Cited by 224Psychosomatic Disorders and Their TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

Anterior insular cortex mediates bodily sensibility and social anxiety

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Terasawa, Yuri, Shibata, Midori, Moriguchi, Yoshiya, Umeda, Satoshi·2013·Social Cognitive and Affective Neuroscience

Abstract

Studies in psychiatry and cognitive neuroscience have reported an important relationship between individual interoceptive accuracy and anxiety level. This indicates that greater attention to one's bodily state may contribute to the development of intense negative emotions and anxiety disorders. We hypothesized that reactivity in the anterior insular cortex underlies the intensity of interoceptive awareness and anxiety. To elucidate this triadic mechanism, we conducted functional magnetic resonance imaging (fMRI) and mediation analyses to examine the relationship between emotional disposition and activation in the anterior insular cortex while participants evaluated their own emotional and bodily states. Our results indicated that right anterior insular activation was positively correlated with individual levels of social anxiety and neuroticism and negatively correlated with agreeableness and extraversion. The results of the mediation analyses revealed that activity in the right anterior insula mediated the activity of neural correlates of interoceptive sensibility and social fear. Our findings suggest that attention to interoceptive sensation affects personality traits through how we feel emotion subjectively in various situations.

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Crossref · 10.1093/scan/nss108

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  • Studies indicate that socially anxious individuals pay more attention to their internal bodily sensations, resulting in enhanced interoceptive sensibility and accuracy.

    “Studies indicate that socially anxious individuals pay more attention to their internal bodily sensations, resulting in enhanced interoceptive sensibility (Terasawa et al. 2013) and accuracy (Stevens et al. 2011; see Garfinkel et al. 2015, for the distinction between facets of interoception).”
  • Activation of the anterior insula is associated with anxiety level.

    “Other research has shown that activation of the anterior insula is associated with anxiety level (Terasawa et al., 2013; Mallorquí-Bagué et al., 2014).”

    From Mindfulness, Interoception, and the Body: A Contemporary Perspective (2019) · cites this paper as Terasawa et al., 2013

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Authors
Terasawa, Y., Shibata, M., Moriguchi, Y., & Umeda, S.
Affiliations
  • Japan Society for the Promotion of Science (JP)
  • Keio University (JP)
Venue
Social Cognitive and Affective Neuroscience
Published
2012-09-13
Volume
8
Issue
3
Pages
259-266
ISSN
  • 1749-5016 (ISSN-L)
  • 1749-5024
OpenAlex
W2097538354
Cited by
224
References
68
Citations by year
2026: 8 · 2025: 19 · 2024: 35 · 2023: 17 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 16 · 2018: 20 · 2017: 14 · 2016: 9 · 2015: 23 · 2014: 16 · 2013: 6
FWCI
10.28
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Keio University
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science (23330201, 23700318, 24120518, 21330168, 24330210, 23390192)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
anterior insula, interoceptive awareness, interoceptive accuracy, social anxiety, social fear, personality traits, neuroticism, agreeableness, extraversion, affective dispositions, mediation analysis
MeSH terms
Adult, Analysis of Variance, Anxiety, Awareness, Brain Mapping, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Surveys and Questionnaires, Reaction Time, Sensation, Social Behavior, Young Adult

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