The DOI matches its Crossref record; 103 of the 104 references it cites were found in a registry or an index.
Adipokines in health and disease
Abstract
Obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several malignant diseases and, therefore, may contribute to shortened lifespan. Adipokines are peptides that signal the functional status of adipose tissue to targets in the brain, liver, pancreas, immune system, vasculature, muscle, and other tissues. Secretion of adipokines, including leptin, adiponectin, fibroblast growth factor 21 (FGF21), retinol-binding protein 4 (RBP4), dipeptidyl peptidase 4 (DPP-4), bone morphogenetic protein (BMP)-4, BMP-7, vaspin, apelin, and progranulin, is altered in adipose tissue dysfunction and may contribute to a spectrum of obesity-associated diseases. Adipokines are promising candidates both for novel pharmacological treatment strategies and as diagnostic tools, provided that we can develop a better understanding of the function and molecular targets of the more recently discovered adipokines.
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“This finding that adiponectin levels are proportional to metabolic fitness has prompted the use of recombinant adiponectin and other adiponectin receptor agonists in several mouse models of obesity.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [12]
In the citing paper
“Alternatively, mouse models of obesity and unhealthy obese individuals exhibit lower circulating levels of adiponectin.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [12]
In the citing paper
“So far, the activation of adiponectin signaling has improved glucose tolerance, insulin sensitivity, and longevity in mice 12, 130.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [12]
In the citing paper
“In conditions of insulin resistance, WAT secretome is substantially altered and includes a broad range of proinflammatory factors, such as TNF‐α, IL‐6, interleukin 8 (IL‐8), and interleukin 1β (IL‐1B) and monocyte chemotactic protein 1 (MCP1) 12.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [12]
In the citing paper
“The secretion of these proinflammatory cytokines and chemokines, as well as the secretion of other adipokines like retinol binding protein 4 (RBP4) 141, 142, is now well admitted to contribute to the onset of the physiological alterations accompanying obesity 12.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [12]
In the citing paper
“However, the use of leptin analogs in combination with other agents, namely amylin, has given more encouraging results, but was stopped due to adverse secondary effects 12.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [12]
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Metadata
- Authors
- Fasshauer, M., & Blüher, M.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Blüher, Matthias
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 36
- Issue
- 7
- Pages
- 461-470
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W1513674275
- Cited by
- 1,050
- References
- 104
- Citations by year
- 2026: 55 · 2025: 82 · 2024: 94 · 2023: 142 · 2022: 141 · 2021: 114 · 2020: 105 · 2019: 88 · 2018: 84 · 2017: 63 · 2016: 59 · 2015: 20
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- adipokines, obesity, adipose tissue dysfunction, leptin, adiponectin, FGF21, retinol-binding protein 4, dipeptidyl peptidase IV, bone morphogenetic proteins, vaspin, apelin, progranulin, obesity-related comorbidities, metabolic disorders, cardiovascular disease, chronic inflammation, cancer, pharmacotherapy, diagnostic biomarkers
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Humans, Obesity, Biomarkers, Adipokines
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