Cited by 61Proteoglycans and glycosaminoglycans researchNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice

Haunsø, Anders, Ibrahim, Merdol, Bartsch, Udo, Letiembre, Maryse, Celio, Marco R, Menoud, Pierre-Alain·2000·Brain Research

Abstract

Recently identified chondroitin sulphate proteoglycans in perineuronal nets include neurocan and phosphacan. However, the function and assembly of these components has yet to be resolved. In this study we show morphological alteration in Wisteria floribunda labelled nets around cortical interneurones both in tenascin-R knockout and tenascin-R/parvalbumin double knockout mice. This alteration reflects the loss of phosphacan and neurocan from cortical nets in mice deficient in tenascin-R. No effect on the membrane related cytoskeleton, as revealed by ankyrin(R), was observed in any of the mice. These results on mice lacking tenascin-R substantiate previously reported in vitro interactions between tenascin-R and phosphacan and neurocan.

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Crossref · 10.1016/s0006-8993(00)02173-9

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Authors
Haunsø, A., Ibrahim, M., Bartsch, U., Letiembre, M., Celio, M. R., & Menoud, P.-A.
Affiliations
  • University of Fribourg (CH)
  • Universität Hamburg (DE)
Corresponding author
Menoud, Pierre-Alain
Venue
Brain Research
Publisher
Elsevier BV
Published
2000-05
Volume
864
Issue
1
Pages
142-145
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2023467917
Cited by
61
References
20
Citations by year
2026: 1 · 2025: 5 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2013: 1 · 2012: 2
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
perineuronal nets, tenascin-R, parvalbumin, phosphacan, neurocan, chondroitin sulfate proteoglycans, cortical interneurons, ankyrin, membrane cytoskeleton, knockout mice
MeSH terms
Animals, Cerebral Cortex, Extracellular Matrix, Fluorescent Antibody Technique, Nerve Tissue Proteins, Neurons, Parvalbumins, Chondroitin Sulfate Proteoglycans, Mice, Knockout, Tenascin, Lectins, C-Type, Cell Size, Mice, Receptor-Like Protein Tyrosine Phosphatases, Class 5, Neurocan

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