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Cited by 968Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

The DOI matches its Crossref record; 73 of the 76 references it cites were found in a registry or an index.

OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS1The purpose of this paper is to describe the neuroendocrine mechanisms of positive social interactions.1

Uvnäs-Moberg, Kerstin·1998·Psychoneuroendocrinology
DOI 10.1016/s0306-4530(98)00056-0
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Abstract

During breastfeeding or suckling, maternal oxytocin levels are raised by somatosensory stimulation. Oxytocin may, however, also be released by nonnoxious stimuli such as touch, warm temperature etc. in plasma and in cerebrospinal fluid. Consequently, oxytocin may be involved in physiological and behavioral effects induced by social interaction in a more general context. In both male and female rats oxytocin exerts potent physiological antistress effects. If daily oxytocin injections are repeated over a 5-day period, blood pressure is decreased by 10-20 mmHg, the withdrawal latency to heat stimuli is prolonged, cortisol levels are decreased and insulin and cholecystokinin levels are increased. These effects last from 1 to several weeks after the last injection. After repeated oxytocin treatment weight gain may be promoted and the healing rate of wounds increased. Most behavioral and physiological effects induced by oxytocin can be blocked by oxytocin antagonists. In contrast, the antistress effects can not, suggesting that unidentified oxytocin receptors may exist. The prolonged latency in the tail-flick test can be temporarily reversed by administration of naloxone, suggesting that endogenous opioid activity has been increased by the oxytocin injections. In contrast, the long-term lowering of blood pressure and of cortisol levels as well as the sedative effects of oxytocin have been found to be related to an increased activity of central alpha 2-adrenoceptors. Positive social interactions have been related to health-promoting effects. Oxytocin released in response to social stimuli may be part of a neuroendocrine substrate which underlies the benefits of positive social experiences. Such processes may in addition explain the health-promoting effects of certain alternative therapies. Because of the special properties of oxytocin, including the fact that it can become conditioned to psychological state or imagery, oxytocin may also mediate the benefits attributed to therapies such as hypnosis or meditation.

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Research works printed but not linked: 2

  1. Aston-Jones, J. G., Foote, S. L., Bloom, F. E. (1984) Anatomy and physiology of locus coeruleus neurons: functional implications. In: Ziegler, M., Lohe, C.R. (Eds.) Norepinephrine. Wilkins and Wilkins, Baltimore, MD. Frontiers in Clinical Neuroscience 2, 92–116.
  2. Petersson, 1996, Oxytocin increases nociceptive pain threshold in a long-term perspective in female and male rats, Neuroscience, 212, 87

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Metadata

Authors
Uvnäs-Moberg, K.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
1998-11
Volume
23
Issue
8
Pages
819-835
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/s0306-4530(98)00056-0
OpenAlex
W1878549597
Cited by
966
References
76
Citations by year
2026: 28 · 2025: 20 · 2024: 37 · 2023: 26 · 2022: 27 · 2021: 37 · 2020: 34 · 2019: 30 · 2018: 47 · 2017: 42 · 2016: 47 · 2015: 49 · 2014: 40 · 2013: 52 · 2012: 44
FWCI
22.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
oxytocin, positive social interaction, social behavior, neuroendocrine mechanisms, anti-stress effects, blood pressure, cortisol, insulin, cholecystokinin, oxytocin antagonist, naloxone, endogenous opioids, alpha2-adrenoceptors, wound healing, health-promoting properties, hypnosis, meditation, complementary and alternative medicine
MeSH terms
Animals, Breast Feeding, Emotions, Female, Humans, Interpersonal Relations, Lactation, Male, Neurosecretory Systems, Object Attachment, Oxytocin, Parents

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