Does the microbiota regulate immune responses outside the gut?

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

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Bacterial contributions to mammalian gut development

Hooper, L. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.01.001 · Cited by 541

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.12.012 · Cited by 3,119

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910

Influence of diet on the gut microbiome and implications for human health

Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

Zhu, L., Baker, S. S., Gill, C., Liu, W., Alkhouri, R., Baker, R. D., & Gill, S. R. (2013) · Hepatology · doi:10.1002/hep.26093 · Cited by 1,708

Diet, gut microbiota and immune responses

Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261

Long-term ecological impacts of antibiotic administration on the human intestinal microbiota

Jernberg, C., Löfmark, S., Edlund, C., & Jansson, J. K. (2007) · The ISME Journal · doi:10.1038/ismej.2007.3 · Cited by 1,134

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

Clarke, T. B., Davis, K. M., Lysenko, E. S., Zhou, A. Y., Yu, Y., & Weiser, J. N. (2010) · Nature Medicine · doi:10.1038/nm.2087 · Cited by 1,154

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

Leclercq, S., Matamoros, S., Cani, P. D., Neyrinck, A. M., Jamar, F., Stärkel, P., Windey, K., Tremaroli, V., Bäckhed, F., Verbeke, K., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415174111 · Cited by 972

Bile acid signaling in metabolic disease and drug therapy

Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935

Diet, metabolites, and “western-lifestyle” inflammatory diseases

Thorburn, A. N., Macia, L., & Mackay, C. R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.014 · Cited by 879

Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study

Penders, J., Thijs, C., van den Brandt, P. A., Kummeling, I., Snijders, B., Stelma, F., Adams, H., van Ree, R., & Stobberingh, E. E. (2007) · Gut · doi:10.1136/gut.2006.100164 · Cited by 844

The Gut Microbiota Plays a Protective Role in the Host Defence Against Pneumococcal Pneumonia

Schuijt, T. J., Lankelma, J. M., Scicluna, B. P., de Sousa e Melo, F., Roelofs, J. J. T. H., de Boer, J. D., Hoogendijk, A. J., de Beer, R., de Vos, A., Belzer, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309728 · Cited by 832

Fecal microbiota transplantation and emerging applications

Borody, T. J., & Khoruts, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.244 · Cited by 677

Diversity of the human gastrointestinal tract microbiota revisited

Rajilić‐Stojanović, M., Smidt, H., & De Vos, W. M. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01369.x · Cited by 559

Assembly of the human intestinal microbiota

Dethlefsen, L., Eckburg, P. B., Bik, E. M., & Relman, D. A. (2006) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2006.06.013 · Cited by 509

Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota

Ganal, S. C., Sanos, S. L., Kallfass, C., Oberle, K., Johner, C., Kirschning, C., Lienenklaus, S., Weiss, S., Staeheli, P., Aichele, P., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.020 · Cited by 484

Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis

Song, H., Yoo, Y., Hwang, J., Na, Y.-C., & Kim, H. S. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.021 · Cited by 416

The ‘microflora hypothesis’ of allergic diseases

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NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings

Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370

Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients

Kerckhoffs, A. P., Samsom, M., Rest, M. E. V. D., Vogel, J. D., Knol, J., Ben-Amor, K., & Akkermans, L. M. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.2887 · Cited by 289

Ageing: from inflammation to cancer

Leonardi, G. C., Accardi, G., Monastero, R., Nicoletti, F., & Libra, M. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0112-5 · Cited by 241

ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer’s patches to promote host-microbiota mutualism

Proietti, M., Cornacchione, V., Rezzonico Jost, T., Romagnani, A., Faliti, C. E., Perruzza, L., Rigoni, R., Radaelli, E., Caprioli, F., Preziuso, S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.010 · Cited by 181

Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health

Albers, R., Bourdet-Sicard, R., Braun, D., Calder, P. C., Herz, U., Lambert, C., Lenoir-Wijnkoop, I., Méheust, A., Ouwehand, A., Phothirath, P., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114513001505 · Cited by 150

Human helminth therapy to treat inflammatory disorders—where do we stand?

Helmby, H. (2015) · BMC Immunology · doi:10.1186/s12865-015-0074-3 · Cited by 140

Gut Microbiota Regulates Mincle Mediated Activation of Lung Dendritic Cells to Protect Against Mycobacterium tuberculosis

Negi, S., Pahari, S., Bashir, H., & Agrewala, J. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01142 · Cited by 116

Health effects of probiotics on the skin

Roudsari, M. R., Karimi, R., Sohrabvandi, S., & Mortazavian, A. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.680078 · Cited by 113

The Role of Oral Hygiene in Inflammatory Bowel Disease

Singhal, S., Dian, D., Keshavarzian, A., Fogg, L., Fields, J. Z., & Farhadi, A. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1263-9 · Cited by 68

Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms

Ottaviani, E., Ventura, N., Mandrioli, M., Candela, M., Franchini, A., & Franceschi, C. (2011) · Biogerontology · doi:10.1007/s10522-011-9352-5 · Cited by 64

Effects of organically and conventionally produced feed on biomarkers of health in a chicken model

Huber, M., van de Vijver, L. P. L., Parmentier, H., Savelkoul, H., Coulier, L., Wopereis, S., Verheij, E., van der Greef, J., Nierop, D., & Hoogenboom, R. A. P. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509992236 · Cited by 55

Role of Microbiome in Regulating the HPA Axis and Its Relevance to Allergy

Sudo, N. (2012) · Chemical Immunology and Allergy · doi:10.1159/000336510 · Cited by 54

The cross-talk between opportunistic fungi and the mammalian host via microbiota’s metabolism

Romani, L., Zelante, T., Palmieri, M., Napolioni, V., Picciolini, M., Velardi, A., Aversa, F., & Puccetti, P. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0464-2 · Cited by 47

Probiotics in Children

Kligler, B., Hanaway, P., & Cohrssen, A. (2007) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2007.10.002 · Cited by 41

The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases

Gonçalves, S. M., Lagrou, K., Duarte-Oliveira, C., Maertens, J. A., Cunha, C., & Carvalho, A. (2017) · Virulence · doi:10.1080/21505594.2016.1257458 · Cited by 32

Cold‐inflammaging: When a state of homeostatic‐imbalance associated with aging precedes the low‐grade pro‐inflammatory‐state (inflammaging): Meaning, evolution, inflammaging phenotypes

Giunta, S., Wei, Y., Xu, K., & Xia, S. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13686 · Cited by 27

Factors associated with Allergic Rhinitis in Colombian subpopulations aged 1 to 17 and 18 to 59

Penaranda, A., Garcia, E., Barragan, A. M., Rondon, M. A., Perez, A., Rojas, M. X., Caraballo, L., & Dennis, R. J. (2016) · Rhinology journal · doi:10.4193/rhin14.234 · Cited by 13