CoChat
Sign Up
Cited by 257

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study

Shaw, Philip, Lerch, Jason P, Pruessner, Jens C, Taylor, Kristin N, Rose, A Blythe, Greenstein, Deanna, Clasen, Liv, Evans, Alan, Rapoport, Judith L, Giedd, Jay N·2007·The Lancet Neurology
DOI 10.1016/s1474-4422(07)70106-0
Open this paper in CoChat — free account

Abstract

Background Alleles of the apolipoprotein E (APOE) gene modulate risk for Alzheimer's disease, with carriers of the epsilon4 allele being at increased risk and carriers of the epsilon2 allele possibly at decreased risk compared with non-carriers. Our aim was to determine whether possession of an epsilon4 allele would confer children with a neural substrate that might render them at risk for Alzheimer's disease, and whether carriers of the epsilon2 allele might have a so-called protective cortical morphology. Methods 239 healthy children and adolescents were genotyped and had repeated neuroanatomic MRI (total 530 scans). Mixed model regression was used to determine whether the developmental trajectory of the cortex differed by genotype. Findings Cortical thickness of the left entorhinal region was significantly thinner in epsilon4 carriers than it was in non-epsilon4 carriers (3.79 [SE 0.06] mm, range 1.54-5.24 vs 3.94 [0.03] mm, 2.37-6.11; p=0.03). There was a significant stepwise increase in cortical thickness in the left entorhinal regions, with epsilon4 carriers having the thinnest cortex and epsilon2 carriers the thickest, with epsilon3 homozygotes occupying an intermediate position (left beta 0.11 [SE 0.05], p=0.02). Neuroanatomic effects seemed fixed and non-progressive, with no evidence of accelerated cortical loss in young healthy epsilon4 carriers. Interpretation Alleles of the apolipoprotein E gene have distinct neuroanatomic signatures, identifiable in childhood. Th…

Overview

Integrity signals

Registry

Crossref · 10.1016/s1474-4422(07)70106-0

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 48

  1. Braak, 1996, Pattern of brain destruction in Parkinson's and Alzheimer's diseases, J Neural Transm, 103, 455, 10.1007/BF01276421 · DOI
  2. Krasuski, 1998, Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls), Biol Psychiatry, 43, 60, 10.1016/S0006-3223(97)00013-9 · DOI
  3. Callen, 2001, Beyond the hippocampus: MRI volumetry confirms widespread limbic atrophy in AD, Neurology, 57, 1669, 10.1212/WNL.57.9.1669 · DOI
  4. Xu, 2000, Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD, Neurology, 54, 1760, 10.1212/WNL.54.9.1760 · DOI
  5. Juottonen, 1999, Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease, AJNR Am J Neuroradiol, 20, 139
  6. Thompson, 2004, Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia, Neuroimage, 23, S2, 10.1016/j.neuroimage.2004.07.071 · DOI
  7. Lerch, 2005, Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy, Cerebral Cortex, 15, 995, 10.1093/cercor/bhh200 · DOI
  8. Scahill, 2002, Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI, Proc Natl Acad Sci USA, 99, 4703, 10.1073/pnas.052587399 · DOI
  9. de Leon, 2001, Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET), Proc Natl Acad Sci USA, 98, 10966, 10.1073/pnas.191044198 · DOI · Paper page
  10. deToledo-Morrell, 2004, MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD, Neurobiol Aging, 25, 1197, 10.1016/j.neurobiolaging.2003.12.007 · DOI
  11. Corder, 1993, Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, 261, 921, 10.1126/science.8346443 · DOI · Paper page
  12. Scarmeas, 2004, APOE-dependent PET patterns of brain activation in Alzheimer disease, Neurology, 63, 913, 10.1212/01.WNL.0000137274.93125.46 · DOI
  13. Smith, 2002, Women at risk for AD show increased parietal activation during a fluency task, Neurology, 58, 1197, 10.1212/WNL.58.8.1197 · DOI
  14. Small, 2000, Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease, Proc Natl Acad Sci USA, 97, 6037, 10.1073/pnas.090106797 · DOI · Paper page
  15. Reiman, 2005, Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism, Proc Natl Acad Sci USA, 102, 8299, 10.1073/pnas.0500579102 · DOI · Paper page
  16. Teter, 2002, Neuroplasticity in Alzheimer's disease, J Neurosci Res, 70, 402, 10.1002/jnr.10441 · DOI · Paper page
  17. Buttini, 1999, Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration, J Neurosci, 19, 4867, 10.1523/JNEUROSCI.19-12-04867.1999 · DOI
  18. Teasdale, 2005, The association between APOE epsilon4, age and outcome after head injury: a prospective cohort study, Brain, 128, 2556, 10.1093/brain/awh595 · DOI
  19. Blackman, 2005, Apolipoprotein E and brain injury: Implications for children, Dev Med Child Neurol, 47, 64, 10.1111/j.1469-8749.2005.tb01042.x · DOI
  20. Ganguli, 2000, Apolipoprotein E Polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study, Arch Neurol, 57, 824, 10.1001/archneur.57.6.824 · DOI
  21. Katzman, 1997, Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia, Neurology, 49, 779, 10.1212/WNL.49.3.779 · DOI
  22. Qiu, 2004, Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex, J Neurol Neurosurg Psychiatry, 75, 828, 10.1136/jnnp.2003.021493 · DOI
  23. Wilson, 2002, The apolipoprotein E {varepsilon}2 allele and decline in episodic memory, J Neurol Neurosurg Psychiatry, 73, 672, 10.1136/jnnp.73.6.672 · DOI · Paper page
  24. Van Hoesen, 2000, Orbitofrontal cortex pathology in Alzheimer's disease, Cereb Cortex, 10, 243, 10.1093/cercor/10.3.243 · DOI
  25. Giedd, 1996, Quantitative magnetic resonance imaging of human brain development: ages 4–18, Cereb Cortex, 6, 551, 10.1093/cercor/6.4.551 · DOI · Paper page
  26. Sled, 1998, A nonparametric method for automatic correction of intensity nonuniformity in MRI data, IEEE Trans Med Imag, 17, 87, 10.1109/42.668698 · DOI · Paper page
  27. Zijdenbos, 2002, Automatic “pipeline” analysis of 3-D MRI data for clinical trials: application to multiple sclerosis, IEEE Trans Med Imag, 21, 1280, 10.1109/TMI.2002.806283 · DOI
  28. MacDonald, 2000, Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI, Neuroimage, 12, 340, 10.1006/nimg.1999.0534 · DOI
  29. Kim, 2005, Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification, Neuroimage, 27, 210, 10.1016/j.neuroimage.2005.03.036 · DOI
  30. Lerch, 2005, Cortical thickness analysis examined through power analysis and a population simulation, Neuroimage, 24, 163, 10.1016/j.neuroimage.2004.07.045 · DOI
  31. Pruessner, 2002, Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus, Cereb Cortex, 12, 1342, 10.1093/cercor/12.12.1342 · DOI · Paper page
  32. Collins, 1995, Automatic 3-D model-based neuroanatomical segmentation, Human Brain Mapping, 3, 190, 10.1002/hbm.460030304 · DOI
  33. Benjamini, 1995, Controlling the false discovery rate: a practical and powerful approach to multiple testing, J R Stat Soc Ser B, 57, 289, 10.1111/j.2517-6161.1995.tb02031.x · DOI · Paper page
  34. Genovese, 2002, Thresholding of statistical maps in functional neuroimaging using the false discovery rate, Neuroimage, 15, 870, 10.1006/nimg.2001.1037 · DOI · Paper page
  35. Ongur, 2003, Architectonic subdivision of the human orbital and medial prefrontal cortex, J Comp Neurol, 460, 425, 10.1002/cne.10609 · DOI · Paper page
  36. Sowell, 2004, Longitudinal mapping of cortical thickness and brain growth in normal children, J Neurosci, 24, 8223, 10.1523/JNEUROSCI.1798-04.2004 · DOI · Paper page
  37. Huttenlocher, 1997, Regional differences in synaptogenesis in human cerebral cortex, J Comp Neurol, 387, 167, 10.1002/(SICI)1096-9861(19971020)387:2<167::AID-CNE1>3.0.CO;2-Z · DOI
  38. Grignon, 1998, Cytoarchitectonic alterations in the supramarginal gyrus of late onset Alzheimer's disease, Acta Neuropathol (Berl), 95, 395, 10.1007/s004010050816 · DOI
  39. Kabani, 2001, Measurement of cortical thickness using an automated 3-D algorithm: a validation study, Neuroimage, 13, 375, 10.1006/nimg.2000.0652 · DOI · Paper page
  40. Turic, 2001, No association between apolipoprotein E polymorphisms and general cognitive ability in children, Neurosci Lett, 299, 97, 10.1016/S0304-3940(00)01789-4 · DOI
  41. Small, 2004, Apolipoprotein E and cognitive performance: a meta-analysis, Psychol Aging, 19, 592, 10.1037/0882-7974.19.4.592 · DOI · Paper page
  42. Deary, 2003, The influence of the epsilon 4 allele of the apolipoprotein E gene on childhood IQ, nonverbal reasoning in old age, and lifetime cognitive change, Intelligence, 31, 85, 10.1016/S0160-2896(02)00114-9 · DOI
  43. Becher, 2006, The distribution of apolipoprotein E alleles in Scottish perinatal deaths, J Med Genet, 43, 414, 10.1136/jmg.2005.033936 · DOI
  44. Oria, 2005, APOE4 protects the cognitive development in children with heavy diarrhea burdens in northeast Brazil, Pediatr Res, 57, 310, 10.1203/01.PDR.0000148719.82468.CA · DOI
  45. Lee, 2002, Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site, Peptides, 23, 1249, 10.1016/S0196-9781(02)00060-8 · DOI
  46. Pedersen, 2000, A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal, J Neurochem, 74, 1426, 10.1046/j.1471-4159.2000.0741426.x · DOI
  47. Lee, 2006, A novel quantitative cross-validation of different cortical surface reconstruction algorithms using MRI phantom, Neuroimage, 31, 572, 10.1016/j.neuroimage.2005.12.044 · DOI · Paper page
  48. MacDonald, 2000, Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI, Neuroimage, 12, 340, 10.1006/nimg.1999.0534 · DOI

Cited by

Sorted by citations

Metadata

Authors
Shaw, P., Lerch, J. P., Pruessner, J. C., Taylor, K. N., Rose, A. B., Greenstein, D., Clasen, L., Evans, A., Rapoport, J. L., & Giedd, J. N.
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2007-06
Volume
6
Issue
6
Pages
494-500
ISSN
1474-4422
DOI
10.1016/s1474-4422(07)70106-0
Cited by
257
References
7
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review