Vasopressin 1b Receptor Knock-Out Impairs Memory for Temporal Order
Open accessAbstract
Mice lacking a functional vasopressin 1b receptor (Avpr1b) display decreased levels of aggression and social memory. Here, we used Avpr1b-knock-out (Avpr1b−/−) mice to examine whether an abnormality of this receptor results in specific cognitive deficits in the domain of hippocampal function. Avpr1b−/−mice were deficient in sociability and in detecting social novelty, extending previous findings of impairment in social recognition in these mutants. Avpr1b−/−mice could recognize previously explored objects and remember where they were experienced, but they were impaired in remembering the temporal order of presentation of those objects. Consistent with this finding, Avpr1b−/−mice were also impaired on an object–odor paired associate task that involved a temporal discontiguity between the associated elements. Finally, Avpr1b−/−mice performed normally in learning a set of overlapping odor discriminations and could infer relationships among odors that were only indirectly associated (i.e., transitive inference), indicating intact relational memory. The Avpr1b is expressed at much higher levels than any other part of the brain in the pyramidal cells of hippocampal CA2 area, a subfield of the hippocampus that has physiological and genetic properties that distinguish it from subfields CA1 and CA3. The combined results suggest that the Avpr1b, perhaps in CA2, may play a highly specific role in social behavior and episodic memory. Because schizophrenia and bipolar disorder are associated with a unique pathology in CA2 and impairments in both social behavior and episodic memory, this animal model could provide insights into the etiology of these disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Unconditional deletion of Avpr1b impairs social recognition memory.
“unconditional deletion of this gene impairs social recognition memory22,23.”
From The hippocampal CA2 region is essential for social memory (2014) · cites this paper as [23]
CA2-TeNT mice displayed a profound deficit in social recognition in the three-chamber social novelty test.
“CA2-TeNT mice displayed a profound deficit in social recognition as determined by a three-chamber social novelty test23 (Fig. 4b).”
From The hippocampal CA2 region is essential for social memory (2014) · cites this paper as [23]
Avpr1b mRNA is also expressed outside hippocampus, and its deletion results in changes in non-hippocampal dependent behaviors, including reduced aggression and decreased sociability.
“However, Avpr1b mRNA is also expressed outside hippocampus21 and its deletion results in changes in non-hippocampal dependent behaviors, including reduced aggression and decreased sociability22,23”
From The hippocampal CA2 region is essential for social memory (2014) · cites this paper as [23]
Mice lacking the vasopressin V1b receptor show a selective impairment in episodic memory of the temporal order of events.
“Thus, mice lacking the vasopressin V1b receptor, which is highly expressed in CA2 neurons (Young et al., 2006), show a selective impairment in episodic memory of the temporal order of events (DeVito et al., 2009).”
From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as DeVito et al., 2009
Transgenic mice with vasopressin 1b knockout exhibited deficient sociability and social novelty in the three-chambered social test and impaired when memory in the ELM2-1 test.
“Transgenic mice with vasopressin 1b knockout exhibited deficient sociability and social novelty assessed by the three-chambered social test, and impaired when memory in the ELM2–1 test.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as DeVito et al., 2009
Because vasopressin 1b is highly expressed in hippocampal CA2, CA2 vasopressin 1b could be associated with social behaviors and episodic memory.
“the CA2 vasopressin 1b could be associated with social behaviors and episodic memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as DeVito et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · cited 2× · see citing works
“The social recognition paradigm was adapted from that of Moy et al. (2004).”
BackgroundMethodSpatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985 · see citing works
Critical role of the hippocampus in memory for sequences of events
Fortin, N. J., Agster, K. L., & Eichenbaum, H. B. (2002) · Nature Neuroscience · doi:10.1038/nn834 · Cited by 881 · see citing works
Self-citationDistinct Ensemble Codes in Hippocampal Areas CA3 and CA1
Leutgeb, S., Leutgeb, J. K., Treves, A., Moser, M., & Moser, E. I. (2004) · Science · doi:10.1126/science.1100265 · Cited by 774 · see citing works
Conservation of hippocampal memory function in rats and humans
Bunsey, M. D., & Eichenbaum, H. (1996) · Nature · doi:10.1038/379255a0 · Cited by 733 · see citing works
Self-citationThe hippocampus and memory for orderly stimulus relations
Dusek, J. A., & Eichenbaum, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7109 · Cited by 610 · see citing works
Self-citationImpaired recruitment of the hippocampus during conscious recollection in schizophrenia
Heckers, S., Rauch, S., Goff, D., Savage, C., Schacter, D., Fischman, A., & Alpert, N. (1998) · Nature Neuroscience · doi:10.1038/1137 · Cited by 570 · see citing works
Impaired recruitment of the hippocampus during conscious recollection in schizophrenia
Heckers, S., Rauch, S. L., GOFF, D. C., Savage, C. R., Schacter, D. L., Fischman, A. J., & Alpert, N. M. (1998) · NeuroImage · doi:10.1016/s1053-8119(18)30930-3 · Cited by 492 · see citing works
A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
Benes, F. M., Kwok, E. W., Vincent, S. L., & Todtenkopf, M. S. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00138-3 · Cited by 470 · see citing works
Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
Wersinger, S. R., Ginns, E. I., O'Carroll, A.-M., Lolait, S. J., & Young III, W. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001195 · Cited by 397 · see citing works
Self-citationCell biology of the hippocampal formation in schizophrenia
Weinberger, D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00331-x · Cited by 321 · see citing works
The Hippocampus and Memory for “What,” “Where,” and “When”
Ergorul, C., & Eichenbaum, H. (2004) · Learning & Memory · doi:10.1101/lm.73304 · Cited by 294 · see citing works
Self-citationHippocampal activation during transitive inference in humans
Heckers, S., Zalesak, M., Weiss, A. P., Ditman, T., & Titone, D. A. (2004) · Hippocampus · doi:10.1002/hipo.10189 · Cited by 269 · see citing works
Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2005) · Brain Research Protocols · doi:10.1016/j.brainresprot.2005.08.001 · Cited by 242 · see citing works
Young, W. S., Li, J., Wersinger, S. R., & Palkovits, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.040 · Cited by 222 · see citing works
Self-citationEntorhinal Cortex Lesions Disrupt the Relational Organization of Memory in Monkeys
Buckmaster, C. A., Eichenbaum, H., Amaral, D. G., SUZUKI, W. A., & Rapp, P. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1532-04.2004 · Cited by 198 · see citing works
Self-citationSynaptic Plasticity (and the Lack Thereof) in Hippocampal CA2 Neurons
Zhao, M., Choi, Y., Obrietan, K. H., & Dudek, S. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4094-07.2007 · Cited by 181 · see citing works
Social functioning and neurocognitive deficits in outpatients with schizophrenia: a 2-year follow-up
Dickerson, F. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00134-0 · Cited by 178 · see citing works
The vasopressin system — From antidiuresis to psychopathology
Frank, E., & Landgraf, R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.063 · Cited by 159 · see citing works
Transitive inference in schizophrenia: impairments in relational memory organization
Titone, D. A. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00152-x · Cited by 139 · see citing works
Wersinger, S. R., Kelliher, K. R., Zufall, F., Lolait, S. J., O’Carroll, A., & Young, W. S. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.07.004 · Cited by 132 · see citing works
Self-citationGilbert, P. E., & Kesner, R. P. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.1.63 · Cited by 132 · see citing works
Wersinger, S. R., Caldwell, H. K., Christiansen, M., & Young, W. S. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00294.x · Cited by 130 · see citing works
Self-citationThe Role of CA1 in the Acquisition of an Object-Trace-Odor Paired Associate Task.
Kesner, R. P., Hunsaker, M. R., & Gilbert, P. E. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.3.781 · Cited by 121 · see citing works
Characterization of Neurons in the CA2 Subfield of the Adult Rat Hippocampus
Mercer, A., Trigg, H. L., & Thomson, A. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1829-07.2007 · Cited by 113 · see citing works
Rolls, E. T., & Treves, A. (1997) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198524328.003.0006 · Cited by 112 · see citing works
Wersinger, S. R., Temple, J. L., Caldwell, H. K., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1056 · Cited by 83 · see citing works
Self-citationDelayed Signal Propagation via CA2 in Rat Hippocampal Slices Revealed by Optical Recording
Sekino, Y., Obata, K., Tanifuji, M., Mizuno, M., & Murayama, J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.3.1662 · Cited by 69 · see citing works
The role of the vasopressin 1b receptor in aggression and other social behaviours
CALDWELL, H., WERSINGER, S., & YOUNGIII, W. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00406-8 · Cited by 64 · see citing works
Self-citationEnhanced context-dependency of object recognition in rats with hippocampal lesions
OBRIEN, N., LEHMANN, H., Lecluse, V., & Mumby, D. G. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.02.008 · Cited by 59 · see citing works
Executive function of the hippocampus in social behavior in the rat.
Maaswinkel, H., Gispen, W. H., & Spruijt, B. M. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.4.777 · Cited by 42 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The hippocampal CA2 region is essential for social memory
Hitti, F. L., & Siegelbaum, S. A. (2014) · Nature · doi:10.1038/nature13028 · Cited by 976 · see citing works
Time cells in the hippocampus: a new dimension for mapping memories
Eichenbaum, H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3827 · Cited by 843 · see citing works
Self-citationVasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 413 · see citing works
Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
Mumtaz, F., Khan, M. I., Zubair, M., & Dehpour, A. R. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.086 · Cited by 369 · see citing works
Rediscovering area CA2: unique properties and functions
Dudek, S. M., Alexander, G. M., & Farris, S. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2015.22 · Cited by 329 · see citing works
Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop
Chevaleyre, V., & Siegelbaum, S. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.013 · Cited by 324 · see citing works
A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics
Meira, T., Leroy, F., Buss, E. W., Oliva, A., Park, J., & Siegelbaum, S. A. (2018) · Nature Communications · doi:10.1038/s41467-018-06501-w · Cited by 310 · see citing works
Hippocampal CA2 activity patterns change over time to a larger extent than between spatial contexts
Mankin, E. A., Diehl, G. W., Sparks, F. T., Leutgeb, S., & Leutgeb, J. K. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.001 · Cited by 279 · see citing works
The Corticohippocampal Circuit, Synaptic Plasticity, and MemoryPreprint
Basu, J., & Siegelbaum, S. A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021733 · Cited by 244 · see citing works
Targeted activation of the hippocampal CA2 area strongly enhances social memory
Smith, A. S., Williams Avram, S. K., Cymerblit-Sabba, A., Song, J., & Young, W. S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.189 · Cited by 236 · see citing works
Self-citationSchwartzer, J. J., Careaga, M., Onore, C. E., Rushakoff, J. A., Berman, R. F., & Ashwood, P. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.16 · Cited by 227 · see citing works
Lee, S. E., Simons, S. B., Heldt, S. A., Zhao, M., Schroeder, J. P., Vellano, C. P., Cowan, D. P., Ramineni, S., Yates, C. K., Feng, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005362107 · Cited by 224 · see citing works
Lesions to the <scp>CA</scp>2 region of the hippocampus impair social memory in mice
Stevenson, E. L., & Caldwell, H. K. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12689 · Cited by 222 · see citing works
Hypothalamic and other connections with dorsal CA2 area of the mouse hippocampus
Cui, Z., Gerfen, C. R., & Young, W. S. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23263 · Cited by 214 · see citing works
Self-citationAn intrinsic vasopressin system in the olfactory bulb is involved in social recognition
Tobin, V. A., Hashimoto, H., Wacker, D. W., Takayanagi, Y., Langnaese, K., Caquineau, C., Noack, J., Landgraf, R., Onaka, T., Leng, G., et al. (2010) · Nature · doi:10.1038/nature08826 · Cited by 213 · see citing works
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice
Stankiewicz, A. M., Gościk, J., Majewska, A., Swiergiel, A. H., & Juszczak, G. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142195 · Cited by 138 · see citing works
Updating hippocampal representations: CA2 joins the circuit
Jones, M. W., & McHugh, T. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.007 · Cited by 137 · see citing works
Adamowicz, D. H., Roy, S., Salmon, D. P., Galasko, D. R., Hansen, L. A., Masliah, E., & Gage, F. H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3047-16.2016 · Cited by 126 · see citing works
Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders
Rubin, L. H., Carter, C. S., Bishop, J. R., Pournajafi-Nazarloo, H., Drogos, L. L., Hill, S. K., Ruocco, A. C., Keedy, S. K., Reilly, J. L., Keshavan, M. S., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu027 · Cited by 127 · see citing works
Social Memory and the Role of the Hippocampal CA2 Region
Tzakis, N., & Holahan, M. R. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00233 · Cited by 122 · see citing works
The vasopressin Avpr1b receptor: Molecular and pharmacological studies
Roper, J. A., O'Carroll, A.-M., Young, W. S., & Lolait, S. (2010) · Stress · doi:10.3109/10253890.2010.512376 · Cited by 116 · see citing works
Self-citationSerine racemase deletion disrupts memory for order and alters cortical dendritic morphology
DeVito, L. M., Balu, D. T., Kanter, B. R., Lykken, C., Basu, A. C., COYLE, J. T., & Eichenbaum, H. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00656.x · Cited by 114 · see citing works
Self-citationDeveloping treatments for cognitive deficits in schizophrenia: The challenge of translation
Young, J. W., & Geyer, M. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114555252 · Cited by 110 · see citing works
The vasopressin 1b receptor and the neural regulation of social behavior
Stevenson, E. L., & Caldwell, H. K. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.009 · Cited by 100 · see citing works
Sala, M., Braida, D., Donzelli, A., Martucci, R., Busnelli, M., Bulgheroni, E., Rubino, T., Parolaro, D., Nishimori, K., & Chini, B. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02385.x · Cited by 99 · see citing works
Social memory engram in the hippocampus
Okuyama, T. (2018) · Neuroscience Research · doi:10.1016/j.neures.2017.05.007 · Cited by 95 · see citing works
Social memories in rodents: Methods, mechanisms and modulation by stress
van der Kooij, M. A., & Sandi, C. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.006 · Cited by 92 · see citing works
Oxytocin and vasopressin in the rodent hippocampus
Cilz, N. I., Cymerblit‐Sabba, A., & Young, W. S. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12535 · Cited by 88 · see citing works
Self-citationThe effects of acute social isolation on long-term social recognition memory
Leser, N., & Wagner, S. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.07.002 · Cited by 82 · see citing works
Sun, Q., Srinivas, K. V., Sotayo, A. O., & Siegelbaum, S. A. (2014) · eLife · doi:10.7554/elife.04551 · Cited by 79 · see citing works
CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing
Lehr, A. B., Kumar, A., Tetzlaff, C., Hafting, T., Fyhn, M., & Stöber, T. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.020 · Cited by 74 · see citing works
Caruana, D. A., Alexander, G. M., & Dudek, S. M. (2012) · Learning & Memory · doi:10.1101/lm.025304.111 · Cited by 76 · see citing works
The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders
Abramova, O. V., Zorkina, Y., Ushakova, V. M., Zubkov, E. A., Morozova, A. Y., & Chekhonin, V. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102079 · Cited by 74 · see citing works
Social anxiety disorder-associated gut microbiota increases social fear
Ritz, N. L., Brocka, M., Butler, M., Cowan, C. S. M., Barrera-Bugueño, C., Turkington, C. J. R., Draper, L. A., Bastiaanssen, T. F. S., Turpin, V., Morales, L., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2308706120 · Cited by 72 · see citing works
Hunsaker, M. R., & Kesner, R. P. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.11.012 · Cited by 68 · see citing works
Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia
O’Tuathaigh, C. M. P., Kirby, B. P., Moran, P. M., & Waddington, J. L. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp125 · Cited by 70 · see citing works
Linking Social Cognition to Learning and Memory
Leblanc, H., & Ramirez, S. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1280-20.2020 · Cited by 69 · see citing works
Piskorowski, R. A., & Chevaleyre, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0769-4 · Cited by 65 · see citing works
The hippocampus contributes to memory expression during transitive inference in mice
DeVito, L. M., Kanter, B. R., & Eichenbaum, H. (2009) · Hippocampus · doi:10.1002/hipo.20610 · Cited by 65 · see citing works
Self-citationCognitive and social functions and growth factors in a mouse model of Rett syndrome
Schaevitz, L. R., Moriuchi, J. M., Nag, N., Mellott, T. J., & Berger-Sweeney, J. E. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.025 · Cited by 65 · see citing works
Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 63 · see citing works
Sociability and brain development in BALB/cJ and C57BL/6J mice
Fairless, A. H., Dow, H. C., Kreibich, A. S., Torre, M., Kuruvilla, M., Gordon, E., Morton, E. A., Tan, J., Berrettini, W. H., Li, H., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.001 · Cited by 60 · see citing works
Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain
Evans, P. R., Lee, S. E., Smith, Y., & Hepler, J. R. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23395 · Cited by 60 · see citing works
Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit
Benoy, A., Dasgupta, A., & Sajikumar, S. (2018) · Experimental Brain Research · doi:10.1007/s00221-018-5187-5 · Cited by 57 · see citing works
Binder, S., Dere, E., & Zlomuzica, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.04.002 · Cited by 53 · see citing works
Pang, C. C.-C., Kiecker, C. M., O'Brien, J. T., Noble, W. J., & Chang, R. C. (2018) · The Neuroscientist · doi:10.1177/1073858418778747 · Cited by 56 · see citing works
Maki, R. A., Holzer, M., Motamedchaboki, K., Malle, E., Masliah, E., Marsche, G., & Reynolds, W. F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.033 · Cited by 56 · see citing works
Gene Network Effects on Brain Microstructure and Intellectual Performance Identified in 472 Twins
Chiang, M., Marina Barysheva, A., McMahon, K. L., de Zubicaray, G. I., Johnson, K., Montgomery, G. W., Martin, N. G., Toga, A. W., Wright, M. J., Shapshak, P., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5993-11.2012 · Cited by 55 · see citing works
Stachowiak, M. K., Kucinski, A. J., Curl, R., Syposs, C., Yang, Y., Narla, S. T., Terranova, C. J., Prokop, D., Klejbor, I., Bencherif, M., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.004 · Cited by 53 · see citing works
Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory
MacDonald, C. J., & Tonegawa, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020698118 · Cited by 52 · see citing works
Cognitive Abilities on Transitive Inference Using a Novel Touchscreen Technology for Mice
Silverman, J. L., Gastrell, P. T., Karras, M. N., Solomon, M., & Crawley, J. N. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht293 · Cited by 49 · see citing works
Pan, L., Zheng, L., Wu, X., Zhu, Z., Wang, S., Lu, Y., He, Y., Yang, Q., Ma, X., Wang, X., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01692-7 · Cited by 49 · see citing works
Distinct functions of ventral CA1 and dorsal CA2 in social memory
Watarai, A., Tao, K., Wang, M., & Okuyama, T. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.008 · Cited by 46 · see citing works
Local circuitry involving parvalbumin‐positive basket cells in the CA2 region of the hippocampus
Mercer, A., Eastlake, K., Trigg, H. L., & Thomson, A. M. (2010) · Hippocampus · doi:10.1002/hipo.20841 · Cited by 45 · see citing works
Proximodistal Organization of the CA2 Hippocampal Area
Fernández‐Lamo, I., Gómez-Domínguez, D., Sánchez-Aguilera, A., Oliva, A., Morales, A. V., Valero, M., Cid, E., Berényi, A., & de la Prida, L. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2019.01.060 · Cited by 45 · see citing works
Beer, Z., Vavra, P., Atucha, E., Rentzing, K., Heinze, H.-J., & Sauvage, M. M. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006100 · Cited by 44 · see citing works
Self-citationRegulation of Social Recognition Memory in the Hippocampal Circuits
Wang, X., & Zhan, Y. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.839931 · Cited by 44 · see citing works
D’Souza, M. S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00509 · Cited by 46 · see citing works
Neural Activity Patterns Underlying Spatial Coding in the Hippocampus
Sosa, M., Gillespie, A. K., & Frank, L. M. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_462 · Cited by 39 · see citing works
Social Context, Stress, Neuropsychiatric Disorders, and the Vasopressin 1b Receptor
Caldwell, H. K., Aulino, E. A., Rodriguez, K. M., Witchey, S. K., & Yaw, A. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00567 · Cited by 39 · see citing works
SorCS2 is required for social memory and trafficking of the NMDA receptor
Yang, J., Ma, Q., Dincheva, I., Giza, J. I., Jing, D., Marinic, T. E., Milner, T. A., Rajadhyaksha, A. M., Lee, F. S., & Hempstead, B. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0650-7 · Cited by 35 · see citing works
Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area
Chafaï, M., Corbani, M., Guillon, G., & Desarménien, M. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049708 · Cited by 32 · see citing works
Zhang, X., Zhao, F., Wang, C., Zhang, J., Bai, Y., Zhou, F., Wang, Z.-J., Wu, M., Yang, W., Guo, J., et al. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00434-0 · Cited by 31 · see citing works
Conspecific Interactions in Adult Laboratory Rodents: Friends or Foes?
Lukas, M., & A, T. R. D. J. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_428 · Cited by 29 · see citing works
Evans, P. R., Gerber, K. J., Dammer, E. B., Duong, D. M., Goswami, D., Lustberg, D. J., Zou, J., Yang, J. J., Dudek, S. M., Griffin, P. R., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00027 · Cited by 27 · see citing works
Regulator of G Protein Signaling 14
Evans, P. R., Dudek, S. M., & Hepler, J. R. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.03.006 · Cited by 26 · see citing works
Yeates, D. C. M., Ussling, A., Lee, A. C. H., & Ito, R. (2019) · Hippocampus · doi:10.1002/hipo.23182 · Cited by 25 · see citing works
Behavioral Animal Models to Assess Pro-cognitive Treatments for Schizophrenia
Young, J. W., Amitai, N., & Geyer, M. A. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25758-2_3 · Cited by 26 · see citing works
Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders
Hunsaker, M. R. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.12.001 · Cited by 25 · see citing works
Barsegyan, A., Atsak, P., Hornberger, W., Jacobson, P. B., van Gaalen, M. M., & Roozendaal, B. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.48 · Cited by 25 · see citing works
Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals
Adhikari, A., Das, M., Mondal, S., Darbar, S., Das, A. K., Bhattacharya, S. S., Pal, D., & Pal, S. K. (2019) · Biomaterials Science · doi:10.1039/c9bm01039d · Cited by 23 · see citing works
Williams Avram, S. K., Lee, H.-J., Fastman, J., Cymerblit-Sabba, A., Smith, A., Vincent, M., Song, J., Granovetter, M. C., Lee, S.-H., Cilz, N. I., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00218 · Cited by 22 · see citing works
Self-citationLiu, X., Cui, Y., Zhang, Y., Guo, X., Meng, Y., Wang, X., Qiu, B., Li, X., Liu, W., & Zhang, D. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113949 · Cited by 22 · see citing works
Stöber, T. M., Lehr, A. B., Hafting, T., Kumar, A., & Fyhn, M. (2020) · Hippocampus · doi:10.1002/hipo.23256 · Cited by 20 · see citing works
Vasopressin Proves Essential: Vasopressin and the Modulation of Sensory Processing in Mammals
Bester‐Meredith, J. K., Fancher, A. P., & Mammarella, G. E. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00005 · Cited by 23 · see citing works
Ma, W., Si, T., Wang, Z., Wen, P., Zhu, Z., Liu, Q., Wang, J., Xu, F., & Li, Q. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112674 · Cited by 24 · see citing works
Hippocampal Lnx1–NMDAR multiprotein complex mediates initial social memory
Liu, X.-D., Ai, P.-H., Zhu, X.-N., Pan, Y., Halford, M. M., Henkemeyer, M. J., Feng, D., Xu, T., Sun, S., & Xu, N. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0606-y · Cited by 21 · see citing works
Blázquez, G., Castañé, A., Saavedra, A., Masana, M., Alberch, J., & Pérez‐Navarro, E. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00317 · Cited by 20 · see citing works
Elgamal, M. A., Khodeer, D. M., Abdel‐Wahab, B. A., Ibrahim, I. A. A., Alzahrani, A. R., Moustafa, Y. M., Ali, A. A., & El-Sayed, N. M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1113966 · Cited by 20 · see citing works
Ji, P., Lönnerdal, B. L., Kim, K., & Jinno, C. N. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy227 · Cited by 20 · see citing works
Hisamatsu, K., Niwa, M., Kobayashi, K., Miyazaki, T., Hirata, A., Hatano, Y., Tomita, H., & Hara, A. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000538 · Cited by 20 · see citing works
Oxytocin and vasopressin in the hippocampus
Zăgrean, A., Georgescu, I.-A., Ieșanu, M. I., Ionescu, R.-B., Haret, R. M., Panaitescu, A. M., & Zăgrean, L. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2021.11.002 · Cited by 20 · see citing works
Richardson, T. E., Walker, J. M., Farrell, K. W., Oliveira, T. G., White, C. L., & Crary, J. F. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02943-x · Cited by 21 · see citing works
Probing the nature of episodic memory in rodents
Huston, J. P., & Chao, O. Y.-H. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104930 · Cited by 16 · see citing works
Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress
Raghuraman, R., Navakkode, S., & Sajikumar, S. (2023) · Hippocampus · doi:10.1002/hipo.23531 · Cited by 15 · see citing works
On the novel mechanisms for social memory and the emerging role of neurogenesis
Lunardi, P. S., Mansk, L. M. Z., Jaimes, L. F., & Pereira, G. S. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.03.006 · Cited by 16 · see citing works
Moszczynski, A. J., Harvey, M., Fulcher, N., de Oliveira, C., McCunn, P., Donison, N., Bartha, R., Schmid, S., Strong, M. J., & Volkening, K. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0816-1 · Cited by 15 · see citing works
Hunsaker, M. R. (2012) · Behavioral Neuroscience · doi:10.1037/a0028453 · Cited by 13 · see citing works
Hippocampus Modulates Vocalizations Responses at Early Auditory Centers
Leong, A. T. L., Wong, E. C., Wang, X., & Wu, E. X. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.119943 · Cited by 13 · see citing works
Mouse Behavior and Models for Autism Spectrum Disorders
Ricceri, L., Michetti, C., & Scattoni, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00017-0 · Cited by 11 · see citing works
Higuchi, Y., & Arakawa, H. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105128 · Cited by 9 · see citing works
Witchey, S. K., Stevenson, E. L., & Caldwell, H. K. (2016) · BMC Neuroscience · doi:10.1186/s12868-016-0310-7 · Cited by 9 · see citing works
Guo, R., Li, Y., Liu, J., Gong, S., & Liu, K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.723658 · Cited by 10 · see citing works
The involvement of oxytocin and vasopressin in social recognition and social learning
Dore, R., Phan, A., Clipperton‐Allen, A. E., Kavaliers, M., & Choleris, E. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.016 · Cited by 7 · see citing works
Yu, Y. H., Kim, S.-W., Im, H., Lee, Y. R., Kim, G. W., Ryu, S., Park, D., & Kim, D. (2023) · Cells · doi:10.3390/cells12202446 · Cited by 6 · see citing works
Identification of hippocampal area CA2 in hamster and vole brain
Siegler, P. N., Shaughnessy, E. K., Horman, B. M., Vierling, T. T., King, D. H., Patisaul, H. B., Huhman, K. L., Alexander, G. M., & Dudek, S. M. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.25603 · Cited by 6 · see citing works
Zhao, F., & Behnisch, T. (2023) · Biomedicines · doi:10.3390/biomedicines11071996 · Cited by 6 · see citing works
Piron, M. J., & Villereal, M. L. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24289 · Cited by 6 · see citing works
Vasopressin V1a and V1b receptor modulators: a patent review (2012 – 2014)
Ślusarz, M. J. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2015.1026257 · Cited by 6 · see citing works
- Authors
- DeVito, L. M., Konigsberg, R., Lykken, C., Sauvage, M., Young, W. S., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- United States Department of Health and Human Services (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-03-04
- Volume
- 29
- Issue
- 9
- Pages
- 2676-2683
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2671073
- OpenAlex
- W2111647450
- Cited by
- 147
- References
- 31
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 10 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 13 · 2017: 5 · 2016: 9 · 2015: 11 · 2014: 11 · 2013: 13 · 2012: 14
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (P50MH071702, Z01-MH-002498, Z01MH002498)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- temporal order memory, episodic memory, hippocampal CA2, social memory, social novelty, sociability, object recognition, transitive inference, relational memory, schizophrenia, bipolar disorder, aggression
- MeSH terms
- Animals, Association Learning, Conditioning, Operant, Discrimination, Psychological, Hippocampus, Memory Disorders, Mice, Inbred C57BL, Odorants, Social Perception, Receptors, Vasopressin, Pyramidal Cells, Mice, Knockout, Recognition, Psychology, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
