Cited by 1,142Bone health and osteoporosis researchElasticity and Material ModelingBone fractures and treatments

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Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue

Bayraktar, Harun H., Morgan, Elise F., Niebur, Glen L., Morris, Grayson E., Wong, Eric K., Keaveny, Tony M.·2004·Journal of Biomechanics

DOI 10.1016/s0021-9290(03)00257-4

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Abstract

The ability to determine trabecular bone tissue elastic and failure properties has biological and clinical importance. To date, trabecular tissue yield strains remain unknown due to experimental difficulties, and elastic moduli studies have reported controversial results. We hypothesized that the elastic and tensile and compressive yield properties of trabecular tissue are similar to those of cortical tissue. Effective tissue modulus and yield strains were calibrated for cadaveric human femoral neck specimens taken from 11 donors, using a combination of apparent-level mechanical testing and specimen-specific, high-resolution, nonlinear finite element modeling. The trabecular tissue properties were then compared to measured elastic modulus and tensile yield strain of human femoral diaphyseal cortical bone specimens obtained from a similar cohort of 34 donors. Cortical tissue properties were obtained by statistically eliminating the effects of vascular porosity. Results indicated that mean elastic modulus was 10% lower (p<0.05) for the trabecular tissue (18.0+/-2.8 GPa) than for the cortical tissue (19.9+/-1.8 GPa), and the 0.2% offset tensile yield strain was 15% lower for the trabecular tissue (0.62+/-0.04% vs. 0.73+/-0.05%, p<0.001). The tensile-compressive yield strength asymmetry for the trabecular tissue, 0.62 on average, was similar to values reported in the literature for cortical bone. We conclude that while the elastic modulus and yield strains for trabecular tissue are just slightly lower than those of cortical tissue, because of the cumulative effect of these differences, tissue strength is about 25% greater for cortical bone.

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“73% tensile (Bayraktar et al., 2004), εmax is the maximum strain recorded in the femur.”
BackgroundInfluential
A new evolutionary optimization method for osteoporotic bone augmentation
Artiles, M. E. S., & Venetsanos, D. T. (2017) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2017.1291805 · Cited by 8
“To this end, the maximum (εmax) and minimum (εmin) element principal strains should be within the allowable yield strain values of 0.73% in tension and −1.04% in compression (Bayraktar et al. 2004).”
BackgroundInfluential
Simulated lesions representative of metastatic disease predict proximal femur failure strength more accurately than idealized lesions
Johnson, J. E., Brouillette, M. J., Permeswaran, P., Miller, B. J., & Goetz, J. E. (2020) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2020.109825 · Cited by 8
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“In addition, its yield strength (210 ± 8.878 MPa) [25] far exceeds the yield strength of human bone (133.6 ± 34.1 MPa) [26], which can meet the needs of daily human movement load-bearing.”
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In Silico clinical trial to predict the efficacy of hip protectors for preventing hip fractures
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Finite element and microstructural analyses indicate that pteraspid heterostracan oral plate microstructure was adapted to a mechanical function
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“Compression is mainly withstood by bone, which is stronger under compressive stress than under tension (Bayraktar et al., 2004; Beaupied et al., 2007; Keaveny et al., 1994).”
Validation of a Finite Element Human Model for Prediction of Rib Fractures
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Background
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BackgroundResult
Retracted
Performance of the resurfaced hip. Part 2: The influence of prosthesis stem design on remodelling and fracture of the femoral neck
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BackgroundMethod
Finite Element Model-Computed Mechanical Behavior of Femurs with Metastatic Disease Varies Between Physiologic and Idealized Loading Simulations
Johnson, J. E., Brouillette, M. J., Miller, B. J., & Goetz, J. E. (2023) · Biomedical Engineering and Computational Biology · doi:10.1177/11795972231166240 · Cited by 6
Biomechanical analysis of All-on-4 implant supported framework using different materials across various clinical practice
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“When the CL is 12 mm, The maximum jawbone stress in the Ti group surpasses the cortical bone yield strength of 104 MPa reported by Bayraktar, which is considered to potentially lead to bone fatigue and thereby increase the risk of fracture [33, 36].”

Authors: Bayraktar, H. H., Morgan, E. F., Niebur, G. L., Morris, G. E., Wong, E. K., & Keaveny, T. M.
Affiliations: University of California, Berkeley (US)
University of Notre Dame (US)
Corresponding author: Bayraktar, Harun H.
ORCID: Morgan, Elise F.
Niebur, Glen L.
Keaveny, Tony M.
Venue: Journal of Biomechanics
Publisher: Elsevier BV
Published: 2004-01
Volume: 37
Issue: 1
Pages: 27-35
ISSN: 0021-9290 (ISSN-L)
DOI: 10.1016/s0021-9290(03)00257-4
OpenAlex: W2089968363
Cited by: 1,142
References: 36
Citations by year: 2026: 60 · 2025: 62 · 2024: 68 · 2023: 51 · 2022: 55 · 2021: 74 · 2020: 90 · 2019: 75 · 2018: 67 · 2017: 56 · 2016: 68 · 2015: 59 · 2014: 62 · 2013: 50 · 2012: 49
FWCI: 13.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Biomechanics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
University of California, San Francisco
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-43784, R01AR043784, AR41481)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
Keywords: trabecular bone, cortical bone, femoral neck, elastic modulus, yield strain, tensile yield strength, compressive yield strength, finite element analysis
MeSH terms: Aged, Aged, 80 and over, Cadaver, Computer Simulation, Elasticity, Femur Head, Humans, Male, Middle Aged, Models, Biological, Sensitivity and Specificity, Statistics as Topic, Stress, Mechanical, Tensile Strength, Reproducibility of Results, Weight-Bearing, Compressive Strength, In Vitro Techniques

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Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue

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