Cited by 45Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Disturbance of perineuronal nets in the perilesional area after photothrombosis is not associated with neuronal death

Karetko-Sysa, Magdalena, Skangiel-Kramska, Jolanta, Nowicka, Dorota·2011·Experimental Neurology

Abstract

Perineuronal nets (PNNs) are a condensed form of extracellular matrix that covers the surface of a subset of neurons. Their presence limits neuronal plasticity and may protect neurons against harmful agents. Here we analyzed the relationship between spatiotemporal changes in PNN expression and cell death markers after focal cortical photothrombotic stroke in rats. We registered a substantial decrease in PNN density using Wisteria floribunda agglutinin staining and CAT-315 and brevican immunoreactivity; the decrease occurred not only in the lesion core but also in the perilesional and remote cortex as well as in homotopic contralateral cortical regions. Fluoro Jade C and TUNEL staining in perilesional and remote areas, however, showed a low density of dying cells. Our results suggest that the PNN reduction was not a result of cellular death and could be considered an attempt to create conditions favorable for synaptic remodeling.

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Crossref · 10.1016/j.expneurol.2011.05.022

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Authors
Karetko-Sysa, M., Skangiel-Kramska, J., & Nowicka, D.
Affiliations
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
Corresponding author
Nowicka, Dorota
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
2011-09
Volume
231
Issue
1
Pages
113-126
ISSN
0014-4886 (ISSN-L)
OpenAlex
W2045240514
Cited by
45
References
91
Citations by year
2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 9 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 2
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
perineuronal nets, photothrombotic stroke, perilesional cortex, neuronal cell death, extracellular matrix, brevican, Wisteria floribunda agglutinin, synaptic remodeling, neuroplasticity
MeSH terms
Animals, Cerebral Cortex, Disease Models, Animal, Extracellular Matrix, Male, Nerve Degeneration, Nerve Net, Neurons, Cell Death, Rats, Wistar, Brain Infarction, Intracranial Thrombosis, Rats

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