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Cited by 236Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesNeuroendocrine regulation and behavior

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The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation

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Zuloaga, Damian G., Puts, David A., Jordan, Cynthia L., Breedlove, S. Marc·2008·Hormones and Behavior
DOI 10.1016/j.yhbeh.2008.01.013PMC PMC2706155
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Abstract

Many studies demonstrate that exposure to testicular steroids such as testosterone early in life masculinizes the developing brain, leading to permanent changes in behavior. Traditionally, masculinization of the rodent brain is believed to depend on estrogen receptors (ERs) and not androgen receptors (ARs). According to the aromatization hypothesis, circulating testosterone from the testes is converted locally in the brain by aromatase to estrogens, which then activate ERs to masculinize the brain. However, an emerging body of evidence indicates that the aromatization hypothesis cannot fully account for sex differences in brain morphology and behavior, and that androgens acting on ARs also play a role. The testicular feminization mutation (Tfm) in rodents, which produces a nonfunctional AR protein, provides an excellent model to probe the role of ARs in the development of brain and behavior. Tfm rodent models indicate that ARs are normally involved in the masculinization of many sexually dimorphic brain regions and a variety of behaviors, including sexual behaviors, stress response and cognitive processing. We review the role of ARs in the development of the brain and behavior, with an emphasis on what has been learned from Tfm rodents as well as from related mutations in humans causing complete androgen insensitivity.

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Metadata

Authors
Zuloaga, D. G., Puts, D. A., Jordan, C. L., & Breedlove, S. M.
Affiliations
  • Michigan State University (US)
  • Pennsylvania State University (US)
Corresponding author
Zuloaga, Damian G.
ORCID
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2008-05
Volume
53
Issue
5
Pages
613-626
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2008.01.013
PMC
PMC2706155
OpenAlex
W1990168204
Cited by
236
References
0
Citations by year
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FWCI
6.99
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (F31MH078273, F31 MH78273)
  • National Institute of Neurological Disorders and Stroke (R01NS028421, R01-NS28421, R01NS045195)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
androgen receptor, aromatase, estrogen receptor, sex differences in brain, sexual behavior, stress response, cognitive processes, androgen insensitivity syndrome, brain development
MeSH terms
Aggression, Animals, Behavior, Animal, Brain, Female, Feminization, Humans, Male, Mutation, Receptors, Androgen, Sex Differentiation, Social Behavior

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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