Adipokines in health and disease

Positional cloning of the mouse obese gene and its human homologue

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Adipose Tissue as an Endocrine Organ

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Identification and Importance of Brown Adipose Tissue in Adult Humans

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Cold-Activated Brown Adipose Tissue in Healthy Men

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

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Functional Brown Adipose Tissue in Healthy Adults

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Mechanisms linking obesity with cardiovascular disease

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AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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FGF-21 as a novel metabolic regulator

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cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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Pharmacology, physiology, and mechanisms of incretin hormone action.

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

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Relationship between Adipocyte Size and Adipokine Expression and Secretion

Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1055 · Cited by 1,288

Adiponectin and protection against type 2 diabetes mellitus

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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

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Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity

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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

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Insulin-sensitive obesity

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TNF‐α and adipocyte biology

Cawthorn, W. P., & Sethi, J. K. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.051 · Cited by 833

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757

Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity

Hida, K., Wada, J., Eguchi, J., Zhang, H., Baba, M., Seida, A., Hashimoto, I., Okada, T., Yasuhara, A., Nakatsuka, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504703102 · Cited by 725

Adiponectin: mechanistic insights and clinical implications

Turer, A. T., & Scherer, P. E. (2012) · Diabetologia · doi:10.1007/s00125-012-2598-x · Cited by 650

Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

Mulvihill, E. E., & Drucker, D. J. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1035 · Cited by 641

Adipose tissue as a source of hormones

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Leptin in Human Physiology and Pathophysiology

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Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

Lamers, D., Famulla, S., Wronkowitz, N., Hartwig, S., Lehr, S., Ouwens, D. M., Eckardt, K., Kaufman, J., Rydén, M., Müller, S., et al. (2011) · Diabetes · doi:10.2337/db10-1707 · Cited by 583

Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

Dray, C., Knauf, C., Daviaud, D., Waget, A., Boucher, J., Buléon, M., Cani, P. D., Attané, C., Guigné, C., Carpéné, C., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.003 · Cited by 522

Adipocyte dysfunction, inflammation and metabolic syndrome

Klöting, N., & Blüher, M. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9301-0 · Cited by 487

Regulation of adipocyte lipolysis

Frühbeck, G., Méndez-Giménez, L., Fernández‐Formoso, J. A., Fernández, S., & Rodrı́guez, A. (2014) · Nutrition Research Reviews · doi:10.1017/s095442241400002x · Cited by 447

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

Roth, J. D., Roland, B. L., Cole, R. L., Trevaskis, J. L., Weyer, C., Koda, J. E., Anderson, C. M., Parkes, D. G., & Baron, A. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706473105 · Cited by 436

Adipose tissue dysfunction contributes to obesity related metabolic diseases

Blüher, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.02.005 · Cited by 430

Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420

Serum Vaspin Concentrations in Human Obesity and Type 2 Diabetes

Youn, B., Klöting, N., Kratzsch, J., Lee, N., Park, J. W., Song, E.-S., Ruschke, K., Oberbach, A., Faßhauer, M., Stümvoll, M., et al. (2007) · Diabetes · doi:10.2337/db07-1045 · Cited by 419

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

Blüher, M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.016 · Cited by 415

Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass

Klöting, N., Graham, T. E., Berndt, J., Kralisch, S., Kovacs, P. L., Wason, C. J., Faßhauer, M., Schön, M. R., Stümvoll, M., Blüher, M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.002 · Cited by 405

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

Lo, J. C., Ljubicic, S., Leibiger, B., Kern, M., Leibiger, I. B., Moede, T., Kelly, M. E., Bhowmick, D. C., Murano, I., Cohen, P., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.005 · Cited by 390

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

Schulz, T. J., Huang, P. C., Huang, T. L., Xue, R., McDougall, L. E., Townsend, K. L., Cypess, A. M., Mishina, Y. M., Gussoni, E., & Tseng, Y. (2013) · Nature · doi:10.1038/nature11943 · Cited by 389

Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

Lehr, S., Hartwig, S., & Sell, H. (2011) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201100052 · Cited by 376

Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy

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Severely Impaired Adipsin Expression in Genetic and Acquired Obesity

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Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload

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Incretin-Based Therapies for Type 2 Diabetes Mellitus: Properties, Functions, and Clinical Implications

Nauck, M. A. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.11.002 · Cited by 298

Apelin, diabetes, and obesity

Castan‐Laurell, I., Dray, C., Attané, C., Duparc, T., Knauf, C., & Valet, P. (2011) · Endocrine · doi:10.1007/s12020-011-9507-9 · Cited by 297

Adipokines – removing road blocks to obesity and diabetes therapy

Blüher, M. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.005 · Cited by 273

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

Drucker, D. J. (2013) · Diabetes · doi:10.2337/db13-0822 · Cited by 272

Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals

Moon, H., Dalamaga, Μ., Kim, S. Y., Pοlyzos, S. A., Hamnvik, O. R., Magkos, F., Paruthi, J., & Mantzoros, C. S. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1053 · Cited by 265

T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

Dalmas, É., Venteclef, N., Caer, C., Poitou, C., Cremer, I., Aron‐Wisnewsky, J., Lacroix‐Desmazes, S., Bayry, J., Kaveri, S. V., Clément, K., et al. (2014) · Diabetes · doi:10.2337/db13-1511 · Cited by 256

Adiponectin, driver or passenger on the road to insulin sensitivity?

Ye, R., & Scherer, P. E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.001 · Cited by 251

Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes

Lehr, S., Hartwig, S., Lamers, D., Famulla, S., Müller, S., Hanisch, F., Cuvelier, C. A., Ruige, J. B., Eckardt, K., Ouwens, D. M., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010504 · Cited by 249

Number and size of adipose tissue fat cells in relation to metabolism in human obesity

Björntorp, P. A., & Sjöström, L. (1971) · Metabolism · doi:10.1016/0026-0495(71)90084-9 · Cited by 243

Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity

Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., Schön, M. R., Shang, E., Lohmann, T., Dreßler, M., et al. (2011) · Metabolism · doi:10.1016/j.metabol.2011.10.008 · Cited by 234

Adipokines in gestational diabetes

Fasshauer, M., Blüher, M., & Stumvoll, M. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70176-1 · Cited by 230

Weekly Subcutaneous Pegylated Recombinant Native Human Leptin (PEG-OB) Administration in Obese Men

Hukshorn, C. J., Saris, W. H. M., Westerterp-Plantenga, M. S., Farid, A. R., Smith, F. J., & Campfield, L. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6955 · Cited by 220

Adipose Dipeptidyl Peptidase-4 and Obesity

Sell, H., Blüher, M., Klöting, N., Schlich, R., Willems, M., Ruppe, F., Knoefel, W. T., Dietrich, A., Fielding, B. A., Arner, P., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0496 · Cited by 219

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Gustafson, B., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Svensson, P., Grimsby, J. S., Rondinone, C. M., & Smith, U. (2015) · Diabetes · doi:10.2337/db14-1127 · Cited by 219

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

Gao, D., Madi, M., Ding, C., Fok, M., Steele, T., Ford, C. T., Hunter, L., & Chen, B. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2013 · Cited by 216

The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice

Winzell, M. S., Magnusson, C., & Åhrén, B. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.05.004 · Cited by 212

The role of adipokines in β-cell failure of type 2 diabetes

Dunmore, S., & Brown, J. E. P. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0278 · Cited by 212

Clinical Relevance of Adipokines

Blüher, M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.5.317 · Cited by 210

Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives

Dalamaga, Μ., Chou, S. H.-H., Shields, K. S., Papageorgiou, P., Pοlyzos, S. A., & Mantzoros, C. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.010 · Cited by 199

Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family

Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 199

Inventing new medicines: The FGF21 story

Kharitonenkov, A., & Adams, A. C. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.003 · Cited by 198

FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases

Itoh, N. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00107 · Cited by 198

Vaspin in obesity and diabetes: pathophysiological and clinical significance

Blüher, M. (2011) · Endocrine · doi:10.1007/s12020-011-9572-0 · Cited by 195

Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms

Yue, P., Jin, H. H., Xu, S., Aillaud, M., Deng, A. C., Azuma, J., Kundu, R. K., Reaven, G. M., Quertermous, T., & Tsao, P. S. (2010) · Endocrinology · doi:10.1210/en.2010-0576 · Cited by 171

Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue

Youn, B., Bang, S. I., Klöting, N., Park, J. W., Lee, N., Oh, J.-E., Pi, K., Lee, T. H., Ruschke, K., Faßhauer, M., et al. (2008) · Diabetes · doi:10.2337/db08-1147 · Cited by 171

The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study

Vaccaro, A. R., Whang, P. G., Patel, T. C., Phillips, F. M., Anderson, D. G., Albert, T. J., Hilibrand, A. S., Brower, R. S., Kurd, M. F., Appannagari, A., et al. (2007) · The Spine Journal · doi:10.1016/j.spinee.2007.03.012 · Cited by 169

Vaspin inhibits kallikrein 7 by serpin mechanism

Heiker, J. T., Klöting, N., Kovacs, P. L., Kuettner, E. B., Sträter, N., Schultz, S., Kern, M., Stümvoll, M., Blüher, M., & Beck‐Sickinger, A. G. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1258-8 · Cited by 166

Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject

Laurencikiene, J., Skurk, T., Kulyté, A., Hedén, P., Åström, G., Sjölin, E., Rydén, M., Hauner, H., & Arner, P. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1702 · Cited by 164

Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects

Klöting, N., Kovacs, P. L., Kern, M., Heiker, J. T., Faßhauer, M., Schön, M. R., Stümvoll, M., Beck‐Sickinger, A. G., & Blüher, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2137-1 · Cited by 160

Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration

Okamoto, M., Ohara‐Imaizumi, M., Kubota, N., Hashimoto, S., Eto, K., Kanno, T., Kubota, T., Wakui, M., Nagai, R., Noda, M., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-0944-9 · Cited by 156

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

Schulz, T. J., & Tseng, Y.-H. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.019 · Cited by 154

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

Gustafson, B., & Smith, U. (2012) · Diabetes · doi:10.2337/db11-1419 · Cited by 147

Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up‐regulated by hypoxia in human adipocytes and smooth muscle cells

Röhrborn, D., Eckel, J., & Sell, H. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.08.029 · Cited by 141

Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation

Flehmig, G., Scholz, M. R., Klöting, N., Faßhauer, M., Tönjes, A., Stümvoll, M., Youn, B., & Blüher, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099785 · Cited by 140

Adipocyte Size Threshold Matters: Link with Risk of Type 2 Diabetes and Improved Insulin Resistance After Gastric Bypass

Cotillard, A., Poitou, C., Torcivia, A., Bouillot, J., Dietrich, A., Klöting, N., Grégoire, C., Lolmède, K., Blüher, M., & Clément, K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1074 · Cited by 139

The genetics of fat distribution

Schleinitz, D., Böttcher, Y., Blüher, M., & Kovacs, P. (2014) · Diabetologia · doi:10.1007/s00125-014-3214-z · Cited by 134

Effects of Weight Loss and Exercise on Apelin Serum Concentrations and Adipose Tissue Expression in Human Obesity

Krist, J., Wieder, K., Klöting, N., Oberbach, A., Kralisch, S., Wiesner, T., Schön, M. R., Gärtner, D., Dietrich, A., Shang, E., et al. (2013) · Obesity Facts · doi:10.1159/000348667 · Cited by 124

Association between adiponectin levels and coronary heart disease and mortality: a systematic review and meta-analysis

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Obesity and Type 2 Diabetes are Associated with an Increased Risk of Developing Cancer and a Worse Prognosis; Epidemiological and Mechanistic Evidence

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