Cited by 397Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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Microglial senescence: does the brain's immune system have an expiration date?

Streit, Wolfgang J.·2006·Trends in Neurosciences

DOI 10.1016/j.tins.2006.07.001

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Abstract

Microglia are seen as the sentries in the CNS who provide a first line of defense whenever there is injury or disease. Microglia and related perivascular macrophages perform various functions, ranging from immunological surveillance to neuroprotection. Recent work in the aged human brain has provided morphological evidence of structural deterioration of microglia, and work in rodents suggests that microglia are subject to replicative senescence (loss of mitotic ability after repeated rounds of replication). Together these observations raise the possibility that old age, and perhaps other factors (genetic and epigenetic) adversely affect viability and self-renewal capacity of microglia, resulting in the generation of senescent and/or dysfunctional cells. Such attrition of the brain's immune system could contribute to the development of neurodegenerative disease by diminishing glial neuroprotection.

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Authors: Streit, W. J.
Affiliations: University of Florida Health (US)
Corresponding author: Streit, Wolfgang J.
ORCID: Streit, Wolfgang J.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2006-09
Volume: 29
Issue: 9
Pages: 506-510
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2006.07.001
OpenAlex: W1981310043
Cited by: 397
References: 42
Citations by year: 2026: 4 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 18 · 2020: 22 · 2019: 21 · 2018: 18 · 2017: 18 · 2016: 26 · 2015: 22 · 2014: 23 · 2013: 20 · 2012: 40
FWCI: 2.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: microglial senescence, replicative senescence, microglia, perivascular macrophages, brain aging, neuroinflammation, neuroprotection, neurodegenerative diseases, immunosenescence
MeSH terms: Aging, Animals, Brain, Humans, Cellular Senescence, Microglia

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Microglial senescence: does the brain's immune system have an expiration date?

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