Structure of Bax

Protein backbone angle restraints from searching a database for chemical shift and sequence homology

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Cell Death

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The Bcl2 family: regulators of the cellular life-or-death switch

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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

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Mitochondria and cell death: outer membrane permeabilization and beyond

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

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BCL-2 family proteins: changing partners in the dance towards death

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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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The many roles of FAS receptor signaling in the immune system

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VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

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Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

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Structural biology of the Bcl-2 family of proteins

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Mechanisms of Action of Bcl-2 Family Proteins

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BAX activation is initiated at a novel interaction site

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Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

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A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

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Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

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Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

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The BCL-2 arbiters of apoptosis and their growing role as cancer targets

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Mitochondrial Regulation of Cell Death

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JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

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The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy

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Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

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Many players in BCL-2 family affairs

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A Stapled BID BH3 Helix Directly Binds and Activates BAX

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Control of mitochondrial permeability by Bcl-2 family members

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Yeast and apoptosis

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Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

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BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

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Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

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Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

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Structural Model of Active Bax at the Membrane

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The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

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Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis

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Bax dimerizes via a symmetric BH3:groove interface during apoptosis

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Differential retrotranslocation of mitochondrial Bax and Bak

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BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

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Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

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Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

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Crosstalk between apoptosis and autophagy signaling pathways

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BH3‐in‐groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

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Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax

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Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers

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Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation

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Assembly of the Bak Apoptotic Pore

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Organization of the Mitochondrial Apoptotic BAK Pore

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Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin

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Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

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The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID

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The Incomplete Puzzle of the BCL2 Proteins

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Mitochondrial Function and Neurodegenerative Diseases

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Computational design of Bax-inhibiting peptides

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Optogenetic engineering of BAX to control mitochondrial permeabilization and attenuate apoptosis in cells

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