Cited by 2,120Alzheimer's disease research and treatmentsTrace Elements in HealthDementia and Cognitive Impairment Research

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Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M.A, Robertson, J.D, Teesdale, W.J, Campbell, J.L, Markesbery, W.R·1998·Journal of the Neurological Sciences

DOI 10.1016/s0022-510x(98)00092-6

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Abstract

Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil (P<0.05). Copper was significantly elevated (P<0.05) in the rim of SP compared with AD neuropil. Comparison of AD and control neuropil revealed a significant (P<0.05) elevation of Zn in AD subjects. The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.

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“On the other hand, serum levels of Cu2+ were shown to be increased in AD patients compared to control subjects [172].”
BackgroundInfluential
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Authors: Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R.
Affiliations: University of Kentucky (US)
University of Guelph (CA)
ORCID: Lovell, M.A
Robertson, J.D
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 1998-06
Volume: 158
Issue: 1
Pages: 47-52
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/s0022-510x(98)00092-6
OpenAlex: W2083500052
Cited by: 2,120
References: 72
Citations by year: 2026: 38 · 2025: 52 · 2024: 69 · 2023: 82 · 2022: 100 · 2021: 92 · 2020: 95 · 2019: 103 · 2018: 80 · 2017: 94 · 2016: 87 · 2015: 82 · 2014: 89 · 2013: 96 · 2012: 116
FWCI: 18.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (2-PO1-AG05119, P01AG005119, 5-P50 AG0514)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, amyloid plaques, copper, iron, zinc, trace elements, amygdala, amyloid-beta aggregation, neuropil
MeSH terms: Alzheimer Disease, Amygdala, Copper, Humans, Iron, Spectrometry, X-Ray Emission, Zinc, Neuropil, Biotinylation, Plaque, Amyloid

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Copper, iron and zinc in Alzheimer's disease senile plaques

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