Social and novel contexts modify hippocampal CA2 representations of space
Open accessAbstract
The hippocampus supports a cognitive map of space and is critical for encoding declarative memory (who, what, when and where). Recent studies have implicated hippocampal subfield CA2 in social and contextual memory but how it does so remains unknown. Here we find that in adult male rats, presentation of a social stimulus (novel or familiar rat) or a novel object induces global remapping of place fields in CA2 with no effect on neuronal firing rate or immediate early gene expression. This remapping did not occur in CA1, suggesting this effect is specific for CA2. Thus, modification of existing spatial representations might be a potential mechanism by which CA2 encodes social and novel contextual information.
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CA2 pyramidal cell activity remapped during social interactions, but unlike CA1 pyramidal cell activity, did not remap to changes in spatial cues.
“Furthermore, CA2 pyramidal cell activity remapped during social interactions, but unlike CA1 pyramidal cell activity, did not remap to changes in spatial cues [74].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [74]
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- Authors
- Alexander, G. M., Farris, S., Pirone, J. R., Zheng, C., Colgin, L. L., & Dudek, S. M.
- Affiliations
- National Institutes of Health (US)
- Social and Scientific Systems (United States) (US)
- The University of Texas at Austin (US)
- Corresponding author
- Dudek, Serena M.
- Venue
- Nature Communications
- Published
- 2016-01-25
- Volume
- 7
- Issue
- 1
- Pages
- 10300-10300
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4737730
- OpenAlex
- W2264119724
- Cited by
- 191
- References
- 62
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 19 · 2023: 21 · 2022: 22 · 2021: 25 · 2020: 16 · 2019: 16 · 2018: 29 · 2017: 12 · 2016: 4
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- VTechWorks (Virginia Tech) (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- Office of Naval Research (N00014, N00014-14-1-0322)
- National Institute of Mental Health (R01MH102450, N00014-14-1-0322)
- National Institute of Environmental Health Sciences (ES100221, Z01ES100221)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal CA2, place fields, spatial representation, cognitive maps, social memory, contextual memory, novel object recognition, place field remapping, CA1, immediate early gene expression, rats
- MeSH terms
- Animals, Behavior, Animal, Male, Memory, Neurons, Space Perception, Rats, Sprague-Dawley, Rats, CA2 Region, Hippocampal, Social Skills
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