhang, W., Ma, J., Jiang, M., & Dong, W. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1495-7 · Cited by 93