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β-Secretase: its biology as a therapeutic target in diseases

Wang, Haibo, Li, Rena, Shen, Yong·2013·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2013.01.008PMC PMC3691103
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  • BACE1 knockout mice models exhibit reduced weight gain, increased energy expenditure, and enhanced leptin signaling.

    “The phenotype of the BACE1 knockout mice models, including reduced weight gain, increased energy expenditure, and enhanced leptin signaling, proposes a physiological role of BACE1 in regulating energy metabolism and homeostasis.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [6]

  • The BACE1 protein is acetylated at seven different lysine residues mediated by CoA:lysine acetyltransferase 1 and 2, and ubiquitinated at K501 which causes translocation to the lysosomes for degradation.

    “The BACE1 protein is also acetylated at seven different lysine residues mediated by CoA:lysine acetyltransferase 1 and 2 (ATase 1 and ATase 2), and ubiquitinated at K501 which causes translocation to the lysosomes for degradation.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [6]

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Research works printed but not linked: 104

  1. Hussain, 1999, Identification of a novel aspartic protease (Asp 2) as beta-secretase, Mol. Cell. Neurosci., 14, 419, 10.1006/mcne.1999.0811 · DOI · Paper page
  2. Sinha, 1999, Purification and cloning of amyloid precursor protein beta-secretase from human brain, Nature, 402, 537, 10.1038/990114 · DOI · Paper page
  3. Vassar, 1999, Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science, 286, 735, 10.1126/science.286.5440.735 · DOI · Paper page
  4. Yan, 1999, Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity, Nature, 402, 533, 10.1038/990107 · DOI · Paper page
  5. Lin, 2000, Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein, Proc. Natl. Acad. Sci. U.S.A., 97, 1456, 10.1073/pnas.97.4.1456 · DOI
  6. Yan, 2001, BACE2 functions as an alternative alpha-secretase in cells, J. Biol. Chem., 276, 34019, 10.1074/jbc.M105583200 · DOI
  7. Casas, 2010, BACE2 plays a role in the insulin receptor trafficking in pancreatic β-cells, Am. J. Physiol. Endocrinol. Metab., 299, E1087, 10.1152/ajpendo.00420.2010 · DOI
  8. Holler, 2012, BACE2 expression increases in human neurodegenerative disease, Am. J. Pathol., 180, 337, 10.1016/j.ajpath.2011.09.034 · DOI
  9. Bennett, 2000, Expression analysis of BACE2 in brain and peripheral tissues, J. Biol. Chem., 275, 20647, 10.1074/jbc.M002688200 · DOI · Paper page
  10. Huse, 2000, Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease β-secretase, J. Biol. Chem., 275, 33729, 10.1074/jbc.M004175200 · DOI · Paper page
  11. Haniu, 2000, Characterization of Alzheimer's β-secretase protein BACE. A pepsin family member with unusual properties, J. Biol. Chem., 275, 21099, 10.1074/jbc.M002095200 · DOI
  12. Shiba, 2004, Insights into the phosphoregulation of β-secretase sorting signal by the VHS domain of GGA1, Traffic, 5, 437, 10.1111/j.1600-0854.2004.00188.x · DOI · Paper page
  13. Kang, 2010, Ubiquitin regulates GGA3-mediated degradation of BACE1, J. Biol. Chem., 285, 24108, 10.1074/jbc.M109.092742 · DOI · Paper page
  14. Costantini, 2007, A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1, Biochem. J., 407, 383, 10.1042/BJ20070040 · DOI · Paper page
  15. Shi, 2001, The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain, J. Biol. Chem., 276, 10366, 10.1074/jbc.M009200200 · DOI
  16. Benjannet, 2001, Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production, J. Biol. Chem., 276, 10879, 10.1074/jbc.M009899200 · DOI · Paper page
  17. Capell, 2000, Maturation and pro-peptide cleavage of beta-secretase, J. Biol. Chem., 275, 30849, 10.1074/jbc.M003202200 · DOI · Paper page
  18. Jin, 2010, Evidence for dimeric BACE-mediated APP processing, Biochem. Biophys. Res. Commun., 393, 21, 10.1016/j.bbrc.2010.01.064 · DOI
  19. Westmeyer, 2004, Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme, J. Biol. Chem., 279, 53205, 10.1074/jbc.M410378200 · DOI
  20. Yan, 2001, The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta-amyloid precursor protein (APP) substrate, J. Biol. Chem., 276, 36788, 10.1074/jbc.M104350200 · DOI
  21. Hong, 2000, Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor, Science, 290, 150, 10.1126/science.290.5489.150 · DOI
  22. Shimizu, 2008, Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production, Mol. Cell. Biol., 28, 3663, 10.1128/MCB.02185-07 · DOI · Paper page
  23. Spronk, 2011, The role of tyrosine 71 in modulating the flap conformations of BACE1, Proteins, 79, 2247, 10.1002/prot.23050 · DOI
  24. Marquer, 2011, Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis, FASEB J., 25, 1295, 10.1096/fj.10-168633 · DOI
  25. Bolkan, 2012, β-Secretase cleavage of the fly amyloid precursor protein is required for glial survival, J. Neurosci., 32, 16181, 10.1523/JNEUROSCI.0228-12.2012 · DOI
  26. Li, 2010, Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP, Proc. Natl. Acad. Sci. U.S.A., 107, 17362, 10.1073/pnas.1012568107 · DOI · Paper page
  27. Chasseigneaux, 2011, Secreted amyloid precursor protein beta and secreted amyloid precursor protein alpha induce axon outgrowth in vitro through Egr1 signaling pathway, PLoS ONE, 6, e16301, 10.1371/journal.pone.0016301 · DOI
  28. Baratchi, 2011, Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells, Hippocampus, 22, 1517, 10.1002/hipo.20988 · DOI
  29. Furukawa, 1996, Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein, Nature, 379, 74, 10.1038/379074a0 · DOI
  30. Freude, 2011, Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells, J. Biol. Chem., 86, 24264, 10.1074/jbc.M111.227421 · DOI
  31. Nikolaev, 2009, APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, Nature, 457, 981, 10.1038/nature07767 · DOI · Paper page
  32. Belyaev, 2010, The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a β-secretase-dependent pathway, J. Biol. Chem., 285, 41443, 10.1074/jbc.M110.141390 · DOI
  33. Lefort, 2012, Cross-linking of cell surface amyloid precursor protein leads to increased beta-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease, J. Neurosci., 32, 10674, 10.1523/JNEUROSCI.6473-11.2012 · DOI
  34. Ma, 2007, Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity, Proc. Natl. Acad. Sci. U.S.A., 104, 8167, 10.1073/pnas.0609521104 · DOI
  35. Kimura, 2010, Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice, J. Neurochem., 113, 248, 10.1111/j.1471-4159.2010.06608.x · DOI
  36. Ishida, 1997, Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices, Neuroreport, 8, 2133, 10.1097/00001756-199707070-00009 · DOI
  37. Furukawa, 1996, Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain, J. Neurochem., 67, 1882, 10.1046/j.1471-4159.1996.67051882.x · DOI
  38. Hu, 2008, Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves, FASEB J., 22, 2970, 10.1096/fj.08-106666 · DOI · Paper page
  39. Hu, 2006, Bace1 modulates myelination in the central and peripheral nervous system, Nat. Neurosci., 9, 1520, 10.1038/nn1797 · DOI · Paper page
  40. Luo, 2011, Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination, J. Biol. Chem., 286, 23967, 10.1074/jbc.M111.251538 · DOI
  41. Brackenbury, 2010, Functional reciprocity between Na+ channel Nav1.6 and β1 subunits in the coordinated regulation of excitability and neurite outgrowth, Proc. Natl. Acad. Sci. U.S.A., 107, 2283, 10.1073/pnas.0909434107 · DOI
  42. Gersbacher, 2010, Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit, Mol. Neurodegener., 5, 61, 10.1186/1750-1326-5-61 · DOI · Paper page
  43. Kim, 2011, Reduced sodium channel Na(v)1.1 levels in BACE1-null mice, J. Biol. Chem., 286, 8106, 10.1074/jbc.M110.134692 · DOI
  44. Kim, 2007, BACE1 regulates voltage-gated sodium channels and neuronal activity, Nat. Cell Biol., 9, 755, 10.1038/ncb1602 · DOI
  45. Huth, 2011, β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current, Pflugers Arch., 461, 355, 10.1007/s00424-010-0913-2 · DOI
  46. Huth, 2009, Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function, Neurobiol. Dis., 33, 282, 10.1016/j.nbd.2008.10.015 · DOI
  47. Lichtenthaler, 2003, The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1, J. Biol. Chem., 278, 48713, 10.1074/jbc.M303861200 · DOI · Paper page
  48. Kitazume, 2004, Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate, Glycoconj. J., 20, 59, 10.1023/B:GLYC.0000016743.25495.45 · DOI
  49. Jones, 2010, Role for hepatic and circulatory ST6Gal-1 sialyltransferase in regulating myelopoiesis, J. Biol. Chem., 285, 25009, 10.1074/jbc.M110.104406 · DOI
  50. Woodard-Grice, 2008, Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of α4β1 integrins, J. Biol. Chem., 283, 26364, 10.1074/jbc.M800836200 · DOI
  51. Kihara, 2010, Aβ-induced BACE-1 cleaves N-terminal sequence of mPGES-2, Biochem. Biophys. Res. Commun., 393, 728, 10.1016/j.bbrc.2010.02.069 · DOI
  52. Kuhn, 2007, Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase, J. Biol. Chem., 282, 11982, 10.1074/jbc.M700356200 · DOI · Paper page
  53. Hoffmeister, 2009, BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro, JOP, 10, 501
  54. Zhou, 2012, The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 in vivo, J. Neurochem., 287, 25927
  55. Hemming, 2009, Identification of beta-secretase (BACE1) substrates using quantitative proteomics, PLoS ONE, 4, e8477, 10.1371/journal.pone.0008477 · DOI
  56. Tesco, 2007, Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity, Neuron, 54, 721, 10.1016/j.neuron.2007.05.012 · DOI · Paper page
  57. Kametaka, 2003, Identification of phospholipid scramblase 1 as a novel interacting molecule with beta-secretase (beta-site amyloid precursor protein (APP) cleaving enzyme (BACE)), J. Biol. Chem., 278, 15239, 10.1074/jbc.M208611200 · DOI · Paper page
  58. Marks, 2010, BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis, Neurochem. Res., 35, 181, 10.1007/s11064-009-0054-1 · DOI
  59. Spoelgen, 2006, Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme, J. Neurosci., 26, 418, 10.1523/JNEUROSCI.3882-05.2006 · DOI · Paper page
  60. Finan, 2011, BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin, J. Biol. Chem., 286, 12602, 10.1074/jbc.M110.170217 · DOI · Paper page
  61. He, 2004, Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation, Nat. Med., 10, 959, 10.1038/nm1088 · DOI
  62. Hu, 2007, Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities, EMBO J., 26, 2755, 10.1038/sj.emboj.7601707 · DOI
  63. Xie, 2005, PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein, J. Biol. Chem., 280, 13824, 10.1074/jbc.M411933200 · DOI
  64. Supnet, 2011, Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis, Cell Calcium, 50, 303, 10.1016/j.ceca.2011.05.013 · DOI
  65. Kuzuya, 2007, Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1), J. Neurosci. Res., 85, 153, 10.1002/jnr.21104 · DOI
  66. Huang, 2004, Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein, J. Biol. Chem., 279, 37886, 10.1074/jbc.M402130200 · DOI
  67. Griffiths, 2011, Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein, J. Biol. Chem., 286, 33489, 10.1074/jbc.M111.278556 · DOI
  68. Wickham, 2005, Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin, J. Neurochem., 92, 93, 10.1111/j.1471-4159.2004.02840.x · DOI
  69. Fischer, 2012, Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy, Exp. Neurol., 233, 163, 10.1016/j.expneurol.2011.09.020 · DOI
  70. Ermolieff, 2000, Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates, Biochemistry, 39, 16263, 10.1021/bi005122i · DOI
  71. Charlwood, 2001, Characterization of the glycosylation profiles of Alzheimer's beta-secretase protein Asp-2 expressed in a variety of cell lines, J. Biol. Chem., 276, 16739, 10.1074/jbc.M009361200 · DOI
  72. Harrison, 2003, BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes, Mol. Cell. Neurosci., 24, 646, 10.1016/S1044-7431(03)00227-6 · DOI · Paper page
  73. Luo, 2001, Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation, Nat. Neurosci., 4, 231, 10.1038/85059 · DOI · Paper page
  74. Ohno, 2006, Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1, Eur. J. Neurosci., 23, 251, 10.1111/j.1460-9568.2005.04551.x · DOI · Paper page
  75. Zhao, 2007, Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis, J. Neurosci., 27, 3639, 10.1523/JNEUROSCI.4396-06.2007 · DOI · Paper page
  76. Mowrer, 2008, Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production, J. Biol. Chem., 283, 18694, 10.1074/jbc.M801322200 · DOI · Paper page
  77. Wang, 2012, Lys203 and Lys382 are essential for the proteasomal degradation of BACE1, Curr. Alzheimer Res., 9, 606, 10.2174/156720512800618026 · DOI
  78. Zhang, 2012, Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1, J. Neurochem., 120, 1129, 10.1111/j.1471-4159.2011.07644.x · DOI
  79. O’Connor, 2008, Phosphorylation of the translation initiation factor eIF2α increases BACE1 levels and promotes amyloidogenesis, Neuron, 60, 988, 10.1016/j.neuron.2008.10.047 · DOI
  80. Hebert, 2009, MicroRNA regulation of Alzheimer's amyloid precursor protein expression, Neurobiol. Dis., 33, 422, 10.1016/j.nbd.2008.11.009 · DOI · Paper page
  81. Sambamurti, 2004, Gene structure and organization of the human beta-secretase (BACE) promoter, FASEB J., 18, 1034, 10.1096/fj.03-1378fje · DOI
  82. Sastre, 2006, Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARγ, Proc. Natl. Acad. Sci. U.S.A., 103, 443, 10.1073/pnas.0503839103 · DOI · Paper page
  83. Sadleir, 2012, Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease, J. Biol. Chem., 287, 7224, 10.1074/jbc.M111.333914 · DOI
  84. Jo, 2010, Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease, Neurobiol. Aging, 31, 917, 10.1016/j.neurobiolaging.2008.07.003 · DOI
  85. Takasugi, 2011, BACE1 activity is modulated by cell-associated sphingosine-1-phosphate, J. Neurosci., 31, 6850, 10.1523/JNEUROSCI.6467-10.2011 · DOI · Paper page
  86. Kalvodova, 2005, Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro, J. Biol. Chem., 280, 36815, 10.1074/jbc.M504484200 · DOI
  87. Cole, 2005, Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism, J. Biol. Chem., 280, 18755, 10.1074/jbc.M413895200 · DOI
  88. Parsons, 2006, Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms, Biochem. J., 399, 205, 10.1042/BJ20060655 · DOI
  89. McAllister, 2010, Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment, J. Neurosci., 30, 7326, 10.1523/JNEUROSCI.1180-10.2010 · DOI
  90. Yue, 2005, Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model, Proc. Natl. Acad. Sci. U.S.A., 102, 19198, 10.1073/pnas.0505203102 · DOI
  91. Green, 2006, Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease, J. Neurosci., 26, 9047, 10.1523/JNEUROSCI.2797-06.2006 · DOI · Paper page
  92. Chen, 2009, Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription, Proc. Natl. Acad. Sci. U.S.A., 106, 3907, 10.1073/pnas.0807991106 · DOI · Paper page
  93. Zhang, 2009, Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development, Eur. J. Neurosci., 30, 2271, 10.1111/j.1460-9568.2009.07017.x · DOI
  94. Lee, 2011, Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-beta generation and inflammatory reactions via inhibition of NF-kappaB and STAT3 activation in cultured astrocytes and microglial BV-2 cells, J. Neuroinflammation, 8, 132, 10.1186/1742-2094-8-132 · DOI
  95. Guglielmotto, 2009, The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α, J. Neurochem., 108, 1045, 10.1111/j.1471-4159.2008.05858.x · DOI
  96. Kwak, 2011, Differential regulation of BACE1 expression by oxidative and nitrosative signals, Mol. Neurodegener., 6, 17, 10.1186/1750-1326-6-17 · DOI
  97. Hitt, 2010, BACE1−/− mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization, Mol. Neurodegener., 5, 31, 10.1186/1750-1326-5-31 · DOI · Paper page
  98. Mancini, 2011, Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors, Anal. Bioanal. Chem., 400, 1979, 10.1007/s00216-011-4963-x · DOI
  99. Chang, 2011, β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice, FASEB J., 25, 775, 10.1096/fj.10-167213 · DOI
  100. May, 2011, Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor, J. Neurosci., 31, 16507, 10.1523/JNEUROSCI.3647-11.2011 · DOI · Paper page
  101. He, 2013, Long-term treatment of thalidomide ameliorates Alzheimer-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease, PLoS ONE, 8, e55091, 10.1371/journal.pone.0055091 · DOI
  102. Sabbagh, 2010, Rationale and strategy for thalidomide as a BACE1 inhibitor for a Phase II randomized clinical trial in mild to moderate Alzheimer's disease, J. Alzheimers Dis., 19, 621
  103. Kennelly, 2011, Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study, Int. J. Geriatr. Psychiatry, 6, 1038, 10.1002/gps.2638 · DOI
  104. He, P. et al. Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces abnormal processing of amyloid precursor protein in a mouse model of Alzheimer's disease. PLoS ONE, http://dx.doi.org/10.1371/journal.pone.0058181 · DOI

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Metadata

Authors
Wang, H., Li, R., & Shen, Y.
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2013-04
Volume
34
Issue
4
Pages
215-225
ISSN
0165-6147
DOI
10.1016/j.tips.2013.01.008
PMC
PMC3691103
Cited by
69
References
14
Language
en

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