Reelin Activates Src Family Tyrosine Kinases in Neurons

Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation

Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., & Herz, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80861-2 · Cited by 916

Reelin Is a Ligand for Lipoprotein Receptors

D'Arcangelo, G., Homayouni, R., Keshvara, L., Rice, D. S., Sheldon, M., & Curran, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80860-0 · Cited by 808

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205147200 · Cited by 623

Lipoprotein receptors in the nervous system

Herz, J., & Bock, H. H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135342 · Cited by 457

Proteins of the CNR Family Are Multiple Receptors for Reelin

Senzaki, K., Ogawa, M., & Yagi, T. (1999) · Cell · doi:10.1016/s0092-8674(00)81552-4 · Cited by 272

Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

Utsunomiya-Tate, N., Kubo, K.-I., Tate, S.-I., Kainosho, M., Katayama, E., Nakajima, K., & Mikoshiba, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160272497 · Cited by 131

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782

Trekking across the Brain: The Journey of Neuronal Migration

Ayala, R., Shu, T., & Tsai, L.-H. (2007) · Cell · doi:10.1016/j.cell.2006.12.021 · Cited by 620

Reelin, lipoprotein receptors and synaptic plasticity

Herz, J., & Chen, Y. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2009 · Cited by 524

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497

Guiding Neuronal Cell Migrations

Marin, O., Valiente, M., Ge, X., & Tsai, L.-H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001834 · Cited by 417

Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway

Niu, S., Renfro, A., Quattrocchi, C. C., Sheldon, M., & D'Arcangelo, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00819-5 · Cited by 375

Reelin modulates NMDA receptor activity in cortical neurons

Chen, Y., Beffert, U., Ertunc, M., Tang, T.-S., Kavalali, E. T., Bezprozvanny, I., & Herz, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1951-05.2005 · Cited by 299

The involvement of Reelin in neurodevelopmental disorders

Folsom, T. D., & Fatemi, S. H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.015 · Cited by 275

The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons

Niu, S., Yabut, O., & D'Arcangelo, G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1917-08.2008 · Cited by 266

Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth

Jossin, Y., & Goffinet, A. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00928-07 · Cited by 235

Reelin signaling directly affects radial glia morphology and biochemical maturation

Hartfuss, E., Förster, E., Bock, H. H., Hack, M. A., Leprince, P., Luque, J. M., Herz, J., Frotscher, M., & Götz, M. (2003) · Development · doi:10.1242/dev.00654 · Cited by 237

Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice

May, P., Rohlmann, A., Bock, H. H., Zurhove, K., Marth, J. D., Schomburg, E. D., Noebels, J. L., Beffert, U., Sweatt, J. D., Weeber, E. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8872-8883.2004 · Cited by 236

Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination

Bock, H. H., Jossin, Y., Liu, P., Förster, E., May, P., Goffinet, A. M., & Herz, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306416200 · Cited by 213

Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3

Chai, X., Förster, E., Zhao, S., Bock, H. H., & Frotscher, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2934-08.2009 · Cited by 202

Receptor Clustering Is Involved in Reelin Signaling

Strasser, V., Fasching, D., Hauser, C., Mayer, H., Bock, H. H., Hiesberger, T., Herz, J., Weeber, E. J., Sweatt, J. D., Pramatarova, A., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1378-1386.2004 · Cited by 193

Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus

Qiu, S., Zhao, L. F., Korwek, K. M., & Weeber, E. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2561-06.2006 · Cited by 186

Regulation of Protein Tyrosine Kinase Signaling by Substrate Degradation during Brain Development

Arnaud, L., Ballif, B. A., & Cooper, J. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9293-9302.2003 · Cited by 164

Role for Reelin in stabilizing cortical architecture

Frotscher, M. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.06.001 · Cited by 157

Reelin signaling antagonizes β-amyloid at the synapse

Durakoglugil, M. S., Chen, Y., White, C. L., Kavalali, E. T., & Herz, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908176106 · Cited by 153

New insights into Reelin-mediated signaling pathways

Lee, G. H., & D’Arcangelo, G. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00122 · Cited by 144

Disabled-1-Regulated Adhesion of Migrating Neurons to Radial Glial Fiber Contributes to Neuronal Positioning during Early Corticogenesis

Sanada, K., Gupta, A., & Tsai, L.-H. (2004) · Neuron · doi:10.1016/s0896-6273(04)00222-3 · Cited by 149

Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development

Feng, L., Allen, N. S., Simo, S., & Cooper, J. A. (2007) · Genes & Development · doi:10.1101/gad.1604207 · Cited by 148

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice

Johnson, E. B., Hammer, R. E., & Herz, J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi381 · Cited by 141

Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase

May, P., Bock, H. H., Nimpf, J., & Herz, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305858200 · Cited by 142

Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission

Bal, M., Leitz, J., Reese, A. L., Ramirez, D. M. O., Durakoglugil, M., Herz, J., Monteggia, L. M., & Kavalali, E. T. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.024 · Cited by 131

Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro

Sinagra, M., Verrier, D., Frankova, D., Korwek, K. M., Blahos, J., Weeber, E. J., Manzoni, O. J., & Chavis, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1757-05.2005 · Cited by 128

Emerging topics in Reelin function

Förster, E., Bock, H. H., Herz, J., Chai, X., Frotscher, M., & Zhao, S. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07222.x · Cited by 130

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

Marzolo, M.-P., & Bu, G. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.10.005 · Cited by 122

Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity

Beffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E., & Herz, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4566-05.2006 · Cited by 121

Reelin in the years: controlling neuronal migration and maturation in the mammalian brain

D'Arcangelo, G. (2014) · Advances in Neuroscience · doi:10.1155/2014/597395 · Cited by 120

Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes

Stolt, P. C., Jeon, H., Song, H. K., Herz, J., Eck, M. J., & Blacklow, S. C. (2003) · Structure · doi:10.1016/s0969-2126(03)00068-6 · Cited by 117

Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development

Andersen, O. M., Yeung, C.-H., Vorum, H., Wellner, M., Andreassen, T. K., Erdmann, B., Mueller, E.-C., Herz, J., Otto, A., Cooper, T. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302157200 · Cited by 112

Multiple pathways of apolipoprotein E signaling in primary neurons

Hoe, H., Harris, D. C., & Rebeck, G. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03007.x · Cited by 111

Functional Roles of the Interaction of APP and Lipoprotein Receptors

Pohlkamp, T., Wasser, C. R., & Herz, J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00054 · Cited by 92

Canonical and non-canonical Reelin signaling

Bock, H. H., & May, P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00166 · Cited by 107

Apolipoprotein E Receptors Are Required for Reelin-induced Proteasomal Degradation of the Neuronal Adaptor Protein Disabled-1

Bock, H. H., Jossin, Y., May, P., Bergner, O., & Herz, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401770200 · Cited by 102

Clusterin Is a Ligand for Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR) and Signals via the Reelin-signaling Pathway

Leeb, C., Eresheim, C., & Nimpf, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529271 · Cited by 99

Reelin protects against amyloid β toxicity in vivo

Lane-Donovan, C., Philips, G. T., Wasser, C. R., Durakoglugil, M. S., Masiulis, I., Upadhaya, A., Pohlkamp, T., Coskun, C., Kotti, T., Steller, L., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aaa6674 · Cited by 96

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

Lane-Donovan, C., & Herz, J. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075507 · Cited by 94

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

Matsuki, T., Pramatarova, A., & Howell, B. W. (2008) · Journal of Cell Science · doi:10.1242/jcs.027334 · Cited by 92

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-d-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Nakajima, C., Kulik, A., Frotscher, M., Herz, J., Schäfer, M., Bock, H. H., & May, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444364 · Cited by 85

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

Knuesel, I. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.002 · Cited by 89

ApoE isoform-dependent changes in hippocampal synaptic function

Korwek, K. M., Trotter, J. H., LaDu, M. J., Sullivan, P. M., & Weeber, E. J. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-21 · Cited by 89

The Extremely Conserved C-terminal Region of Reelin Is Not Necessary for Secretion but Is Required for Efficient Activation of Downstream Signaling

Nakano, Y., Kohno, T., Hibi, T., Kohno, S., Baba, A., Mikoshiba, K., Nakajima, K., & Hattori, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702300200 · Cited by 86

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

Leemhuis, J., Bouché, E., Frotscher, M., Henle, F., Hein, L., Herz, J., Meyer, D. K., Pichler, M., Roth, G., Schwan, C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4036-10.2010 · Cited by 80

ApoE receptor 2 controls neuronal survival in the adult brain

Beffert, U., Nematollah Farsian, F., Masiulis, I., Hammer, R. E., Yoon, S. O., Giehl, K. M., & Herz, J. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.029 · Cited by 84

Role for Reelin in neurotransmitter release

Hellwig, S., Hack, I., Kowalski, J., Brunne, B., Jarowyj, J., Unger, A., Bock, H. H., Junghans, D., & Frotscher, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-10.2011 · Cited by 74

LDL Receptor‐Related Proteins in Neurodevelopment

May, P., & Herz, J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00086_4_5.x · Cited by 60

The Reelin Receptors Apoer2 and Vldlr Coordinate the Patterning of Purkinje Cell Topography in the Developing Mouse Cerebellum

Larouche, M., Beffert, U., Herz, J., & Hawkes, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001653 · Cited by 49

Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons.

Hoe, H.-S., Freeman, J., & Rebeck, G. W. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-18 · Cited by 45

Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease

Yi, L. X., Zeng, L., Wang, Q., Tan, E. K., & Zhou, Z. D. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102339 · Cited by 41

Reconstitution of the Reelin Signaling Pathway in Fibroblasts Demonstrates that Dab1 Phosphorylation Is Independent of Receptor Localization in Lipid Rafts

Mayer, H., Duit, S., Hauser, C., Schneider, W. J., & Nimpf, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.19-27.2006 · Cited by 39

Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis

Bracher-Smith, M., Leonenko, G., Baker, E., Crawford, K., Graham, A. C., Salih, D. A., Howell, B. W., Hardy, J., & Escott-Price, V. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.07.009 · Cited by 31

Effects of apoE on neuronal signaling and APP processing in rodent brain

Hoe, H.-S., Pocivavsek, A., Dai, H., Chakraborty, G., Harris, D. C., & Rebeck, G. W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.035 · Cited by 30

Reciprocal Regulation of Very Low Density Lipoprotein Receptors (VLDLRs) in Neurons by Brain-derived Neurotrophic Factor (BDNF) and Reelin

Do, H. T., Bruelle, C., Tselykh, T., Jalonen, P., Korhonen, L., & Lindholm, D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.500967 · Cited by 20

High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons

Herrick, T. M., & Cooper, J. A. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.03.022 · Cited by 19

Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway

Larios, J. A., Jausoro, I., Benitez, M.-L., Bronfman, F. C., & Marzolo, M.-P. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-108 · Cited by 12

Novel aspects of the apolipoprotein-E receptor family: regulation and functional role of their proteolytic processing

Larios, J. A., & Marzolo, M.-P. (2012) · Frontiers in Biology · doi:10.1007/s11515-011-1186-7 · Cited by 9