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Homeostatic plasticity and NMDA receptor trafficking

Pérez-Otaño, Isabel, Ehlers, Michael D.·2005·Trends in Neurosciences

DOI 10.1016/j.tins.2005.03.004

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Abstract

Learning, memory and brain development are associated with long-lasting modifications of synapses that are guided by specific patterns of neuronal activity. Such modifications include classical Hebbian plasticities (such as long-term potentiation and long-term depression), which are rapid and synapse-specific, and others, such as synaptic scaling and metaplasticity, that work over longer timescales and are crucial for maintaining and orchestrating neuronal network function. The cellular mechanisms underlying Hebbian plasticity have been well studied and involve rapid changes in the trafficking of highly mobile AMPA receptors. An emerging concept is that activity-dependent alterations in NMDA receptor trafficking contribute to homeostatic plasticity at central glutamatergic synapses.

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“org causing impairment of the ubiquitin-proteasome system,(9)which also controls the fate of NMDARs undergoing endocytic vesicular trafficking.(50) ApoE-promoted buildup of Ab oligomers along the endosomal/lysosomal pathway may therefore affect intracellular trafficking and sorting of synaptic proteins and may indicat…”
Background
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Authors: Pérez-Otaño, I., & Ehlers, M. D.
Affiliations: Duke Medical Center (US)
Corresponding author: Ehlers, Michael D.
ORCID: Ehlers, Michael D.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2005-05
Volume: 28
Issue: 5
Pages: 229-238
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2005.03.004
OpenAlex: W2020939800
Cited by: 356
References: 116
Citations by year: 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 11 · 2019: 16 · 2018: 7 · 2017: 12 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 25 · 2012: 22
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute of Mental Health (R01MH064748, MH 64748)
National Institute of Neurological Disorders and Stroke (NS 39402, R01NS039402, NS 32742)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: homeostatic plasticity, NMDA receptor trafficking, synaptic scaling, metaplasticity, Hebbian plasticity, long-term potentiation, long-term depression, AMPA receptor trafficking, glutamatergic synapses, activity-dependent synaptic plasticity
MeSH terms: Animals, Homeostasis, Humans, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Protein Transport

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