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OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS1The purpose of this paper is to describe the neuroendocrine mechanisms of positive social interactions.1
Abstract
During breastfeeding or suckling, maternal oxytocin levels are raised by somatosensory stimulation. Oxytocin may, however, also be released by nonnoxious stimuli such as touch, warm temperature etc. in plasma and in cerebrospinal fluid. Consequently, oxytocin may be involved in physiological and behavioral effects induced by social interaction in a more general context. In both male and female rats oxytocin exerts potent physiological antistress effects. If daily oxytocin injections are repeated over a 5-day period, blood pressure is decreased by 10-20 mmHg, the withdrawal latency to heat stimuli is prolonged, cortisol levels are decreased and insulin and cholecystokinin levels are increased. These effects last from 1 to several weeks after the last injection. After repeated oxytocin treatment weight gain may be promoted and the healing rate of wounds increased. Most behavioral and physiological effects induced by oxytocin can be blocked by oxytocin antagonists. In contrast, the antistress effects can not, suggesting that unidentified oxytocin receptors may exist. The prolonged latency in the tail-flick test can be temporarily reversed by administration of naloxone, suggesting that endogenous opioid activity has been increased by the oxytocin injections. In contrast, the long-term lowering of blood pressure and of cortisol levels as well as the sedative effects of oxytocin have been found to be related to an increased activity of central alpha 2-adrenoceptors. Positive social interactions have been related to health-promoting effects. Oxytocin released in response to social stimuli may be part of a neuroendocrine substrate which underlies the benefits of positive social experiences. Such processes may in addition explain the health-promoting effects of certain alternative therapies. Because of the special properties of oxytocin, including the fact that it can become conditioned to psychological state or imagery, oxytocin may also mediate the benefits attributed to therapies such as hypnosis or meditation.
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“The analgesic effects of exogenous oxytocin in humans identify the oxytocin system as a plausible neural mechanism for the transduction of the effects of social support into the neural and physiological changes that modulate the experience of pain in humans 81”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [81]
In the citing paper
“As a final effect of oxytocin, it is thought that under certain circumstances, oxytocin may activate a positive feedback system, such that oxytocin may trigger a behavior or motivation, or vice versa. Then, the behavior or motivation may trigger further oxytocin release, which may again initiate more of the behavior (Uvnäs-Moberg, 1998; De Dreu, 2012).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Uvnäs-Moberg, 1998
In the citing paper
“There are indications for this in the context of labor during child birth (Russell et al., 2003), and this is hypothesized, for example, in the context of affiliation (Uvnäs-Moberg, 1998) and cooperation (see De Dreu, 2012).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Uvnäs-Moberg, 1998
In the citing paper
“Positive tactile stimuli (touch, warmth, odors) can release oxytocin (Uvnäs-Moberg, 1998)”
From The impact of atypical sensory processing on social impairments in autism spectrum disorder (2018) · cites this paper as Uvnäs-Moberg, 1998
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BackgroundAn Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support
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Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
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“…evidence suggests the intriguing hypothesis that OT released during positive social interactions reduces the HPA axis response to stressful events (Uvnas-Moberg, 1998), and in humans, may account for the extensive evidence that social support protects against the onset of stress-related…”
BackgroundFleming, A. S., Kraemer, G. W., Gonzalez, A., Lovic, V., Rees, S., & Melo, A. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00793-1 · Cited by 203
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Social Interaction Deficits Caused by Chronic Phencyclidine Administration are Reversed by Oxytocin
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“Researchers have theorized that OT is intimately involved the rewarding effects of touch (for a review, Uvnas-Moberg, 1998).”
BackgroundAnxiety, cortisol, and attachment predict plasma oxytocin
Tops, M., Van Peer, J. M., Korf, J., Wijers, A. A., & Tucker, D. M. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00510.x · Cited by 197
“It is also consistent with the animal and human literature implicating oxytocin in attachment and positive social interactions (Carter, 1998; Uvnäs-Moberg, 1998).”
ResultClaxton, A. M. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.03.002 · Cited by 198
“For example, an increase in oxytocin released in response to social stimuli in laboratory-housed rats was believed to lead to health benefits such as weight gain and lowering of blood pressure (Uvnas-Moberg, 1998).”
BackgroundEvidence for bivariate systems: An empirical test of appetition and aversion across domains
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“, Kiecolt-Glaser, Glaser, Cacioppo, & Malarkey, 1998), whereas, affectionate exchanges are associated with increased oxytocin levels (Carter, 1992; Uvnaes-Moberg, 2000).”
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“These effects induced are of course health promoting and may be one of the reasons why people with good social relations have a better health [120, 121, 122].”
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Beetz, A., Kotrschal, K. M., Turner, D. C., Hediger, K., Uvnäs‐Moberg, K., & Julius, H. (2011) · Anthrozoös · doi:10.2752/175303711x13159027359746 · Cited by 227
“In addition, tactile 36 2 A nt hr oz oö s interaction by children may release even more oxytocin (Stock and Uvnäs-Moberg 1998), in response to activation of non-noxious sensory nerves (the “deep” system of free nerve endings) by physical contact (Petersson, Hulting and Uvnäs-Moberg 1999; Matthiesen…”
BackgroundSelf-citationTriune ethics: The neurobiological roots of our multiple moralities
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“Oxytocin also counteracts the effects of stress by decreasing blood pressure and reducing activity in the sympathetic autonomic system (Uvnas-Moberg, 1997, 1998).”
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The Person in Context: A Holistic‐Interactionistic Approach
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“No higher cognitive setup is necessary for this mechanism, but it may be mediated by neurological or hormonal changes (Uvnas Moberg 1998; White and Hiroi 1998; Rilling et al. 2002; Kosfeld et al. 2005).”
BackgroundUnternaehrer, E., Meyer, A. H., Burkhardt, S. C. A., Dempster, E., Staehli, S., Theill, N., Lieb, R., & Meinlschmidt, G. (2015) · Stress · doi:10.3109/10253890.2015.1038992 · Cited by 181
“The oxytocin receptor gene (OXTR) was included as a second candidate gene, because oxytocin signaling modulates the stress response centrally as well as peripherally (Carter, 2003; Petersson et al., 1999; Uvnas-Moberg, 1998) and plays a crucial role in maternal behaviors (Russell et al.”
BackgroundBrown, S. L., & Brown, R. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.004 · Cited by 212
Effects of affiliation and power motivation arousal on salivary progesterone and testosterone
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“…induced by affiliation arousal may reflect a surge in oxytocin, a hormone that has a central role in attachment and affiliation (Insel, 1992; Uvnäs-Moberg, 1998) and that stimulates the release of P from the gonads independently of effects of luteinizing hormone in vitro (cf. Adashi et…”
BackgroundBreastfeeding Duration, Costs, and Benefits of a Support Program for Low‐Income Breastfeeding Women
Pugh, L. C., Milligan, R. A., Frick, K. D., Spatz, D. L., & Bronner, Y. (2002) · Birth · doi:10.1046/j.1523-536x.2002.00169.x · Cited by 182
“Increased duration of breastfeeding offers health benefits to mothers and infants (3,7,8), many of which are specific to low-income women.”
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Balasco, L., Provenzano, G., & Bozzi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01016 · Cited by 209
Oxytocin and Pain: A Systematic Review and Synthesis of Findings
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Shiota, M. N., & Levenson, R. W. (2012) · Journal of Personality and Social Psychology · doi:10.1037/a0029208 · Cited by 174
McGregor, I. S., Callaghan, P. D., & Hunt, G. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.132 · Cited by 171
“It is therefore interesting to note that OT has marked inhibitory effects on activation of the hypothalamic pituitary adrenal axis (Uvnas-Moberg, 1998; Legros, 2001; Windle et al., 2004) and centrally administered OT, but not AVP, exerts a potent action in suppressing stress-induced Fos expression…”
BackgroundAdvances in human oxytocin measurement: challenges and proposed solutions
Tabak, B. A., Leng, G., Szeto, A., Parker, K. J., Verbalis, J. G., Ziegler, T. E., Lee, M. R., Neumann, I. D., & Mendez, A. J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01719-z · Cited by 170
“In addition to the brain [58], oxytocin receptors (OXTR) are expressed in most organs throughout the body, including the reproductive tissues, heart, kidney, bone, and autonomic nervous system [1], suggesting that oxytocin’s effects on the periphery may also contribute to changes in behavior [33, 59].”
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Silvers, J. A., & Haidt, J. (2008) · Emotion · doi:10.1037/1528-3542.8.2.291 · Cited by 182
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“Since oxytocin functions as an anti-depressant agent, reducing anxiety and elevating social activity in humans (Carter, 1998; Uvnas-Moberg, 1998) and is increased with touch and contact, it is likely to play a role in the general complex of behavior and mental representations related to maternal caregiving.”
BackgroundTactile stimulation lowers stress in fish
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“Oxytocin is the hormone of reproduction (uterine contractions, milk ejection reflex), but it also the social hormone, often called the affiliation hormone (Nissen et al., 1996; Ross & Young, 2009; Uvnas-Moberg, 1998).”
BackgroundPredictors of Continuation of Exclusive Breastfeeding for the First Six Months of Life
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“These changes include emotional benefits of EBF, for example, promoting warmth and thus bonding between the mother and the baby and stress-relieving effects on the mother.(31-33) Stress-relieving effects on the mother are manifested by a reduction in blood pressure and cortisol level in each lactation session.”
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“Consequently, OT is thought to buffer against physical and emotional stressors (Uvnas-Moberg 1998; Neumann 2002; Smith and Wang 2014; Ditzen and Heinrichs 2014).”
BackgroundChristopher, M. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2003.12.003 · Cited by 164
Animal welfare with and without consciousness
Dawkins, M. S. (2017) · Journal of Zoology · doi:10.1111/jzo.12434 · Cited by 174
“For more positive emotions, the hormone oxytocin, 282 which is found in both humans and other mammals, is commonly released during tactile 283 contact such as nursing, mating, grooming and massage and used as an indication of good 284 welfare (Uvnäis-Moberg, 1998).”
BackgroundMonetary sacrifice among strangers is mediated by endogenous oxytocin release after physical contact
MORHENN, V, PARK, J., PIPER, E., & ZAK, P. (2008) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2008.04.004 · Cited by 158
“Our finding that women DM2s showed a stronger priming effect from massage may have evolved from mammalian attachment mechanisms in which offspring grasping at the mother's breast induces OT release absent suckling (Matthiesen, 2001; Uvnas-Moberg, 1998).”
BackgroundSelçuk, E., Vivian Zayas, A., Günaydın, G., Hazan, C., & Kross, E. F. (2012) · Journal of Personality and Social Psychology · doi:10.1037/a0028125 · Cited by 154
Effects of Stress on Lactation
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“OT is known for its calming, antinociceptive effects and is associated with positive social interactions both during development and in adulthood (Carter, 1998; Insel & Winslow, 1991; Uvnas-Moberg, 1998).”
BackgroundLactation and Stress: Protective Effects of Breast-feeding in Humans
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“…reproduction-related social behavior (e.g. attachment, sexual behavior, pair bonding, maternal behavior), cognitive performance (learning, memory), and stress (Carter and Altemus, 1997; McCarthy and Altemus, 1997; Pedersen, 1997; Uvnäs-Moberg, 1998; Heinrichs, 2000; Kendrick, 2000; Legros, 2001).”
The role of oxytocin in male and female reproductive behavior
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“Prior research on human and animal models have demonstrated several health and psychological benefits to breastfeeding, resulting from the positive effects of OT.”
InfluentialBales, K. L., Plotsky, P. M., Young, L. J., Lim, M. M., Grotte, N., Ferrer, E., & Carter, C. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.009 · Cited by 150
“Breast milk contains OT (Leake et al., 1981), and OT is also released by warmth and touch (Uvnas-Moberg, 1998).”
Mattie Tops, A., Buisman‐Pijlman, F. T. A., Boksem, M. A. S., Wijers, A. A., & Korf, J. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00043 · Cited by 150
“, 2007a,b): oxytocin inhibits or downregulates stress responses, seems to inhibit acquisition and/or consolidation of aversive, high arousal experiences, and has analgesic effects (Uvnäs-Moberg, 1998; Lee et al., 2009).”
BackgroundKully‐Martens, K., Denys, K., Treit, S., Tamana, S. K., & Rasmussen, C. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01661.x · Cited by 172
Gordon, I., Zagoory‐Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.04.007 · Cited by 148
Low CSF oxytocin reflects high intent in suicide attempters
Jokinen, J., Chatzittofis, A., Hellström, C., Nordström, P., Uvnäs-Moberg, K., & Åsberg, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.016 · Cited by 143
“Oxytocin functions as both a neurotransmitter and hormone, and is implicated in learning, memory, affiliation, trust, social behaviours, depression, anxiety, fear and aggression with possible implications in autism, schizophrenia, depression and anxiety disorders (Uvnäs-Moberg, 1998; Heinrichs et al., 2009).”
BackgroundSelf-citationGrewen, K. M., Davenport, R. E., & Light, K. C. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00968.x · Cited by 146
“…behaviors, OT has also been linked to health-promoting cardiovascular (Diaz-Cabiale et al., 2000; Holst, UvnasMoberg, & Petersson, 2002; Knox & Uvnas-Moberg, 1998; Petersson, Lundeberg, & Uvnas-Moberg, 1999), metabolic (Bjorkstrand, Hulting, Meister, & Uvnas-Moberg, 1993; Petersson, Hulting,…”
Mattie Tops, A., Koole, S. L., IJzerman, H., & Buisman‐Pijlman, F. T. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.015 · Cited by 146
Developmental experiences and the oxytocin receptor system
Bales, K. L., & Perkeybile, A. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.013 · Cited by 142
“We are also assuming that high levels of OT may be induced by either positive social stimuli, such as warmth, touch, and high levels of parenting (Uvnas-Moberg, 1998), as well as negative social stimuli such as separation from the attachment figure or other distressed relationships (Grippo et al.,…”
Buisman‐Pijlman, F. T. A., Sumracki, N. M., Gordon, J. J., Hull, P. R., Carter, C. S., & Tops, M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.005 · Cited by 147
“…and reduce pain (Bartz et al., 2011; Baskerville and Douglas, 2010; Carter, 1998; Lemaire et al., 2002; McGregor and Bowen, 2012; Sarnyai and Kovács, 1994; Smith and Wang, 2012; Tops et al., 2012; Uvnäs-Moberg, 1998; Veenema and Neumann 2008; Waldherr and Neumann, 2007; Weisman et al., 2012).”
Communicating affection: interpersonal behavior and social context
(2007) · Choice Reviews Online · doi:10.5860/choice.44-3351 · Cited by 142
Detection of salivary oxytocin levels in lactating women
White‐Traut, R., Watanabe, K., Pournajafi‐Nazarloo, H., Schwertz, D., Bell, A., & Carter, C. S. (2009) · Developmental Psychobiology · doi:10.1002/dev.20376 · Cited by 142
Burleson, M. H., Trevathan, W. R., & Todd, M. W. (2006) · Archives of Sexual Behavior · doi:10.1007/s10508-006-9071-1 · Cited by 143
Neural correlates of giving support to a loved one
Inagaki, T. K., & Eisenberger, N. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182359335 · Cited by 141
“Moreover, OT aids the regulation of stress by dampening physiological stress responses, leading to an anxiolytic, calming effect (33,34) and reduced amygdala activity to fearful stimuli (35).”
BackgroundPierrehumbert, B., Torrisi, R., Laufer, D., Halfon, O., Ansermet, F., & Beck Popovic, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.016 · Cited by 139
Oxytocin and Pain Perception: From Animal Models to Human Research
Boll, S., de Minas, A. C. A., Raftogianni, A., Herpertz, S. C., & Grinevich, V. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.041 · Cited by 141
Wirth, M. M., & Schultheiss, O. C. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.08.003 · Cited by 145
Yu, H., Miao, W., Ji, E., Huang, S., Jin, S., Zhu, X., Liu, M.-Z., Sun, Y.-G., Xu, F., & Yu, X. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.022 · Cited by 144
Contributions of Psychophysiology to Research on Adult Attachment: Review and Recommendations
Diamond, L. M. (2001) · Personality and Social Psychology Review · doi:10.1207/s15327957pspr0504_1 · Cited by 139
A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135
Snowdon, C. T., Pieper, B. A., Boe, C. Y., Cronin, K. A., Kurian, A. V., & Ziegler, T. E. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.014 · Cited by 133
“Some studies have shown that sexual activities as well as gentle stroking and touching can elicit increased oxytocin levels in humans (Uvnäs-Moberg, 1998; Krüger et al., 2003; Light et al., 2005).”
BackgroundChapter 17 Neuroendocrine and emotional changes in the post-partum period
Carter, C. S., Altemus, M. M., & Pchrousos, G. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33018-2 · Cited by 133
Social Neuroscience: Progress and Implications for Mental Health
Cacioppo, J. T., Amaral, D. G., Blanchard, J. J., Cameron, J. L., Carter, C. S., Crews, D., Fiske, S., Heatherton, T., Johnson, M. K., Kozak, M. J., et al. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00032.x · Cited by 135
“Positive social interactions promote the release of oxytocin in the brain, which promotes social bonding and down-regulates reactivity to stressors (Uvnäs-Moberg, 1998).”
Beech, A. R., & Mitchell, I. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.10.002 · Cited by 135
“In humans vaginal birth and breast-feeding, which are both associated with increased oxytocin release, are correlated with behavioral changes, including good attachment formation between infant and mother (Nissen, Gustavsson, Widstrom, & Uvnas-Moberg, 1998; Sjogren, Widstrom, Edman, & UvnasMoberg, 2000; Uvnas-Moberg,…”
BackgroundLong-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131
Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism
İşeri, S. Ö., Şener, G., Saǧlam, B., Gedik, N., Ercan, F., & Yeğen, B. Ç. (2004) · Peptides · doi:10.1016/j.peptides.2004.10.005 · Cited by 131
Norholt, H. (2020) · Infant Behavior and Development · doi:10.1016/j.infbeh.2020.101441 · Cited by 148
Massage and touch for dementia
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Beyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and Emotion
Wirth, M. M. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00019 · Cited by 121
“…stress and exert anxiolytic effects www.frontiersin.org August 2011 | Volume 2 | Article 19 | 7 (Akil et al., 1984; Kalin et al., 1988; Hashimoto et al., 1989; UvnasMoberg et al., 1994; Uvnas-Moberg, 1998a; da Silva Torres et al., 2003; Heinrichs et al., 2003; Onaka, 2004; Ribeiro et al., 2005).”
BackgroundThe Neurobiology of Social Affiliation and Pair Bonding
Carter, C. S., & Keverne, E. B. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00004-8 · Cited by 130
Effects of Skin-to-Skin Contact on Autonomic Pain Responses in Preterm Infants
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Breastfeeding and the mother–infant relationship—A review
JANSEN, J., de Weerth, C., & Riksen‐Walraven, J. M. (2008) · Developmental Review · doi:10.1016/j.dr.2008.07.001 · Cited by 126
“Specifically, the small peptide hormone oxytocin (OT) is released in a pulsatile fashion in response to suckling (Nissen et al., 1996; Ueda, Yokoyama, Irahara, & Aono, 1994, but see Uvnäs-Moberg, 1998, for a review).”
BackgroundLight, K. C., Smith, T. E., Johns, J. M., Brownley, K. A., Hofheimer, J. A., & Amico, J. A. (2000) · Health Psychology · doi:10.1037/0278-6133.19.6.560 · Cited by 154
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
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Leng, M., Liu, P., Zhang, P., Hu, M., Zhou, H., Li, G., Yin, H., & Chen, L. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.032 · Cited by 119
IJzerman, H., & Koole, S. L. (2011) · Psychological Bulletin · doi:10.1037/a0022373 · Cited by 123
A relationship between oxytocin and anxiety of romantic attachment
Marazziti (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-28 · Cited by 124
Effects of appraisal and coping on the neuroendocrine response to extreme stress
Olff, M., Langeland, W., & Gersons, B. P. R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.12.006 · Cited by 160
Use of Psychotropic Medications in Treating Mood Disorders during Lactation
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Dreisoerner, A., Junker, N. M., Schlotz, W., Heimrich, J., Bloemeke, S., Ditzen, B., & van Dick, R. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100091 · Cited by 118
Rault, J., van den Munkhof, M. H., & Buisman‐Pijlman, F. T. A. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01521 · Cited by 122
Barrett, C. E., Arambula, S. E., & Young, L. J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.73 · Cited by 115
The physiology and pharmacology of oxytocin in labor and in the peripartum period
Uvnäs-Moberg, K. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.04.011 · Cited by 118
Self-citationEapen, V., Dadds, M. R., Barnett, B. E. W., Kohlhoff, J. R., Khan, F., Radom, N., & Silove, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107745 · Cited by 123
Adult attachment representations predict cortisol and oxytocin responses to stress
Pierrehumbert, B., Torrisi, R., Ansermet, F., Borghini, A., & Halfon, O. (2012) · Attachment & Human Development · doi:10.1080/14616734.2012.706394 · Cited by 115
“OT is an hypothalamic neuropeptide implicated in the regulation of a variety of reproductive and social functions among humans and other mammals (Campbell, 2008; Carter, 2003; Carter, 1998; Feldman, Gordon, Schneiderman, Weisman, & Zagoory-Sharon, 2010; HoltLunstad, Birmingham, & Light, 2008; Uvnäs-Moberg, 1998; Wisme…”
BackgroundSocial interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants
Ruan, H., & Wu, C.-F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711127105 · Cited by 112
“However, the underlying molecular networks require further exploration (6).”
BackgroundDe Dreu, C. K. W. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.10.003 · Cited by 114
“Oxytocin interacts with the hypothalamic—pituitary—adrenal axis to attenuate stress responses (Uvnas-Moberg, 1998; Heinrichs et al., 2003; Kirsch et al., 2005; Neumann, 2008), with dopaminergic, reward processing circuits in the nucleus accumbens shell and in the ventral tegmental area (Skuse and…”
BackgroundPerkeybile, A. M., Griffin, L. L., & Bales, K. L. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00021 · Cited by 114
“Given that early exposure to OT has been demonstrated to alter social behavior and other systems later in life (Bales and Carter, 2003a,b) and touch stimulation causes the release of OT in adults (Uvnas-Moberg, 1998), it is very possible that the increased amount of total parental care received by offspring in this ex…”
Background
Metadata
- Authors
- Uvnäs-Moberg, K.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 23
- Issue
- 8
- Pages
- 819-835
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W1878549597
- Cited by
- 966
- References
- 76
- Citations by year
- 2026: 28 · 2025: 20 · 2024: 37 · 2023: 26 · 2022: 27 · 2021: 37 · 2020: 34 · 2019: 30 · 2018: 47 · 2017: 42 · 2016: 47 · 2015: 49 · 2014: 40 · 2013: 52 · 2012: 44
- FWCI
- 22.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, positive social interaction, social behavior, neuroendocrine mechanisms, anti-stress effects, blood pressure, cortisol, insulin, cholecystokinin, oxytocin antagonist, naloxone, endogenous opioids, alpha2-adrenoceptors, wound healing, health-promoting properties, hypnosis, meditation, complementary and alternative medicine
- MeSH terms
- Animals, Breast Feeding, Emotions, Female, Humans, Interpersonal Relations, Lactation, Male, Neurosecretory Systems, Object Attachment, Oxytocin, Parents
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