The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder
Abstract
Background Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms.Methods Twenty-four children between the ages of 7 and 14 with a history of trauma and PTSD symptoms were assessed with the Clinician-Administered PTSD Scale for Children and Adolescents (CAPS-CA). The sample underwent magnetic resonance imaging in a 1.5 T scanner. Brain images were analyzed by raters blind to diagnostic status using well-standardized methods, and images were compared with age- and gender-matched healthy control subjects.Results The clinical group demonstrated attenuation of frontal lobe asymmetry and smaller total brain and cerebral volumes when compared with the control group. There were no statistically significant differences in hippocampal volume between clinical and control subjects.Conclusions Frontal lobe abnormalities may occur as a result of PTSD in children or, alternatively, be a risk factor for the development of the syndrome in this age group. The implications of the findings and their consistency with previous research are discussed.
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“Several morphometric MRI studies have reported decreased volumes of frontal cortex in PTSD (Carrion et al., 2001;Fennema-Notestine et al., 2002).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Carrion et al., 2001
In the citing paper
“Decreased volumes of frontal cortex fMRI: Carrion et al. (2001); Fennema-Notestine et al. (2002)”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Carrion et al. (2001)
In the citing paper
“Researchers found more regularly that the medial prefrontal cortex was smaller and hyper-reactive during symptomatic conditions.”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Carrion et al. (2001)
In the citing paper
“Smaller total brain volume were found in children with posttraumatic stress compared with nonmaltreated youth (Carrion et al, 2001).”
From Deviations from the expectable environment in early childhood and emerging psychopathology (2015) · cites this paper as Carrion et al, 2001
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Metadata
- Authors
- Carrion, V. G., Weems, C. F., Eliez, S., Patwardhan, A., Brown, W., Ray, R. D., & Reiss, A. L.
- Affiliations
- Stanford Medicine (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 50
- Issue
- 12
- Pages
- 943-951
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2004069331
- Cited by
- 400
- References
- 46
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 13 · 2019: 12 · 2018: 5 · 2017: 16 · 2016: 26 · 2015: 26 · 2014: 22 · 2013: 21 · 2012: 32
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH 50047, R01MH050047)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- frontal lobe asymmetry, brain structure, total brain volume, brain volume, hippocampal volume, childhood trauma, neuroimaging findings
- MeSH terms
- Adolescent, Amygdala, Analysis of Variance, Brain, Child, Child Behavior, Child Development, Cognition, Female, Frontal Lobe, Hippocampus, Humans, Intelligence, Magnetic Resonance Imaging, Male, Stress Disorders, Post-Traumatic, Wechsler Scales, Case-Control Studies, Survivors
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