Cited by 264Endometriosis Research and TreatmentReproductive System and PregnancyDiagnosis and treatment of tuberculosis

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Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis

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Rana, Nasir, Braun, Donald P., House, Robert, Gebel, Howard, Rotman, Carlos, Dmowski, W. Paul·1996·Fertility and Sterility

DOI 10.1016/s0015-0282(16)58262-4

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Abstract

Objective To evaluate basal (constitutive) and stimulated synthesis of tumor necrosis factor alpha (TNF alpha), interleukin (IL)-8, IL-10 by peritoneal macrophages (PM) in women with endometriosis.Design Peritoneal macrophages were cultured in the presence or absence of lipopolysaccharide (LPS) for 24 hours. Peritoneal fluids (PF) and PM supernatants were assayed for cytokines using ELISA.Setting Institute for the Study and Treatment of Endometriosis and university-based research laboratories.Subjects Fertile controls undergoing tubal ligation (n = 8) and women with endometriosis (n = 17).Intervention Peritoneal fluid samples were obtained at the time of diagnostic laparoscopy (endometriosis group) or laparoscopy for tubal ligation; both were performed in the midluteal phase of the cycle.Results Both basal and LPS stimulated production of TNF alpha, IL-8, and IL-10 by the PM were elevated significantly in women with endometriosis as compared with the fertile controls.Conclusions This study demonstrated that cytokines TNF alpha, IL-8, and IL-10 are synthesized at greater than normal levels by basal and stimulated PM from women with endometriosis. The levels of TNF alpha and IL-8 correlated with the levels in the PF, suggesting that PM are the principal source of these cytokines in the PF.

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Background
Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain
Akoum, A., Al-Akoum, M., Lemay, A., Maheux, R., & Leboeuf, M. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.019 · Cited by 78
Macrophage migration inhibitory factor expression in the intrauterine endometrium of women with endometriosis varies with disease stage, infertility status, and pelvic pain
Akoum, A., Metz, C. N., Al-Akoum, M., & Kats, R. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.073 · Cited by 79
Dioxin-like PCBs and Endometriosis
Bruner‐Tran, K. L., & Osteen, K. G. (2010) · Systems Biology in Reproductive Medicine · doi:10.3109/19396360903381023 · Cited by 77
“1994] and an enhanced activation state of monocytes and peritoneal macrophages [Braun et al. 1996; Rana et al. 1996; Zeller et al. 1987].”
Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8
Mülayim, N., Savlu, A., Guzeloglu‐Kayisli, O., Kayisli, U. A., & Arici, A. M. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.11.015 · Cited by 78
The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment
Qin, R., Tian, G., Liu, J., & Cao, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1069557 · Cited by 77
“Other studies have shown that macrophages can promote the release of inflammatory mediators under lipopolysaccharide stimulation, thereby promoting the inflammatory infiltration, proliferation and angiogenesis observed in endometriosis (Rana et al., 1996; Jeljeli et al., 2020).”
Background
MAP kinases and the inflammatory signaling cascade as targets for the treatment of endometriosis?
Santulli, P., Marcellin, L., Tosti, C., Chouzenoux, S., Cerles, O., Borghese, B., Batteux, F., & Chapron, C. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1090974 · Cited by 75
“Peritoneal fluids of women with endometriosis contain a large number of activated macrophages and exhibit pronounced differences in their cytokine/chemokine profiles [24].”
Background
Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis
Akoum, A., Jolicoeur, C., & Boucher, A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6348 · Cited by 85
Pathogenesis of Endometriosis
Witz, C. A. (2002) · Gynecologic and Obstetric Investigation · doi:10.1159/000049425 · Cited by 73
Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis
Ho, H., Wu, M., Chen, S., Chao, K., Chen, C., & Yang, Y. (1997) · Human Reproduction · doi:10.1093/humrep/12.12.2810 · Cited by 73
“Previously we and others have reported raised concentrations of cytokines from immune cells — most likely from activated macrophages — in the peritoneal fluid of women with endometriosis (Oosterlynck et al., 1994; Sharpe-Timms et al., 1994; Keenan et al., 1995; Skrzypczak et al., 1995; Ho et al., 1996; Overton et al.,…”
Background
Polymorphism in Vitamin D-Binding Protein as a Genetic Risk Factor in the Pathogenesis of Endometriosis
Faserl, K., Golderer, G., Kremser, L., Lindner, H. H., Sarg, B., Wildt, L., & Seeber, B. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1532 · Cited by 71
Tumour necrosis factor-α up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-κB
Cao, W. G., Morin, M., Sengers, V., Metz, C. N., Roger, T., Maheux, R., & Akoum, A. (2005) · Human Reproduction · doi:10.1093/humrep/dei315 · Cited by 68
“Elevated concentrations of TNF-α were found in the peritoneal fluid of women with endometriosis (Rana et al., 1996; Barcz et al., 2000; Iwabe et al., 2000; Bedaiwy et al., 2002; Bullimore, 2003; Darai et al., 2003).”
Background
Estradiol and Interleukin-1β Exert a Synergistic Stimulatory Effect on the Expression of the Chemokine Regulated upon Activation, Normal T Cell Expressed, and Secreted in Endometriotic Cells
Akoum, A., Lemay, A., & Maheux, R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020106 · Cited by 67
Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin
García-Velasco, J. A., & Arici, A. M. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00223-x · Cited by 65
Endometriosis is sustained by tumour necrosis factor-α
Bullimore, D. W. (2002) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00336-5 · Cited by 63
Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70
Khan, K. N., Kitajima, M., Imamura, T., Hiraki, K., Fujishita, A., Sekine, I., Ishimaru, T., & Masuzaki, H. (2008) · Human Reproduction · doi:10.1093/humrep/den195 · Cited by 62
Interleukin-10 gene promoter polymorphisms and their protein production in peritoneal fluid in patients with endometriosis
Zhang, X., Hei�, P., Deng, L., & Lin, J. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal106 · Cited by 62
“Interestingly, some authors have reported that protein levels of IL-10 in PF are significantly increased in patients with endometriosis compared with controls (Punnonen et al., 1996; Ho et al., 1997b), although this has not been found in all studies (Rana et al., 1996; McLaren et al., 1997).”
BackgroundResult
Pathophysiology of Endometriosis-Associated Infertility
Burns, W. N., & Schenken, R. S. (1999) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-199909000-00014 · Cited by 61
Premenstrual and Menstrual Changes in the Macaque and Human Endometrium: Relevance to Endometriosis
BRENNER, R. M., NAYAK, N. R., SLAYDEN, O. D., CRITCHLEY, H. O. D., & KELLY, R. W. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02766.x · Cited by 59
Endometriosis-Related Chronic Pelvic Pain
Song, S. Y., Jung, Y. W., Shin, W., Park, M., Lee, G. W., Jeong, S., An, S., Kim, K.-M., Ko, Y. B., Lee, K. H., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11102868 · Cited by 75
Alpinetin ameliorates inflammatory response in LPS-induced endometritis in mice
Liang, Y., Shen, T., Qi, M., Han, G., Zhang, Y., Liang, J., & Zhu, D. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.07.010 · Cited by 58
Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: A prospective, double-blind, randomized, placebo-controlled study
Alborzi, S., Ghotbi, S. H., Parsanezhad, M. E., Dehbashi, S., Alborzi, S., & Alborzi, M. (2007) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2006.06.024 · Cited by 56
Future Perspectives in the Medical Treatment of Endometriosis
Ferrero, S., Abbamonte, L. H., Anserini, P., Remorgida, V., & Ragni, N. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000189153.87365.dc · Cited by 56
Recent advances in the understanding of endometriosis: the role of inflammatory mediators in disease pathogenesis and treatment
Nothnick, W. B., & Alali, Z. (2016) · F1000Research · doi:10.12688/f1000research.7504.1 · Cited by 55
Impact of endometriosis on surgical outcomes and complications of total laparoscopic hysterectomy
Uccella, S., Marconi, N., Casarin, J., Ceccaroni, M., Boni, L., Sturla, D., Serati, M., Carollo, S., Alluvion, C. P., & Ghezzi, F. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-016-4115-9 · Cited by 54
Elevated levels of macrophage migration inhibitory factor in the peripheral blood of women with endometriosis
Morin, M., Bellehumeur, C., Therriault, M., Metz, C. N., Maheux, R., & Akoum, A. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.10.039 · Cited by 53
Increase in the Production of Interleukin‐6, Interleukin‐10, and Interleukin‐12 by Lipopolysaccharide‐Stimulated Peritoneal Macrophages from Women with Endometriosis
Wu, M., Ho, H., Chen, S., Chao, K., Chen, C., & Yang, Y. (1999) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1999.tb00082.x · Cited by 52

Authors: Rana, N., Braun, D. P., House, R., Gebel, H., Rotman, C., & Dmowski, W. P.
Affiliations: Rush University Medical Center (US)
ORCID: Gebel, Howard
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 1996-05
Volume: 65
Issue: 5
Pages: 925-930
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/s0015-0282(16)58262-4
OpenAlex: W98713221
Cited by: 264
References: 27
Citations by year: 2026: 2 · 2025: 8 · 2024: 12 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 9
FWCI: 11.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 9522 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca058922-03)
National Cancer Institute (CA 58922)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
Keywords: endometriosis, peritoneal macrophages, cytokine production, TNF-α, interleukin-8, IL-10, lipopolysaccharide stimulation, peritoneal fluid
MeSH terms: Ascitic Fluid, Cells, Cultured, Endometriosis, Female, Humans, Lipopolysaccharides, Tumor Necrosis Factor-alpha, Cytokines, Interleukin-8, Interleukin-10, Macrophages, Peritoneal

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Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis

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