Cited by 357Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersAmino Acid Enzymes and Metabolism

The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.

Homeostatic plasticity and NMDA receptor trafficking

Pérez-Otaño, Isabel, Ehlers, Michael D.·2005·Trends in Neurosciences

DOI 10.1016/j.tins.2005.03.004

Open this paper in CoChat — free account

Abstract

Learning, memory and brain development are associated with long-lasting modifications of synapses that are guided by specific patterns of neuronal activity. Such modifications include classical Hebbian plasticities (such as long-term potentiation and long-term depression), which are rapid and synapse-specific, and others, such as synaptic scaling and metaplasticity, that work over longer timescales and are crucial for maintaining and orchestrating neuronal network function. The cellular mechanisms underlying Hebbian plasticity have been well studied and involve rapid changes in the trafficking of highly mobile AMPA receptors. An emerging concept is that activity-dependent alterations in NMDA receptor trafficking contribute to homeostatic plasticity at central glutamatergic synapses.

Integrity signals

Registry

Crossref · 10.1016/j.tins.2005.03.004

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917
Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex
Bienenstock, E., Cooper, L., & Munro, P. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00032.1982 · Cited by 2,896
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,878
Metaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,833
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686
The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein
Cho, K.-O., Hunt, C. A., & Kennedy, M. B. (1992) · Neuron · doi:10.1016/0896-6273(92)90245-9 · Cited by 1,188
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity
Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004) · Science · doi:10.1126/science.1096615 · Cited by 1,131
A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127
CLIP Identifies Nova-Regulated RNA Networks in the Brain
Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science · doi:10.1126/science.1090095 · Cited by 1,120
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Self-citation
Calcium regulation of neuronal gene expression
West, A. E., Chen, W., Dalva, M. B., Dolmetsch, R. E., Kornhauser, J. M., Shaywitz, A. J., Takasu, M. A., Xu, T., & Greenberg, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191352298 · Cited by 1,047
Learning-Induced LTP in Neocortex
Rioult-Pedotti, M.-S., Friedman, D. J., & Donoghue, J. P. (2000) · Science · doi:10.1126/science.290.5491.533 · Cited by 1,014
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977
Self-citation
Role of Distinct NMDA Receptor Subtypes at Central Synapses
Cull-Candy, S. G., & Leszkiewicz, D. N. (2004) · Science s STKE · doi:10.1126/stke.2552004re16 · Cited by 796
Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities.
Carlin, R. K., Grab, D. J., Cohen, R. S., & Siekevitz, P. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.86.3.831 · Cited by 788
The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal Synapses In Vitro
Tovar, K. R., & Westbrook, G. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04180.1999 · Cited by 777
Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex
Carmignoto, G., & Vicini, S. (1992) · Science · doi:10.1126/science.1279803 · Cited by 721
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression
Massey, P. V., Johnson, B. E., Moult, P. R., Auberson, Y. P., Brown, M. W., Molnár, E., Collingridge, G. L., & Bashir, Z. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1697-04.2004 · Cited by 712
A critical period for long-term potentiation at thalamocortical synapses
Crair, M. C., & Malenka, R. C. (1995) · Nature · doi:10.1038/375325a0 · Cited by 691
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688
Self-citation
Experience-dependent modification of synaptic plasticity in visual cortex
Kirkwood, A., Rioult, M., & Bear, M. (1996) · Nature · doi:10.1038/381526a0 · Cited by 666
Synaptic plasticity and dynamic modulation of the postsynaptic membrane
Lüscher, C., Nicoll, R. A., Malenka, R. C., & Müller, D. (2000) · Nature Neuroscience · doi:10.1038/75714 · Cited by 662
SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
Kim, J. H., Liao, D., Lau, L.-F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)81008-9 · Cited by 634
NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex
Flint, A. C., Maisch, U. S., Weishaupt, J. H., Kriegstein, A. R., & Monyer, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02469.1997 · Cited by 623
A unified model of NMDA receptor-dependent bidirectional synaptic plasticity
Shouval, H. Z., Bear, M. F., & Cooper, L. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152343099 · Cited by 613
Inactivity produces increases in neurotransmitter release and synapse size
Murthy, V. N., Schikorski, T., Stevens, C. F., & Zhu, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00500-1 · Cited by 612
Regulation of transcription factors by neuronal activity
West, A. E., Griffith, E. C., & Greenberg, M. E. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn987 · Cited by 610
Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory
Adams, J. P., & Sweatt, J. D. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.145401 · Cited by 598
A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II
Chen, H.-J., Rojas-Soto, M., Oguni, A., & Kennedy, M. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)80471-7 · Cited by 590
Critical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
Quinlan, E. M., Philpot, B. D., Huganir, R. L., & Bear, M. F. (1999) · Nature Neuroscience · doi:10.1038/7263 · Cited by 579
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00687-1 · Cited by 567
Molecular determinants of NMDA receptor internalization
Roche, K. W., Standley, S., McCallum, J., Dune Ly, C., Ehlers, M. D., & Wenthold, R. J. (2001) · Nature Neuroscience · doi:10.1038/90498 · Cited by 550
Self-citation
Internalization of ionotropic glutamate receptors in response to mGluR activation
Snyder, E. M., Philpot, B. D., Huber, K. M., Dong, X., Fallon, J. R., & Bear, M. F. (2001) · Nature Neuroscience · doi:10.1038/nn746 · Cited by 539
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity
Hardingham, G. E., Arnold, F. J. L., & Bading, H. (2001) · Nature Neuroscience · doi:10.1038/85109 · Cited by 537
A developmental change in NMDA receptor-associated proteins at hippocampal synapses
Sans, N., Petralia, R. S., Wang, Y.-X., Blahos, J., Hell, J. W., & Wenthold, R. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01260.2000 · Cited by 537
A Physiological Basis for a Theory of Synapse Modification
Bear, M. F., Cooper, L. N., & Ebner, F. F. (1987) · Science · doi:10.1126/science.3037696 · Cited by 528
Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse
Hestrin, S. (1992) · Nature · doi:10.1038/357686a0 · Cited by 520
Subunit-Specific NMDA Receptor Trafficking to Synapses
Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515
Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses
Petralia, R. S., Esteban, J. A., Wang, Y. –., Partridge, J. G., Zhao, H. –., Wenthold, R. J., & Malinow, R. (1999) · Nature Neuroscience · doi:10.1038/4532 · Cited by 496
Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons
Rao, A., & Craig, A. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80962-9 · Cited by 492
Common Forms of Synaptic Plasticity in the Hippocampus and Neocortex in Vitro
Kirkwood, A., Dudek, S. M., Gold, J. T., Aizenman, C. D., & Bear, M. F. (1993) · Science · doi:10.1126/science.8502997 · Cited by 483
NMDA Receptor-Dependent Ocular Dominance Plasticity in Adult Visual Cortex
Sawtell, N. B., Frenkel, M. Y., Philpot, B. D., Nakazawa, K., Tonegawa, S., & Bear, M. F. (2003) · Neuron · doi:10.1016/s0896-6273(03)00323-4 · Cited by 482
Ca2+ Signaling Requirements for Long-Term Depression in the Hippocampus
Cummings, J., Mulkey, R. M., Nicoll, R. A., & Malenka, R. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80102-6 · Cited by 465
Alternatively spliced isoforms of the NMDARI receptor subunit
Zukin, R. S., & Bennett, M. V. L. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93920-s · Cited by 464
Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo
Sprengel, R., Suchanek, B., Amico, C., Brusa, R., Burnashev, N., Rozov, A. V., Hvalby, Ø., Jensen, V., Paulsen, O., Andersen, P. N., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80921-6 · Cited by 460
Mobile NMDA Receptors at Hippocampal Synapses
Tovar, K. R., & Westbrook, G. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00658-x · Cited by 448
Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex.
Philpot, B. D., Sekhar, A. K., Shouval, H., & Bear, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00187-8 · Cited by 440
The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1
Krapivinsky, G. B., Krapivinsky, L., Manasian, Y., Ivanov, A., Tyzio, R., Pellegrino, C., Ben‐Ari, Y., Clapham, D. E., & Medina, I. (2003) · Neuron · doi:10.1016/s0896-6273(03)00645-7 · Cited by 431
Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates
Lodish, H. F., Kong, N., Snider, M. D., & Strous, G. J. (1983) · Nature · doi:10.1038/304080a0 · Cited by 431
Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience
Kirkwood, A., Lee, H., & Bear, M. F. (1995) · Nature · doi:10.1038/375328a0 · Cited by 430
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F. A., Lounis, B., & Choquet, D. (2004) · Nature Neuroscience · doi:10.1038/nn1270 · Cited by 429
Glycine binding primes NMDA receptor internalization
Nong, Y., Huang, Y., Ju, W. H., Kalia, L. V., Ahmadian, G., Wang, Y. T., & Salter, M. W. (2003) · Nature · doi:10.1038/nature01497 · Cited by 427
Protein kinase C modulates NMDA receptor trafficking and gating
Lan, J.-Y., Skeberdis, V. A., Jover, T., Grooms, S. Y., Lin, Y., Araneda, R. C., Zheng, X., Bennett, M. V. L., & Zukin, R. S. (2001) · Nature Neuroscience · doi:10.1038/86028 · Cited by 421
Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
Erreger, K., Dravid, S. M., Banke, T. G., Wyllie, D. J. A., & Traynelis, S. F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080028 · Cited by 421
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., & Ehlers, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03063.2001 · Cited by 418
Self-citation
The Influence of Prior Synaptic Activity on the Induction of Long-Term Potentiation
Huang, Y.-Y., Colino, A., Selig, D. K., & Malenka, R. C. (1992) · Science · doi:10.1126/science.1346729 · Cited by 412
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
Liao, D., Zhang, X., O’Brien, R., Ehlers, M., & Huganir, R. L. (1999) · Nature Neuroscience · doi:10.1038/4540 · Cited by 396
Self-citation
Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines
Blanpied, T. A., Scott, D. B., & Ehlers, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00979-0 · Cited by 392
Self-citation
Bidirectional, experience-dependent regulation of N- methyl- d -aspartate receptor subunit composition in the rat visual cortex during postnatal development
Quinlan, E. M., Olstein, D. H., & Bear, M. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12876 · Cited by 382
Trafficking of NMDA Receptors
Wenthold, R. J., Prybylowski, K., Standley, S., Sans, N., & Petralia, R. S. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135803 · Cited by 374
Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons
Stocca, G., & Vicini, S. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.013bu.x · Cited by 365
LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1
Grosshans, D. R., Clayton, D. A., Coultrap, S. J., & Browning, M. D. (2001) · Nature Neuroscience · doi:10.1038/nn779 · Cited by 362
Metaplasticity: A new vista across the field of synaptic plasticity
Abraham, W. C., & Tate, W. P. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00018-x · Cited by 356
PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants
Standley, S., Roche, K. W., McCallum, J. D., Sans, N., & Wenthold, R. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00161-6 · Cited by 352
Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses
Watt, A. J., van Rossum, M. C. W., MacLeod, K. M., Nelson, S. B., & Turrigiano, G. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81202-7 · Cited by 350
Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase
Pak, D. T. S., & Sheng, M. (2003) · Science · doi:10.1126/science.1082475 · Cited by 305
NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity
Carroll, R. C., & Zukin, R. S. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02272-5 · Cited by 303
A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication
Hardingham, G. E., Arnold, F. J. L., & Bading, H. (2001) · Nature Neuroscience · doi:10.1038/88380 · Cited by 290
Continual remodeling of postsynaptic density and its regulation by synaptic activity
Okabe, S., Kim, H., Miwa, A., Kuriu, T., & Okado, H. (1999) · Nature Neuroscience · doi:10.1038/12175 · Cited by 257
A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux
Vissel, B., Krupp, J., Heinemann, S. F., & Westbrook, G. L. (2001) · Nature Neuroscience · doi:10.1038/88404 · Cited by 252
Turnover Analysis of Glutamate Receptors Identifies a Rapidly Degraded Pool of the N-Methyl-d-aspartate Receptor Subunit, NR1, in Cultured Cerebellar Granule Cells
Huh, K.-H., & Wenthold, R. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.151 · Cited by 248
Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal
van Zundert, B., Yoshii, A., & Constantine‐Paton, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.010 · Cited by 248
A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels
Xie, J., & Black, D. L. (2001) · Nature · doi:10.1038/35073593 · Cited by 248
Activity-Dependent mRNA Splicing Controls ER Export and Synaptic Delivery of NMDA Receptors
Mu, Y., Otsuka, T., Horton, A. C., Scott, D. B., & Ehlers, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00676-7 · Cited by 246
Self-citation
Subunit-Specific Regulation of NMDA Receptor Endocytosis
Lavezzari, G., McCallum, J. D., Dewey, C. M., & Roche, K. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1890-04.2004 · Cited by 244
Remodeling of Synaptic Membranes after Induction of Long-Term Potentiation
Toni, N., Buchs, P.-A., Nikonenko, I., Povilaitite, P., Parisi, L., & Muller, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06245.2001 · Cited by 244
The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity
Kim, J. H., Lee, H.-K., Takamiya, K., & Huganir, R. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01119.2003 · Cited by 240
Synaptic gain control and homeostasis
Burrone, J., & Murthy, V. N. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.09.007 · Cited by 236
Changes in voltage dependence of NMDA currents during development
Ben‐Ari, Y., Cherubini, E., & Krnjević, K. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90275-3 · Cited by 231
Different forms of LTD in the CA1 region of the hippocampus: role of age and stimulus protocol
Kemp, N. M., McQueen, J., Faulkes, S., & Bashir, Z. I. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00903.x · Cited by 213
Ubiquitin-Mediated Proteasome Activity Is Required for Agonist-Induced Endocytosis of GluRs
Patrick, G. N., Bingol, B., Weld, H. A., & Schuman, E. M. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.028 · Cited by 205
Evidence for Altered NMDA Receptor Function as a Basis for Metaplasticity in Visual Cortex
Philpot, B. D., Espinosa, J. S., & Bear, M. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05583.2003 · Cited by 187
Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors
Scott, D. B., Blanpied, T. A., & Ehlers, M. D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00250-8 · Cited by 186
Self-citation
Long-Term Depression at Thalamocortical Synapses in Developing Rat Somatosensory Cortex
Feldman, D. E., Nicoll, R. A., Malenka, R. C., & Isaac, J. T. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80544-9 · Cited by 186
Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction
Köhr, G., Jensen, V., Koester, H. J., Mihaljević, A. L., Utvik, J. K., Kvello, A., Ottersen, O. P., Seeburg, P. H., Sprengel, R., & Hvalby, Ø. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10791.2003 · Cited by 183
Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition
Lu, H., Gonzalez, E., & Crair, M. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00501-3 · Cited by 180
A proportional but slower NMDA potentiation follows AMPA potentiation in LTP
Watt, A. J., Sjöström, P. J., Häusser, M., Nelson, S. B., & Turrigiano, G. G. (2004) · Nature Neuroscience · doi:10.1038/nn1220 · Cited by 178
Cycling of NMDA Receptors during Trafficking in Neurons before Synapse Formation
Washbourne, P., Liu, X.-B., Jones, E. G., & McAllister, A. K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2555-04.2004 · Cited by 167
Differential regulation of synaptic and extra-synaptic NMDA receptors
Li, B., Chen, N., Luo, T., Otsu, Y., Murphy, T. H., & Raymond, L. A. (2002) · Nature Neuroscience · doi:10.1038/nn912 · Cited by 162
A Molecular Mechanism for Stabilization of Learning-Induced Synaptic Modifications
Quinlan, E. M., Lebel, D., Brosh, I., & Barkai, E. (2004) · Neuron · doi:10.1016/s0896-6273(03)00874-2 · Cited by 161
Relationship between Availability of NMDA Receptor Subunits and Their Expression at the Synapse
Prybylowski, K., Fu, Z., Losi, G., Hawkins, L. M., Luo, J., Chang, K., Wenthold, R. J., & Vicini, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08902.2002 · Cited by 154
State-Dependent Heterogeneity in Synaptic Depression between Pyramidal Cell Pairs
Montgomery, J. M., & Madison, D. V. (2002) · Neuron · doi:10.1016/s0896-6273(02)00606-2 · Cited by 152
Rapid Synaptic Remodeling by Protein Kinase C: Reciprocal Translocation of NMDA Receptors and Calcium/Calmodulin-Dependent Kinase II
Fong, D. K., Rao, A., Crump, F. T., & Craig, A. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02153.2002 · Cited by 150
Differential Surface Expression and Phosphorylation of the N-Methyl-D-aspartate Receptor Subunits NR1 and NR2 in Cultured Hippocampal Neurons
Hall, R. A., & Soderling, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4135 · Cited by 143
A Morphological Correlate of Synaptic Scaling in Visual Cortex
Wallace, W., & Bear, M. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1110-04.2004 · Cited by 141
cAMP-Dependent Protein Kinase Mediates Activity-Regulated Synaptic Targeting of NMDA Receptors
Crump, F. T., Dillman, K. S., & Craig, A. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05079.2001 · Cited by 140
Role of the Carboxy-Terminal Region of the GluRε2 Subunit in Synaptic Localization of the NMDA Receptor Channel
Mori, H., Manabe, T., Watanabe, M., Satoh, Y., Suzuki, N., Toki, S., Nakamura, K., Yagi, T., Kushiya, E., Takahashi, T., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80567-x · Cited by 136
Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals
Scott, D. B., Michailidis, I. E., Mu, Y., Logothetis, D. E., & Ehlers, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0780-04.2004 · Cited by 130
Self-citation
Postsynaptic Depolarization Scales Quantal Amplitude in Cortical Pyramidal Neurons
Leslie, K. R., Nelson, S. B., & Turrigiano, G. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-j0005.2001 · Cited by 128
Priming-Induced Shift in Synaptic Plasticity in the Rat Hippocampus
Wang, H., & Wagner, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.2024 · Cited by 126
Decline of the Critical Period of Visual Plasticity Is Concurrent with the Reduction of NR2B Subunit of the Synaptic NMDA Receptor in Layer 4
Erisir, A., & Harris, J. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05208.2003 · Cited by 111
Activity‐dependent Regulation of N‐Methyl‐ d ‐aspartate Receptor Subunit Expression in Rat Cerebellar Granule Cells
Audinat, É., Lambolez, B., Rossier, J., & Crépel, F. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00572.x · Cited by 107
Developmental loss of miniature N -methyl- d -aspartate receptor currents in NR2A knockout mice
Townsend, M., Yoshii, A., Mishina, M., & Constantine‐Paton, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0335786100 · Cited by 107
Activity-Dependent Regulation of NMDAR1 Immunoreactivity in the Developing Visual Cortex
Catalano, S. M., Chang, C. K., & Shatz, C. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08376.1997 · Cited by 98
Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel
Mori, H., Yamakura, T., Hisashi, M., & Mishina, M. (1993) · Neuroreport · doi:10.1097/00001756-199305000-00014 · Cited by 97
Genetic and epigenetic regulation of NMDA receptor expression in the rat visual cortex
Nase, G., Weishaupt, J. H., Stern, P., Singer, W., & Monyer, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00859.x · Cited by 92
Export from the Endoplasmic Reticulum of Assembled N-Methyl-D-aspartic Acid Receptors Is Controlled by a Motif in the C Terminus of the NR2 Subunit
Hawkins, L. M., Prybylowski, K., Chang, K., Moussan, C., Stephenson, F. A., & Wenthold, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402599200 · Cited by 86
NMDA receptors are movin? in
Nong, Y., Huang, Y., & Salter, M. W. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.001 · Cited by 79
Reduced Mg2+ block of N-methyl-D-aspartate receptor-mediated synaptic potentials in developing visual cortex.
Kato, N., & Yoshimura, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7114 · Cited by 79
Critical period control in sensory cortex
Fox, K. D., & Zahs, K. R. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90040-x · Cited by 67
Metaplasticity: the plasticity of synaptic plasticity
Philpot, B. D., Bear, M. F., & Abraham, W. C. (1999) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198524243.003.0005 · Cited by 6

Sorted by citations

Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139
Metaplasticity: tuning synapses and networks for plasticity
Abraham, W. C. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2356 · Cited by 1,166
Dopamine-mediated regulation of corticostriatal synaptic plasticity
Calabresi, P., Picconi, B., Tozzi, A., & Di Filippo, M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.001 · Cited by 865
Synaptic plasticity and dysconnection in schizophrenia
Stephan, K. E., Baldeweg, T., & Friston, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.005 · Cited by 841

See all 357

Authors: Pérez-Otaño, I., & Ehlers, M. D.
Affiliations: Duke Medical Center (US)
Corresponding author: Ehlers, Michael D.
ORCID: Ehlers, Michael D.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2005-05
Volume: 28
Issue: 5
Pages: 229-238
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2005.03.004
OpenAlex: W2020939800
Cited by: 356
References: 116
Citations by year: 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 11 · 2019: 16 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 25 · 2012: 22
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health (R01MH064748, MH 64748)
National Institute of Neurological Disorders and Stroke (NS 39402, R01NS039402, NS 32742)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: homeostatic plasticity, NMDA receptor trafficking, synaptic scaling, metaplasticity, Hebbian plasticity, long-term potentiation, long-term depression, AMPA receptor trafficking, glutamatergic synapses, activity-dependent synaptic plasticity
MeSH terms: Animals, Homeostasis, Humans, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Protein Transport

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Homeostatic plasticity and NMDA receptor trafficking

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks