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Lipoprotein receptors in Alzheimer's disease

Andersen, Olav M., Willnow, Thomas E.·2006·Trends in Neurosciences
DOI 10.1016/j.tins.2006.09.002
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Abstract

Lipoprotein receptors have important roles in pathological processes that lead to Alzheimer's disease (AD). Previously, they were believed to act mainly by modulating the neuronal metabolism of cholesterol and apolipoprotein E, major risk factors for spontaneous AD. However, recent findings point towards an unexpected new function for lipoprotein receptors in regulation of intracellular transport and processing of the amyloid precursor protein (APP) to give amyloid-beta peptide, the principal component of senile plaques. Here, we will discuss how lipoprotein receptors might modulate distinct steps in neuronal trafficking of APP, and how an intricate balance between opposing receptor activities might be a crucial determinant of APP processing, and of onset and progression of neurodegeneration.

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  • LRP1 is highly expressed in neurons at the post-synaptic density.

    “Native LRP1 is highly expressed in neurons at the post-synaptic density17,18”

    From LRP1 is a master regulator of tau uptake and spread (2020) · cites this paper as [17]

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Metadata

Authors
Andersen, O. M., & Willnow, T. E.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2006-12
Volume
29
Issue
12
Pages
687-694
ISSN
0166-2236
DOI
10.1016/j.tins.2006.09.002
Cited by
41
References
9
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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