Cited by 155Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Psychedelic Drugs in Biomedicine

Kyzar, Evan J., Nichols, Charles D., Gainetdinov, Raul R., Nichols, David E., Kalueff, Allan V.·2017·Trends in Pharmacological Sciences

Abstract

Psychedelic drugs, such as lysergic acid diethylamide (LSD), mescaline, and psilocybin, exert profound effects on brain and behavior. After decades of difficulties in studying these compounds, psychedelics are again being tested as potential treatments for intractable biomedical disorders. Preclinical research of psychedelics complements human neuroimaging studies and pilot clinical trials, suggesting these compounds as promising treatments for addiction, depression, anxiety, and other conditions. However, many questions regarding the mechanisms of action, safety, and efficacy of psychedelics remain. Here, we summarize recent preclinical and clinical data in this field, discuss their pharmacological mechanisms of action, and outline critical areas for future studies of psychedelic drugs, with the goal of maximizing the potential benefits of translational psychedelic biomedicine to patients.

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Crossref · 10.1016/j.tips.2017.08.003

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Authors
Kyzar, E. J., Nichols, C. D., Gainetdinov, R. R., Nichols, D. E., & Kalueff, A. V.
Affiliations
  • University of Illinois Chicago (US)
  • Louisiana State University Health Sciences Center New Orleans (US)
  • Skolkovo Institute of Science and Technology (RU)
  • University of North Carolina at Chapel Hill (US)
  • Ural Federal University (RU)
Corresponding author
  • Kyzar, Evan J.
  • Kalueff, Allan V.
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2017-11
Volume
38
Issue
11
Pages
992-1005
ISSN
0165-6147 (ISSN-L)
OpenAlex
W2757917284
Cited by
155
References
88
Citations by year
2026: 8 · 2025: 14 · 2024: 14 · 2023: 15 · 2022: 22 · 2021: 24 · 2020: 23 · 2019: 13 · 2018: 21
FWCI
2.29
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Russian Science Foundation (14-50-00069)
  • Russian Foundation for Basic Research (16-04-00851)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
psychedelics, LSD, mescaline, psilocybin, addiction treatment, depression, anxiety, mechanism of action, drug safety and efficacy, neuroimaging
MeSH terms
Animals, Brain, Hallucinogens, Humans, Psychophysiology, Mind-Body Relations, Metaphysical

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