Distribution of parvalbumin-containing neurons and lectin-binding perineuronal nets in the rat basal forebrain
Abstract
In sections of rat brain treated for Wisteria floribunda agglutinin (WFA) labelling the occurrence of parvalbumin (PARV)-, calbindin (CALB)- or choline acetyltransferase (ChAT) immunoreactivity was analyzed in the basal forebrain using dual-peroxidase and double-fluorescence methods. Only PARV-immunoreactive (-ir) neurons were surrounded by WFA-labelled, i.e. N-acetylgalactosamine-containing, perineuronal lattice-like structures known as perineuronal nets. The distribution of these nets and PARV-ir cells in the rat basal forebrain was documented to obtain detailed data on their co-existence. A remarkable diversity in distribution of both markers was observed, as PARV-ir neurons are only associated with nets in the medial septal nucleus, the nuclei of the diagonal band and the magnocellular preoptic nucleus, but not in the ventral pallidum or the substantia innominata/nucleus basalis complex. These differences in the neuronal microenvironment may reflect system-related specializations of neurons within the basal forebrain nuclei.
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A large population of WFA-labeled PNNs ensheaths fast-firing inhibitory interneurons expressing parvalbumin and Kv3.1b.
“Several studies in rodent, human and non-human primates have shown that a large population of WFA-labeled PNNs ensheaths fast-firing inhibitory interneurons expressing the calcium binding protein parvalbumin (PVB) and Kv3.1b, a subunit of voltage gated potassium channels typically expressed in fast-firing neurons (Brauer et al., 1993; Hartig et al., 1995; Morris and Henderson, 2000; Pantazopoulos”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Brauer et al., 1993
PNN-bearing neurons are predominantly GABAergic, including but not restricted to those expressing parvalbumin and somatostatin.
“As discussed, these are predominantly represented by GABAergic neurons, including, but not restricted to, those expressing PVB and somatostatin (Adams et al., 2001; Brauer et al., 1993; Bruckner et al., 1993; Hartig et al., 1995; Hartig et al., 2001; Haunso et al., 1999; Morris and Henderson, 2000; Pantazopoulos et al., 2006; Wintergerst et al., 1996) (Pantazopoulos et al., unpublished”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Brauer et al., 1993
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- Authors
- Brauer, K., Ha¨rtig, W., Bigl, V., & Bru¨ckner, G.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Brauer, Kurt
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1993-12
- Volume
- 631
- Issue
- 1
- Pages
- 167-170
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2012993742
- Cited by
- 75
- References
- 19
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 1 · 2020: 1 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- parvalbumin, perineuronal nets, basal forebrain, Wisteria floribunda agglutinin, calbindin, choline acetyltransferase, N-acetylgalactosamine, medial septum, diagonal band of Brodmann, magnocellular preoptic nucleus, substantia innominata, nucleus basalis of Meynert, neuronal microenvironment
- MeSH terms
- Animals, Immunologic Techniques, Nerve Net, Neurons, Parvalbumins, Tissue Distribution, Prosencephalon, Rats, Wistar, Lectins, Rats
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