The DOI matches its Crossref record; 107 of the 111 references it cites were found in a registry or an index.
Immunobiology of endometriosis
Open accessAbstract
Objective To provide a review of the humoral and cellular immunology of endometriosis and to discuss the rationale for future approaches to diagnosis and treatment.Design Literature survey.Result(s) Defective immunosurveillance in women who are destined to develop endometriosis may allow for the survival of ectopic endometrial tissue. The evidence includes endometrial cell resistance to apoptosis, perhaps through the secretion of proteins that interfere with implant recognition and/or FasL expression by stromal cells, inducing apoptosis of Fas-bearing immune cells. Although the immune response may be defective, aspects of it clearly are enhanced in endometriosis, as is seen by the generalized polyclonal B-cell autoimmune activation and secretion of immune proteins. Several cytokines, chemokines, and growth factors (including vascular growth factors) are increased in women with endometriosis.Conclusion(s) A complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants. Proinflammatory proteins from endometriotic lesions and associated immune cells contribute to the enhanced inflammatory reaction associated with endometriosis that subserves the survival of these lesions instead of leading to their demise.
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“Immune phenomena are important for explaining the possible pathomechanisms of endometriosis foci, as studies indicate altered humoral and cellular immunity [56].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [56]
Citations
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Metadata
- Authors
- Lebovic, D. I., Mueller, M. D., & Taylor, R. N.
- Affiliations
- University of Michigan (US)
- University of California, San Francisco (US)
- Corresponding author
- Taylor, Robert N
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 75
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2017027476
- Cited by
- 857
- References
- 111
- Citations by year
- 2026: 19 · 2025: 34 · 2024: 25 · 2023: 32 · 2022: 30 · 2021: 36 · 2020: 28 · 2019: 26 · 2018: 23 · 2017: 25 · 2016: 34 · 2015: 40 · 2014: 41 · 2013: 39 · 2012: 42
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f32hd008517-01)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD037321, F32HD08517, U54 HD37321)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, immune surveillance, apoptosis resistance, Fas ligand, B cell activation, cytokines, chemokines, growth factors, vascular growth factors, inflammation
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Middle Aged, Pregnancy
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