Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder
Open accessAbstract
Magnetic resonance imaging studies of maltreated children with posttraumatic stress disorder (PTSD) suggest that maltreatment-related PTSD is associated with adverse brain development. Maltreated youth resilient to chronic PTSD were not previously investigated and may elucidate neuromechanisms of the stress diathesis that leads to resilience to chronic PTSD. In this cross-sectional study, anatomical volumetric and corpus callosum diffusion tensor imaging measures were examined using magnetic resonance imaging in maltreated youth with chronic PTSD (N= 38), without PTSD (N= 35), and nonmaltreated participants (n= 59). Groups were sociodemographically similar. Participants underwent assessments for strict inclusion/exclusion criteria and psychopathology. Maltreated youth with PTSD were psychobiologically different from maltreated youth without PTSD and nonmaltreated controls. Maltreated youth with PTSD had smaller posterior cerebral and cerebellar gray matter volumes than did maltreated youth without PTSD and nonmaltreated participants. Cerebral and cerebellar gray matter volumes inversely correlated with PTSD symptoms. Posterior corpus callosum microstructure in pediatric maltreatment-related PTSD differed compared to maltreated youth without PTSD and controls. The group differences remained significant when controlling for psychopathology, numbers of Axis I disorders, and trauma load. Alterations of these posterior brain structures may result from a shared trauma-related mechanism or an inherent vulnerability that mediates the pathway from chronic PTSD to comorbidity.
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These brain regions and functional deficits have been specifically implicated in the development of psychiatric disorders such as depression, PTSD, BPD, schizophrenia, antisocial personality disorders, and substance use disorders.
“These brain regions and functional deficits have been specifically implicated in the development of psychiatric disorders such as depression, PTSD, BPD, schizophrenia, antisocial personality disorders, and substance use disorders (e.g., De Bellis et al. 2015, Kumari et al. 2014, Wang et al. 2014).”
From Child Sexual Abuse as a Unique Risk Factor for the Development of Psychopathology: The Compounded Convergence of Mechanisms (2021) · cites this paper as De Bellis et al. 2015
The Discussion (page not provided) links posterior brain differences to PTSD in maltreated youth and raises depression and substance use disorders as possible related outcomes requiring longitudinal study. It does not establish a developmental role for these differences in those later disorders, or address BPD, schizophrenia, or antisocial personality disorder as the claim states. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe neural findings agree with recent reports of anatomical differences in severely maltreated youths with posttraumatic stress disorder.
“Of interest, even though our sample reports low to moderate CT, our neural findings are consistent with recent findings of anatomical differences between severely maltreated youths with posttraumatic stress disorder (60).”
From Impact of Childhood Trauma on Executive Function in Adolescence—Mediating Functional Brain Networks and Prediction of High-Risk Drinking (2020) · cites this paper as [60]
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Self-citationProcessing of subliminal facial expressions of emotion: A behavioral and fMRI study
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Child Maltreatment and the Development of Posttraumatic Stress Disorder
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Cited by
Sorted by citations
The effects of childhood maltreatment on brain structure, function and connectivity
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Self-citation
- Authors
- De Bellis, M. D., Hooper, S. R., Chen, S. D., Provenzale, J. M., Boyd, B. D., Glessner, C. E., MacFall, J. R., Payne, M. E., Rybczynski, R., & Woolley, D. P.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-11
- Volume
- 27
- Issue
- 4pt2
- Pages
- 1555-1576
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC4815906
- OpenAlex
- W2463716776
- Cited by
- 75
- References
- 97
- Citations by year
- 2025: 4 · 2024: 14 · 2023: 7 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 1 · 2015: 1
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA012479, R01AA12479)
- National Institute of Mental Health (R01MH063407, R01- MH61744, K24MH71434, R01MH061744, R01MH63407, K24MH071434)
- National Institute on Drug Abuse (K24DA028773)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Safety Research › Child Welfare and Adoption
- Keywords
- child abuse, chronic posttraumatic stress disorder, resilience, gray matter volume, cerebellum, diffusion tensor imaging, pediatric trauma
- MeSH terms
- Adolescent, Cerebellum, Child, Child Abuse, Chronic Disease, Corpus Callosum, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Stress Disorders, Post-Traumatic, Cerebrum, Diffusion Tensor Imaging, Gray Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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