Cited by 83Tryptophan and brain disordersStress Responses and CortisolVagus Nerve Stimulation Research

Mild acute inflammatory stimulation induces transient negative mood

Open access
Strike, Philip C., Wardle, Jane, Steptoe, Andrew·2004·Journal of Psychosomatic Research

Abstract

Objective This study aims to assess the mood changes induced by mild acute inflammatory stimulation (typhoid vaccination). Methods Using a double blind study design, 26 healthy volunteers underwent baseline assessments of mood, financial strain and work stress and were randomised to injection of Salmonella typhi vaccine or placebo injection. Mood, symptoms and body temperature was assessed by a modified version of the Profile of Mood States at 1, 2, 3, 4, 6 and 8 h post injection. Results Typhoid vaccination induces no increases in physical symptoms or temperature. Mood improved over the day in the placebo but not in the vaccine condition. Negative changes in mood following injection were correlated with chronic stress (financial strain) in the vaccination condition (r=-.65, P<.025). Conclusion A mild acute inflammatory stimulus induces transient negative mood, and responses were modulated by chronic stress. Implications for depressed mood in physical illness are discussed.

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Crossref · 10.1016/s0022-3999(03)00569-5

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  • Typhoid vaccination elicits significant increases in negative mood, confusion, and fatigue, and these effects are mediated by changes in IL-6.

    “typhoid vaccination, which is a relatively mild inflammatory challenge, elicits significant increases in negative mood, confusion, and fatigue, and these effects are mediated by changes in IL-6”

    From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Strike, Wardle, & Steptoe, 2004

    The Results (Mood responses to vaccination; page unavailable) report a significant difference in overall mood between vaccine and placebo groups during the first three hours. The Methods (Statistical analysis; page unavailable) say confusion and fatigue contributed to the combined mood score, but the paper does not report significant increases in those symptoms individually. The Discussion (page unavailable) explicitly says cytokines were not measured, so IL-6 mediation was not established. (LLM, conf=0.90)

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2 of the 40 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. [7]Kop WJ Gottdiener JS Tangen CM Fried LP McBurnie MA Walston J Newman A Hirsch C Tracy RP Inflammation and coagulation factors in Persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia Am J Cardiol 89 4 2002 419 424 15 Feb 11835923
  2. [31]Kharbanda RK Walton B Allen M Klein N Hingorani AD MacAllister RJ VAllance P Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin Circulation 105 22 2002 2600 2604 4 Jun 12045164

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Authors
Strike, P. C., Wardle, J., & Steptoe, A.
Affiliations
University College London (GB)
Corresponding author
Strike, Philip C.
Venue
Journal of Psychosomatic Research
Publisher
Elsevier BV
Published
2004-08
Volume
57
Issue
2
Pages
189-194
ISSN
0022-3999 (ISSN-L)
OpenAlex
W1997103984
Cited by
83
References
40
Citations by year
2026: 4 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 10 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 4
FWCI
1.48
Type
journal article
Language
en
Open access
Locations
  • Journal of Psychosomatic Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • British Heart Foundation
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
mood, acute inflammation, typhoid vaccination, negative mood, chronic stress, financial stress, occupational stress, body temperature, Profile of Mood States
MeSH terms
Acute Disease, Adult, Blood Pressure, Double-Blind Method, Female, Humans, Injections, Male, Salmonella typhi, Typhoid Fever, Typhoid-Paratyphoid Vaccines, Mood Disorders

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