[37] Carbonyl assays for determination of oxidatively modified proteins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961

Free radicals, oxidative stress, and antioxidants in human health and disease

Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682

The oxidative environment and protein damage

Davies, M. J. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.08.007 · Cited by 1,392

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.014 · Cited by 782

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

Elchuri, S., Oberley, T. D., Qi, W., Eisenstein, R. S., Jackson Roberts, L., Van Remmen, H., Epstein, C. J., & Huang, T.-T. (2005) · Oncogene · doi:10.1038/sj.onc.1208207 · Cited by 667

Protein Oxidation in Aging and Age‐Related Diseases

Stadtman, E. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05632.x · Cited by 660

Proteomic identification of oxidatively modified proteins in Alzheimer’s disease brain. Part I: Creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1

Castegna, A., Aksenov, M., Aksenova, M., Thongboonkerd, V., Klein, J. B., Pierce, W. M., Booze, R., Markesbery, W. R., & Butterfield, D. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00914-0 · Cited by 581

Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564

Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders

MACFABE, D., CAIN, D., RODRIGUEZCAPOTE, K., FRANKLIN, A., HOFFMAN, J., BOON, F., TAYLOR, A., KAVALIERS, M., & OSSENKOPP, K. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.025 · Cited by 497

Simplified 2,4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins

Mesquita, C. S., Oliveira, R., Bento, F., Geraldo, D., Rodrigues, J. V., & Marcos, J. C. (2014) · Analytical Biochemistry · doi:10.1016/j.ab.2014.04.034 · Cited by 480

Stable markers of oxidant damage to proteins and their application in the study of human disease

Davies, M. J., Fu, S., Wang, H., & Dean, R. T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00206-3 · Cited by 461

Oxidative stress in Alzheimer disease

Gella, A., & Durany, N. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.1.7402 · Cited by 459

Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins

Requena, J. R., Chao, C.-C., Levine, R. L., & Stadtman, E. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.69 · Cited by 415

Mitochondria-Targeted Small Molecule Therapeutics and Probes

Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3969 · Cited by 399

Chapter 7 Protein Oxidation Processes in Aging Brain

Butterfield, D. A., & Stadtman, E. R. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60057-7 · Cited by 390

Regulation of cell function by methionine oxidation and reduction

Hoshi, T., & Heinemann, S. H. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0001j.x · Cited by 384

Oxidative stress, protein modification and Alzheimer disease

Tramutola, A., Lanzillotta, C., Perluigi, M., & Butterfield, D. A. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.06.005 · Cited by 303

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Minato, N., Klausner, R. D., Levine, R. L., & Rouault, T. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4924 · Cited by 293

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

Estrada, J. C., Albo, C., Benguría, A., Dopazo, A., López-Romero, P., Carrera-Quintanar, L., Roche, E., Clemente, E. P., Enríquez, J. A., Bernad, A., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.172 · Cited by 297

Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions

Weber, D., Davies, M. J., & Grune, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.005 · Cited by 295

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

Reed, T., Perluigi, M., Sultana, R., Pierce, W. M., Klein, J. B., Turner, D. M., Coccia, R., Markesbery, W. R., & Butterfield, D. A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.12.007 · Cited by 257

Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae

Reverter-Branchat, G., Cabiscol, E., Tamarit, J., & Ros, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404849200 · Cited by 218

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

Rodriguez-Cuenca, S., Cochemé, H. M., Logan, A., Abakumova, I., Prime, T. A., Rose, C., Vidal-Puig, A., Smith, A. C., Rubinsztein, D. C., Fearnley, I. M., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.039 · Cited by 218

Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

Sultana, R., Perluigi, M., & Butterfield, D. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0517-0 · Cited by 215

Oxidatively damaged proteins of heart mitochondrial electron transport complexes

Choksi, K. B., Boylston, W. H., Rabek, J. P., Widger, W. R., & Papaconstantinou, J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.11.007 · Cited by 212

Protein separation by capillary gel electrophoresis: A review

Zhu, Z., Lu, J. J., & Liu, S. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.10.022 · Cited by 202

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

Tomaru, U., Takahashi, S., Ishizu, A., Miyatake, Y., Gohda, A., Suzuki, S., Ono, A., Ohara, J., Baba, T., Murata, S., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.11.012 · Cited by 185

Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males

Ahmad, M. K., Mahdi, A. A., Shukla, K. K., Islam, N., Rajender, S., Madhukar, D., Shankhwar, S. N., & Ahmad, S. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.04.046 · Cited by 179

Cytokine Profile in Quadriceps Muscles of Patients with Severe COPD

Barreiro, E., Schols, A. M. W. J., Polkey, M. I., Galdiz, J. B., Gosker, H. R., Swallow, E. B., Coronell, C., Gea, J., & on behalf of the ENIGMA in COPD project (2007) · Thorax · doi:10.1136/thx.2007.078030 · Cited by 175

Protein oxidative damage in the stratum corneum: evidence for a link between environmental oxidants and the changing prevalence and nature of atopic dermatitis in Japan.

Niwa, Y., Sumi, H., Kawahira, K., Terashima, T., Nakamura, T., & Akamatsu, H. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05417.x · Cited by 152

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide

Lillig, C. H., Lönn, M. E., Enoksson, M., Fernandes, A. P., & Holmgren, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401896101 · Cited by 147

Hypoxaemia Enhances Peripheral Muscle Oxidative Stress in Chronic Obstructive Pulmonary Disease

Koechlin, C. (2005) · Thorax · doi:10.1136/thx.2004.037531 · Cited by 143

Elevated free radical products in the cerebrospinal fluid of VLBW infants with cerebral white matter injury

Inder, T., Mocatta, T., Darlow, B., Spencer, C., Volpe, J. J., & Winterbourn, C. (2002) · Pediatric Research · doi:10.1203/00006450-200208000-00013 · Cited by 125

Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer’s disease

Sultana, R., Perluigi, M., Newman, S. F., Pierce, W. M., Cini, C., Coccia, R., & Butterfield, D. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2810 · Cited by 125

Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus

Réus, G. Z., Stringari, R. B., de Souza, B., Petronilho, F., Dal-Pizzol, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.5.13109 · Cited by 110

Muscle and Blood Redox Status after Exercise Training in Severe COPD Patients

Rodriguez, D. A., Kalko, S., Puig-Vilanova, E., Perez-Olabarría, M., Falciani, F., Gea, J., Cascante, M., Barreiro, E., & Roca, J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.022 · Cited by 102

Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction

Berthiaume, J. M., Oliveira, P. J., Fariss, M. W., & Wallace, K. B. (2005) · Cardiovascular Toxicology · doi:10.1385/ct:5:3:257 · Cited by 101

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

Perluigi, M., di Domenico, F., Fiorini, A., Cocciolo, A., Giorgi, A., Foppoli, C., Butterfield, D. A., Giorlandino, M., Giorlandino, C., Eugenia Schininà, M., et al. (2011) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201000121 · Cited by 97

Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Aβ(1-42): Implications for Alzheimer’s Disease

Boyd-Kimball, D., Poon, H. F., Lynn, B. C., Cai, J., Pierce Jr., W. M., Klein, J. B., Ferguson, J., Link, C. D., & Butterfield, D. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.001 · Cited by 98

The Ferroxidase Activity of Yeast Frataxin

Park, S., Gakh, O., Mooney, S. M., & Isaya, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206711200 · Cited by 88

Huntingtin inclusion bodies are iron‐dependent centers of oxidative events

Firdaus, W. J. J., Wyttenbach, A., Giuliano, P., Kretz‐Remy, C., Currie, R. W., & Arrigo, A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05537.x · Cited by 71

HdaA, a Major Class 2 Histone Deacetylase of Aspergillus nidulans , Affects Growth under Conditions of Oxidative Stress

Tribus, M., Galehr, J., Trojer, P., Brosch, G., Loidl, P., Marx, F., Haas, H., & Graessle, S. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.10.1736-1745.2005 · Cited by 67

Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease: Insights into Pathophysiology and Treatment

Alkhalifa, A. E., Alkhalifa, O., Durdanovic, I., Ibrahim, D. R., & Maragkou, S. (2025) · Journal of Dementia and Alzheimer's Disease · doi:10.3390/jdad2020017 · Cited by 66

Analysis of protein carbonylation — pitfalls and promise in commonly used methods

Rogowska-Wrzesinska, A., Wojdyla, K., Nedić, O., Baron, C. P., & Griffiths, H. R. (2014) · Free Radical Research · doi:10.3109/10715762.2014.944868 · Cited by 65

Role of Protein Carbonylation in Skeletal Muscle Mass Loss Associated with Chronic Conditions

Barreiro, E. (2016) · Proteomes · doi:10.3390/proteomes4020018 · Cited by 56

Protective Effect of D609 Against Amyloid-Beta1-42-Induced Oxidative Modification of Neuronal Proteins: Redox Proteomics Study

Sultana, R., Newman, S. F., Abdul, H. M., Cai, J., Pierce, W. M., Klein, J. B., Merchant, M., & Butterfield, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20876 · Cited by 53

Oxidation of Arg‐410 promotes the elimination of human serum albumin

Iwao, Y., Anraku, M., Yamasaki, K., Kragh-Hansen, U., Kawai, K., Maruyama, T., & Otagiri, M. (2006) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2006.01.011 · Cited by 53

Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration

Di Domenico, F., Head, E., Butterfield, D. A., & Perluigi, M. (2014) · Advances in Geriatrics · doi:10.1155/2014/527518 · Cited by 50

Hypochlorous Acid Alters Bronchial Epithelial Cell Membrane Properties and Prevention by Extracellular Glutathione

Venglarik, C. J., Girón-Calle, J., Wigley, A. F., Malle, E., Watanabe, N., & Forman, H. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00002.2003 · Cited by 48

Coenzyme Q10 Supplementation Reverses Age-Related Impairments in Spatial Learning and Lowers Protein Oxidation

Shetty, R. A., Forster, M. J., & Sumien, N. (2013) · AGE · doi:10.1007/s11357-012-9484-9 · Cited by 47

Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain

Valvassori, S. S., Dal-Pont, G. C., Steckert, A. V., Varela, R. B., Lopes-Borges, J., Mariot, E., Resende, W. R., Arent, C. O., Carvalho, A. F., & Quevedo, J. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2015.11.017 · Cited by 44

Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways

Navarro-Yepes, J., Anandhan, A., Bradley, E., Bohovych, I., Yarabe, B., de Jong, A., Ovaa, H., Zhou, Y., Khalimonchuk, O., Quintanilla-Vega, B., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9414-9 · Cited by 37

Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome

Parisotto, E. B., Garlet, T. R., Cavalli, V. L. D. L. O., Zamoner, A., da Rosa, J. S., Bastos, J., Micke, G. A., Fröde, T. S., Pedrosa, R. C., & Wilhelm Filho, D. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.03.013 · Cited by 34

Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

Mendonça, B. P., Cardoso, J. D. S., Michels, M., Vieira, A. C., Wendhausen, D., Manfredini, A., Singer, M., Dal-Pizzol, F., & Dyson, A. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00300-8 · Cited by 21

Dietary coconut sprout beneficially modulates cardiac damage induced by isoproterenol in rats

Chikku, A. M., & Rajamohan, T. (2012) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v7i4.12143 · Cited by 20

Oxidative Stress and Annexin A2 Differential Expression in Free Fatty Acids-Induced Non-Alcoholic Fatty Liver Disease in HepG2 Cells

Arruda, V. M., Azevedo, G. T., Granato, M. J. M. G., Matos, A. C. P., Araújo, T. G., & Guerra, J. F. D. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179591 · Cited by 13

Oxidative stress time course in the rat diaphragm after freezing–thawing cycles

Sellares, J., Mas, S., Melo, E., Sánchez, F., Marin, J., Gea, J., & Barreiro, E. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2006.05.008 · Cited by 7

Peripheral Activation of Formyl Peptide Receptor 2/ALX by Electroacupuncture Alleviates Inflammatory Pain by Increasing Interleukin-10 Levels and Catalase Activity in Mice

Tanaka, F., Mazzardo, G., Salm, D. C., de Oliveira, B. H., Joaquim, L., Machado, R. S., Cidreira, T., Petronilho, F. C., Bittencourt, E. B., Bianco, G., et al. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.08.004 · Cited by 4