LDL Receptor‐Related Proteins in Neurodevelopment

May, Petra; Herz, Joachim

doi:10.1034/j.1600-0854.2003.00086_4_5.x

Cited by 60

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

LDL Receptor‐Related Proteins in Neurodevelopment

May, Petra, Herz, Joachim·2003·Traffic

DOI 10.1034/j.1600-0854.2003.00086_4_5.x

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Abstract

Low‐density lipoprotein receptor‐related proteins (LRPs) are evolutionarily ancient cell‐surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family. Here, we will summarize recent advances in our understanding of the molecular basis on which these receptors function during development.

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9 of 9 references verified0 citation errors · 0 not checkable

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All members of the LDLR family and more distantly related receptors contain at least one YWTD-motif-containing beta-propeller domain with flanking EGF-like cysteine-rich repeats.
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Other than the presence of disulfide bonds, no common structural feature of gp96 clients has emerged.
“Other than the presence of disulfide bonds, no common structural feature of gp96 clients has emerged.12”
From Proteomic Plasma Membrane Profiling Reveals an Essential Role for gp96 in the Cell Surface Expression of LDLR Family Members, Including the LDL Receptor and LRP6 (2012) · cites this paper as [12]

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Background
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The cell biology of neurogenesis
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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
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LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction
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Self-citation
Proteomic Plasma Membrane Profiling Reveals an Essential Role for gp96 in the Cell Surface Expression of LDLR Family Members, Including the LDL Receptor and LRP6
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ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity
Fuentealba, R. A., Barría, M. I., Lee, J., Cam, J., Araya, C., Escudero, C. A., Inestrosa, N. C., Bronfman, F. C., Bu, G., & Marzolo, M.-P. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-14 · Cited by 70

Authors: May, P., & Herz, J.
Venue: Traffic
Publisher: Wiley
Published: 2003-05
Volume: 4
Issue: 5
Pages: 291-301
ISSN: 1398-9219
1600-0854
DOI: 10.1034/j.1600-0854.2003.00086_4_5.x
Cited by: 60
References: 9
Language: en
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2331 d)

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LDL Receptor‐Related Proteins in Neurodevelopment

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