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Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins
Open accessAbstract
Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer 1a), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-terminal coiled-coil (CC) domain that mediates self-multimerization. CC-Homers form natural complexes that cross-link mGluRs and are enriched at the postsynaptic density. Homer 1a does not multimerize and blocks the association of mGluRs with CC-Homer complexes. These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties.
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Metadata
- Authors
- Xiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A., Lanahan, A. A., Wenthold, R. J., & Worley, P. F.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 21
- Issue
- 4
- Pages
- 707-716
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2062904839
- Cited by
- 647
- References
- 2
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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