Age-Related Macular Degeneration: A High-Resolution Genome Scan for Susceptibility Loci in a Population Enriched for Late-Stage Disease
Open accessAbstract
Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the central region of the retina. AMD is clinically heterogeneous, leading to geographic atrophy (GA) and/or choroidal neovascularization (CNV) at advanced stages. Considerable data exists in support of a genetic predisposition for AMD. Recent linkage studies have provided evidence in favor of several AMD susceptibility loci. We have performed a high-resolution (5-cM) genome scan of 412 affected relative pairs that were enriched for late-stage disease (GA and/or CNV). Nonparametric linkage analysis was performed using two different diagnostic criteria and also by dividing the affected individuals according to GA or CNV phenotype. Our results demonstrate evidence of linkage in regions that were suggested in at least one previous study at chromosomes 1q (236-240 cM in the Marshfield genetic map), 5p (40-50 cM), and 9q (111 cM). Multipoint analysis of affected relatives with CNV provided evidence of additional susceptibility loci on chromosomes 2p (10 cM) and 22q (25 cM). A recently identified Gln5345Arg change in HEMICENTIN-1 on chromosome 1q25 was not detected in 274 affected members in the restricted group with AMD, 346 additional patients with AMD, and 237 unaffected controls. Our results consolidate the chromosomal locations of several AMD susceptibility loci and, together with previous reports, should facilitate the search for disease-associated sequence variants.
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These linkage studies provided more modest evidence for linkage on many other chromosomes, including a region on chromosome 22 near TIMP3.
“In addition, these studies provided more modest evidence for linkage on many other chromosomes (2, 77, 104, 137, 160), including a region on chromosome 22 near TIMP3, the gene mutated in Sorsby fundus dystrophy (158) (Figure 4).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [2]
Several genome-wide linkage scans for AMD have found suggestive linkage on chromosome 1q.
“Several genome-wide linkage scans for AMD including ours (unpublished data) have found suggestive linkage on chromosome 1q [9–15].”
From CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD (2005) · cites this paper as [14]
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Cites
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341 · see citing works
Merlin—rapid analysis of dense genetic maps using sparse gene flow trees
Abecasis, G. R., Cherny, S. S., Cookson, W., & Cardon, L. R. (2001) · Nature Genetics · doi:10.1038/ng786 · Cited by 3,323 · see citing works
Self-citationBird, A. C., Bressler, N. M., Bressler, S. B., Chisholm, I. H., Coscas, G., Davis, M. D., de Jong, P. T. V. M., Klaver, C. C. W., Klein, B. E. K., Klein, R., et al. (1995) · Survey of Ophthalmology · doi:10.1016/s0039-6257(05)80092-x · Cited by 1,926 · see citing works
Prevalence of age-related maculopathy
Klein, R., Klein, B. E. K., & Linton, K. L. P. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31871-8 · Cited by 1,845 · see citing works
Weir, B. S. (1990) · Cited by 1,340 · see citing works
Hageman, G. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00010-6 · Cited by 1,265 · see citing works
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222551899 · Cited by 1,208 · see citing works
The Five-year Incidence and Progression of Age-related Maculopathy
Klein, R., Klein, R., Jensen, S. C., & Meuer, S. M. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30368-6 · Cited by 1,148 · see citing works
Risk factors for age-related macular degeneration
Smith, W., Assink, J., Klein, R., Mitchell, P., Klaver, C. C. W., Klein, B. E. K., Hofman, A., Jensen, S., Wang, J. J., & de Jong, P. T. V. M. (2001) · Ophthalmology · doi:10.1016/s0161-6420(00)00580-7 · Cited by 1,071 · see citing works
Allele-sharing models: LOD scores and accurate linkage tests.
Kong, A., & Cox, N. (1997) · American Journal of Human Genetics · doi:10.1086/301592 · Cited by 1,036 · see citing works
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959 · see citing works
Online Mendelian Inheritance in Man 'OMIM'.
Amladi, S. (2007) · PubMed · Cited by 871 · see citing works
Linkage strategies for genetically complex traits. II. The power of affected relative pairs.
RISCH, N. J. (1990) · PubMed · Cited by 868 · see citing works
The Prevalence of Age-related Maculopathy in the Rotterdam Study
Vingerling, J. R., Dielemans, I., Hofman, A., Grobbee, D. E., Hijmering, M., Kramer, C. F. L., & de Jong, P. T. V. M. (1995) · Ophthalmology · doi:10.1016/s0161-6420(95)31034-2 · Cited by 815 · see citing works
Age-related macular degeneration
Bressler, N. M., Bressler, S. B., & Fine, S. L. (1988) · Survey of Ophthalmology · doi:10.1016/0039-6257(88)90052-5 · Cited by 710 · see citing works
Weber, B. H. F., Vogt, G., Pruett, R. C., Stöhr, H., & Felbor, U. (1994) · Nature Genetics · doi:10.1038/ng1294-352 · Cited by 656 · see citing works
Oxidative damage and protection of the RPE
Cai, J., Nelson, K. C., Wu, M., Sternberg, P., & Jones, D. P. (2000) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(99)00009-9 · Cited by 628 · see citing works
Johnson, L. V., Leitner, W. P., Rivest, A. J., Staples, M. K., Radeke, M. J., & Anderson, D. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192203399 · Cited by 447 · see citing works
Genetics and the Specificity of the Aging Process
Hekimi, S., & Guarente, L. (2003) · Science · doi:10.1126/science.1082358 · Cited by 434 · see citing works
A class of tests for linkage using affected pedigree members.
Whittemore, A., & Halpern, J. (1994) · Biometrics · doi:10.2307/2533202 · Cited by 410 · see citing works
GRR: graphical representation of relationship errors
Abecasis, G. R., Cherny, S. S., Cookson, W., & Cardon, L. R. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.8.742 · Cited by 383 · see citing works
Self-citationFamilial aggregation of age-related maculopathy
SEDDON, J. M., AJANI, U. A., & MITCHELL, B. D. (1997) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)71036-0 · Cited by 350 · see citing works
Risk Factors for Age-related Macular Degeneration
Evans, J. R. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00023-9 · Cited by 337 · see citing works
Genetic Risk of Age-related Maculopathy: Population-Based Familial Aggregation Study
Klaver, C. C. W. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.12.1646 · Cited by 323 · see citing works
Histopathology of Age-Related Macular Degeneration
Lim, J. I. (2007) · CRC Press eBooks · doi:10.3109/9781420019865-6 · Cited by 310 · see citing works
Familial Aggregation of Age-related Maculopathy
Seddon, J. M., Ajani, U. A., & Mitchell, B. (1998) · Retina · doi:10.1097/00006982-199818020-00028 · Cited by 303 · see citing works
Further Evidence for an Association of ABCR Alleles with Age-Related Macular Degeneration
Allikmets, R. (2000) · The American Journal of Human Genetics · doi:10.1086/303018 · Cited by 303 · see citing works
Improved Inference of Relationship for Pairs of Individuals
Epstein, M. P., Duren, W. L., & Boehnke, M. (2000) · The American Journal of Human Genetics · doi:10.1016/s0002-9297(07)62952-8 · Cited by 272 · see citing works
Malek, G., Li, C.-M., Guidry, C., Medeiros, N. E., & Curcio, C. A. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63836-9 · Cited by 270 · see citing works
Age-related Macular Degeneration: Clinical Features in a Large Family and Linkage to Chromosome 1q
Klein, M. L. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.8.1082 · Cited by 252 · see citing works
Seddon, J. M., Santangelo, S. L., Book, K., Chong, S., & Cote, J. (2003) · The American Journal of Human Genetics · doi:10.1086/378505 · Cited by 208 · see citing works
Age-related macular degeneration–a genome scan in extended families
Majewski, J., Schultz, D. W., Weleber, R. G., Schain, M. B., Edwards, A. O., Matise, T. C., Acott, T. S., Ott, J., & Klein, M. L. (2003) · The American Journal of Human Genetics · doi:10.1086/377701 · Cited by 201 · see citing works
Schultz, D. W., Klein, M. L., Humpert, A. J., Luzier, C. W., Persun, V., Schain, M. B., Mahan, A. E., Runckel, C., Cassera, M. A., Vittal, V., et al. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg348 · Cited by 191 · see citing works
Risk Factors of Age-related Maculopathy in a Population 70 Years of Age or Older
Hirvelä, H., Luukinen, H., Läärä, E., & Laatikainen, L. (1996) · Ophthalmology · doi:10.1016/s0161-6420(96)30593-9 · Cited by 183 · see citing works
A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy
Schmidt, S., Klaver, C. C. W., Saunders, A. M., Postel, E. A., De La Paz, M. A., Agarwal, A., Small, K. W., Udar, N., Ong, J. M., Chalukya, M. V., et al. (2002) · Ophthalmic Genetics · doi:10.1076/opge.23.4.209.13883 · Cited by 149 · see citing works
The impact of genotyping error on family-based analysis of quantitative traits
Abecasis, G. R., Cherny, S. S., & Cardon, L. R. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200594 · Cited by 142 · see citing works
Self-citationWeeks, D. E., Conley, Y. P., Tsai, H.-J., Mah, T. S., Rosenfeld, P. J., Paul, T. O., Eller, A. W., Morse, L. S., Dailey, J. P., Ferrell, R. E., et al. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01214-4 · Cited by 140 · see citing works
A full genome scan for age-related maculopathy
Weeks, D. E. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1329 · Cited by 137 · see citing works
Microarray analysis of gene expression in the aging human retina.
Yoshida, S., Yashar, B. M., Hiriyanna, S., & Swaroop, A. (2002) · PubMed · Cited by 114 · see citing works
Self-citationSchick, J. H., Iyengar, S. K., Klein, B. E. K., Klein, R., Reading, K., Liptak, R., Millard, C., Lee, K. E., Tomany, S. C., Moore, E., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375500 · Cited by 110 · see citing works
Histopathology of age-related macular degeneration
Kang, S. J., & Grossniklaus, H. E. (2012) · CRC Press eBooks · doi:10.1201/b14548-2 · Cited by 99 · see citing works
Genetics of Age-Related Macular Degeneration
Lim, J. I. (2007) · CRC Press eBooks · doi:10.3109/9781420019865-8 · Cited by 96 · see citing works
Liesegang, T. J. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01493-9 · Cited by 94 · see citing works
Towards an understanding of age-related macular disease
Bird, A. C. (2003) · Eye · doi:10.1038/sj.eye.6700562 · Cited by 92 · see citing works
Molecular genetics of age-related macular degeneration
Stone, E. M. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.20.2285 · Cited by 79 · see citing works
Linkage Thresholds for Two-stage Genome Scans
Kruglyak, L., & Daly, M. J. (1998) · The American Journal of Human Genetics · doi:10.1086/301792 · Cited by 47 · see citing works
A Survey of Affected-Sibship Statistics for Nonparametric Linkage Analysis
Sengul, H., Weeks, D. E., & Feingold, E. (2001) · The American Journal of Human Genetics · doi:10.1086/321264 · Cited by 42 · see citing works
The Map Problem: A Comparison of Genetic and Sequence-Based Physical Maps
DeWan, A. T., Parrado, A., Matise, T. C., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/324774 · Cited by 32 · see citing works
Genetics of Age-related Macular Degeneration
DeAngelis, M. M., & Ji, F. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-0016-7.50146-6 · Cited by 23 · see citing works
Multipoint and single point non‐parametric linkage analysis with imperfect data
Sullivan, P. F., Neale, B. M., Neale, M. C., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20069 · Cited by 17 · see citing works
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Cited by
Sorted by citations
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works
Complement factor H polymorphism and age-related macular degeneration
Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works
Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961 · see citing works
Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3448 · Cited by 1,544 · see citing works
Self-citationRivera, A., Fisher, S. A., Fritsche, L. G., Keilhauer, C. N., Lichtner, P., Meitinger, T., & Weber, B. H. F. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi353 · Cited by 788 · see citing works
Chen, W., Stambolian, D., Edwards, A. O., Branham, K. E., Othman, M., Jakobsdottir, J., Tosakulwong, N., Pericak-Vance, M. A., Campochiaro, P. A., Klein, M. L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912702107 · Cited by 506 · see citing works
Self-citationSusceptibility genes for age-related maculopathy on chromosome 10q26
Jakobsdottir, J., Conley, Y. P., Weeks, D. E., Mah, T. S., Ferrell, R. E., & Gorin, M. B. (2005) · The American Journal of Human Genetics · doi:10.1086/444437 · Cited by 470 · see citing works
Kanda, A., Chen, W., Othman, M., Branham, K. E. H., Brooks, M., Khanna, R., He, S., Lyons, R., Abecasis, G. R., & Swaroop, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703933104 · Cited by 441 · see citing works
Self-citationZareparsi, S., Branham, K. E. H., Li, M., Shah, S., Klein, R. J., Ott, J., Hoh, J., Abecasis, G. R., & Swaroop, A. (2005) · The American Journal of Human Genetics · doi:10.1086/431426 · Cited by 371 · see citing works
Self-citationLi, M., Atmaca-Sonmez, P., Othman, M., Branham, K. E. H., Khanna, R., Wade, M. S., Li, Y., Liang, L., Zareparsi, S., Swaroop, A., et al. (2006) · Nature Genetics · doi:10.1038/ng1871 · Cited by 354 · see citing works
Self-citationDespriet, D. D. G., Klaver, C. C. W., Witteman, J. C. M., Bergen, A. A. B., Kardys, I., de Maat, M. P. M., Boekhoorn, S. S., Vingerling, J. R., Hofman, A., Oostra, B. A., et al. (2006) · JAMA · doi:10.1001/jama.296.3.301 · Cited by 348 · see citing works
The Genetics of Age-Related Macular Degeneration: A Review of Progress to Date
Haddad, S., Chen, C. A., Santangelo, S. L., & Seddon, J. M. (2006) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2006.05.001 · Cited by 299 · see citing works
Swaroop, A., Chew, E. Y., Bowes Rickman, C., & Abecasis, G. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164350 · Cited by 270 · see citing works
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Fisher, S. A., Abecasis, G. R., Yashar, B. M., Zareparsi, S., Swaroop, A., Iyengar, S. K., Klein, B. E. K., Klein, R., Lee, K. E., Majewski, J., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi230 · Cited by 239 · see citing works
Self-citationCFH Y402H confers similar risk of soft drusen and both forms of advanced AMD
Magnusson, K. P., Duan, S., Sigurdsson, H., Petursson, H., Yang, Z., Zhao, Y., Bernstein, P. S., Ge, J., Jonasson, F., Stefansson, E., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0030005 · Cited by 226 · see citing works
Self-citationWeeks, D. E., Conley, Y. P., Tsai, H.-J., Mah, T. S., Schmidt, S., Postel, E. A., Agarwal, A., Haines, J. L., Pericak-Vance, M. A., Rosenfeld, P. J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422476 · Cited by 195 · see citing works
Zareparsi, S., Buraczynska, M., Branham, K. E. H., Shah, S., Eng, D., Li, M., Pawar, H., Yashar, B. M., Moroi, S. E., Lichter, P. R., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi154 · Cited by 190 · see citing works
Self-citationHaines, J. L., Schnetz-Boutaud, N., Schmidt, S., Scott, W. K., Agarwal, A., Postel, E. A., Olson, L., Kenealy, S. J., Hauser, M., Gilbert, J. R., et al. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-0116 · Cited by 189 · see citing works
Swaroop, A., Branham, K. E., Chen, W., & Abecasis, G. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm212 · Cited by 173 · see citing works
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Self-citationConley, Y. P., Thalamuthu, A., Jakobsdottir, J., Weeks, D. E., Mah, T., Ferrell, R. E., & Gorin, M. B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi204 · Cited by 158 · see citing works
Zareparsi, S. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-1253 · Cited by 145 · see citing works
Self-citationChen, H., Liu, B., Lukas, T. J., & Neufeld, A. H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002339 · Cited by 129 · see citing works
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Kaur, I., Hussain, A., Hussain, N., Das, T., Pathangay, A., Mathai, A., Hussain, A., Nutheti, R., Nirmalan, P. K., & Chakrabarti, S. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1430 · Cited by 84 · see citing works
Evidence for association between multiple complement pathway genes and AMD
Dinu, V., Miller, P. L., & Zhao, H. (2007) · Genetic Epidemiology · doi:10.1002/gepi.20204 · Cited by 58 · see citing works
- Authors
- Abecasis, G. R., Yashar, B. M., Zhao, Y., Ghiasvand, N. M., Zareparsi, S., Branham, K. E. H., Reddick, A. C., Trager, E. H., Yoshida, S., Bahling, J., Filippova, E., Elner, S., Johnson, M. W., Vine, A. K., Sieving, P. A., Jacobson, S. G., Richards, J. E., & Swaroop, A.
- Affiliations
- University of Michigan (US)
- University of Pennsylvania (US)
- Corresponding author
- Swaroop, Anand
- ORCID
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 74
- Issue
- 3
- Pages
- 482-494
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC1182262
- OpenAlex
- W2168511422
- Cited by
- 182
- References
- 50
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 11 · 2015: 2 · 2014: 5 · 2013: 13 · 2012: 8
- FWCI
- 29.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Federation for Aging Research
- Foundation Fighting Blindness
- Research to Prevent Blindness
- Macula Vision Research Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Eye Institute (F32EY014085)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- age-related macular degeneration, genetic susceptibility loci, geographic atrophy, choroidal neovascularization, nonparametric linkage analysis, affected relative pairs, multipoint linkage analysis
- MeSH terms
- Aging, Chromosome Mapping, Humans, Macular Degeneration, Statistics, Nonparametric, Genetic Predisposition to Disease
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