Obstructive sleep apnoea and type 2 diabetes mellitus: a bidirectional association
Abstract
Obstructive sleep apnoea and type 2 diabetes are common medical disorders that have important clinical, epidemiological, and public health implications. Research done in the past two decades indicates that obstructive sleep apnoea, through the effects of intermittent hypoxaemia and sleep fragmentation, could contribute independently to the development of insulin resistance, glucose intolerance, and type 2 diabetes. Conversely, type 2 diabetes might increase predisposition to, or accelerate progression of, obstructive and central sleep apnoea, possibly through the development of peripheral neuropathy and abnormalities of ventilatory and upper airway neural control. Although more research is needed to clarify the mechanisms underlying the bidirectional association between the two disorders, their frequent coexistence should prompt all health-care professionals to embrace clinical practices that include screening of a patient presenting with one disorder for the other. Early identification of obstructive sleep apnoea in patients with metabolic dysfunction, including type 2 diabetes, and assessment for metabolic abnormalities in those with obstructive sleep apnoea could reduce cardiovascular disease risk and improve the quality of life of patients with these chronic diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The association between OSA severity and glucose variability is thought to be mediated by sympathetic overactivation.
“is thought to be mediated by sympathetic overactivation (21).”
From Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young (2026) · cites this paper as [21]
Cites
1 retracted
RETRACTED: CPAP for the Metabolic Syndrome in Patients with Obstructive Sleep Apnea
Sharma, S. K., Agrawal, S., Damodaran, D., Sreenivas, V., Kadhiravan, T., Ramakrishnan, L., Jagia, P., & Kumar, A. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103944 · Cited by 367 · see citing works
RetractedDiagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118 · see citing works
Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A. L., Tsapas, A., Wender, R., & Matthews, D. R. (2012) · Diabetologia · doi:10.1007/s00125-012-2534-0 · Cited by 3,919 · see citing works
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668 · see citing works
Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine, Epstein, L. J., Kristo, D., Strollo, P. J., Friedman, N., Malhotra, A., Patil, S. P., Ramar, K., Rogers, R., Schwab, R. J., et al. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27497 · Cited by 3,360 · see citing works
Diagnosis and Classification of diabetes mellitus
Rossi, G. (2014) · Diapedia.org eBooks · doi:10.14496/dia..20 · Cited by 3,212 · see citing works
Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach
Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A. L., Tsapas, A., Wender, R., & Matthews, D. R. (2012) · Diabetes Care · doi:10.2337/dc12-0413 · Cited by 3,207 · see citing works
Reilly, J. J., & Kelly, J. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.222 · Cited by 2,280 · see citing works
Longitudinal Study of Moderate Weight Change and Sleep-Disordered Breathing
Peppard, P. E. (2000) · JAMA · doi:10.1001/jama.284.23.3015 · Cited by 2,020 · see citing works
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn387 · Cited by 1,410 · see citing works
Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes
Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175 · see citing works
Punjabi, N. M. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh261 · Cited by 1,107 · see citing works
Self-citationAssociation of sleep time with diabetes mellitus and impaired glucose tolerance
Gottlieb, D. J., Punjabi, N. M., Newman, A. B., Resnick, H. E., Redline, S., Baldwin, C. M., & Nieto, F. J. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.8.863 · Cited by 927 · see citing works
Self-citationSlow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921 · see citing works
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857 · see citing works
Inzucchi, S., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M. A., Peters, A. L., Τσάπας, Α., Wender, R. C., & Dr, M. (2013) · Diabetes Care · doi:10.2337/dc13-er02 · Cited by 805 · see citing works
Association of Sleep Apnea and Type II Diabetes
Reichmuth, K. J., Austin, D., Skatrud, J. B., & Young, T. B. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-637oc · Cited by 770 · see citing works
Physical Activity of Moderate Intensity and Risk of Type 2 Diabetes
Jeon, C. Y., Lokken, R. P., Hu, F. B., & van Dam, R. M. (2007) · Diabetes Care · doi:10.2337/dc06-1842 · Cited by 758 · see citing works
A family of tissue-specific resistin-like molecules
Steppan, C. M., Brown, E. J., Wright, C. M., Bhat, S., Banerjee, R. R., Dai, C. Y., Enders, G. H., Silberg, D. G., Wen, X., Wu, G. D., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.502 · Cited by 635 · see citing works
Effects of Sleep Fragmentation on Glucose Metabolism in Normal Subjects
Stamatakis, K. A., & Punjabi, N. M. (2010) · Chest · doi:10.1378/chest.09-0791 · Cited by 614 · see citing works
Self-citationObstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes
Foster, G. D., Sanders, M. H., Millman, R., Zammit, G., Borradaile, K. E., Newman, A. B., Wadden, T. A., Kelley, D., Wing, R. R., Pi Sunyer, F. X., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1776 · Cited by 600 · see citing works
Leptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works
Foster, G. D. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.266 · Cited by 538 · see citing works
Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans
Somers, V. K., Mark, A. L., Zavala, D. C., & Abboud, F. M. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.5.2101 · Cited by 530 · see citing works
Rajala, M. W., Obici, S., Scherer, P. E., & Rossetti, L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16521 · Cited by 525 · see citing works
Diabetes and Sleep Disturbances
Resnick, H. E., Redline, S., Shahar, E., Gilpin, A., Newman, A., Walter, R., Ewy, G. A., Howard, B. V., & Punjabi, N. M. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.702 · Cited by 504 · see citing works
Self-citationImpact of untreated obstructive sleep apnea on glucose control in type 2 diabetes
Aronsohn, R. S., Whitmore, H., Van Cauter, E., & Tasali, E. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200909-1423oc · Cited by 453 · see citing works
Lifestyle Intervention with Weight Reduction: First-line Treatment in Mild Obstructive Sleep Apnea
Tuomilehto, H., Seppä, J., Partinen, M., Peltonen, M., Gylling, H., Tuomilehto, J., Vanninen, E. J., Kokkarinen, J. I., Sahlman, J., Martikainen, T., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200805-669oc · Cited by 438 · see citing works
Intermittent Hypoxia Increases Insulin Resistance in Genetically Obese Mice
Polotsky, V. Y., Li, J., Punjabi, N. M., Rubin, A. E., Smith, P. L., Schwartz, A. R., & O'Donnell, C. P. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.048173 · Cited by 375 · see citing works
Self-citationDisorders of glucose metabolism in sleep apnea
Punjabi, N. M., & Polotsky, V. Y. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00695.2005 · Cited by 373 · see citing works
Self-citationPrevalence of obstructive sleep apnoea in men with type 2 diabetes
West, S. D., Nicoll, D., & Stradling, J. R. (2006) · Thorax · doi:10.1136/thx.2005.057745 · Cited by 372 · see citing works
Hedner, J. A., Ejnell, H., Sellgren, J., Hedner, T., & Wallin, G. B. (1988) · Journal of Hypertension · doi:10.1097/00004872-198812040-00166 · Cited by 366 · see citing works
Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans
Somers, V. K., Mark, A. L., Zavala, D. C., & Abboud, F. M. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.5.2095 · Cited by 365 · see citing works
Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers.
Louis, M., & Punjabi, N. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91523.2008 · Cited by 342 · see citing works
Self-citationSleep disturbance is associated with cardiovascular and metabolic disorders
Grandner, M. A., JACKSON, N. J., Pak, V. M., & Gehrman, P. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2011.00990.x · Cited by 338 · see citing works
Snoring as a Risk Factor for Type II Diabetes Mellitus: A Prospective Study
Al‐Delaimy, W. K., Manson, J. E., Willett, W. C., Stampfer, M. J., & Hu, F. B. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.5.387 · Cited by 328 · see citing works
Brooks, B. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.6.1681 · Cited by 295 · see citing works
Johansson, K., Neovius, M., Lagerros, Y. T., Harlid, R., Rössner, S., Granath, F. N., & Hemmingsson, E. (2009) · BMJ · doi:10.1136/bmj.b4609 · Cited by 293 · see citing works
Sleep‐disordered breathing and glucose metabolism in hypertensive men: a population‐based study
Elmasry, A., Lindberg, E., Berne, C., Janson, C., Gíslason, Þ., Tageldin, M. A., & Boman, G. (2001) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2001.00787.x · Cited by 286 · see citing works
Leal, V. D. O., & Mafra, D. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.02.003 · Cited by 275 · see citing works
Adiponectin: Regulation of its production and its role in human diseases
Shehzad, A., Iqbal, W., Shehzad, O., & Lee, Y. S. (2012) · HORMONES · doi:10.1007/bf03401534 · Cited by 272 · see citing works
Prevalence of Sleep Apnea in a Population of Adults with Type 2 Diabetes Mellitus
Einhorn, D., Stewart, D. A., Erman, M. K., Gordon, N., Philis-Tsimikas, A., & Casal, E. (2007) · Endocrine Practice · doi:10.4158/ep.13.4.355 · Cited by 232 · see citing works
Obstructive Sleep Apnea and Type 2 Diabetes: Is There a Link?
Pamidi, S., & Tasali, E. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00126 · Cited by 231 · see citing works
Sleep-disordered breathing, glucose intolerance, and insulin resistance
Punjabi, N. M., Ahmed, M. M., Polotsky, V. Y., Beamer, B. A., & O'Donnell, C. P. (2003) · Respiratory Physiology & Neurobiology · doi:10.1016/s1569-9048(03)00079-x · Cited by 228 · see citing works
Self-citationHypoxia Causes Glucose Intolerance in Humans
Oltmanns, K. M., Gehring, H., Rudolf, S., Schultes, B., Rook, S., Schweiger, U., Jan Born, A., Fehm, H. L., & Peters, A. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200308-1200oc · Cited by 215 · see citing works
The effect of altitude hypoxia on glucose homeostasis in men
Larsen, J. J., Hansen, J. M., Olsen, N. V., Galbo, H., & Dela, F. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.241bf.x · Cited by 205 · see citing works
Marshall, N. S., WONG, K. K. H., Phillips, C. L., Liu, P. Y., Knuiman, M. W., & Grunstein, R. R. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27387 · Cited by 198 · see citing works
Weinstock, T. G., Wang, X., Rueschman, M., Ismail-Beigi, F., Aylor, J., Babineau, D. C., Mehra, R., & Redline, S. (2012) · Sleep · doi:10.5665/sleep.1816 · Cited by 181 · see citing works
Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans
Utzschneider, K. M., Carr, D. B., Tong, J., Wallace, T. M., Hull, R. L., Zraika, S., Xiao, Q., Mistry, J., Retzlaff, B. M., Knopp, R. H., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1932-y · Cited by 173 · see citing works
Role of leptin in the pancreatic β-cell: effects and signaling pathways
Marroquí, L., González, A., Ñeco, P., Caballero‐Garrido, E., Vieira, E. C., Ripoll, C., Nadal, Á., & Quesada, I. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0025 · Cited by 151 · see citing works
Loredo, J. S., Ziegler, M. G., Ancoli‐Israel, S., Clausen, J. L., & Dimsdale, J. E. (1999) · CHEST Journal · doi:10.1378/chest.116.3.655 · Cited by 141 · see citing works
Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea
Lavie, L. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e469 · Cited by 139 · see citing works
Obstructive sleep apnoea and diabetes mellitus: the role of cardiovascular autonomic neuropathy
Ficker, J. H., Dertinger, S., Siegfried, W., König, H. J., Pentz, M., Sailer, D., Katalinic, A., & Hahn, E. G. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.11010014 · Cited by 136 · see citing works
Role of obstructive sleep apnea in cardiovascular disease
Monahan, K., & Redline, S. S. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834b806a · Cited by 133 · see citing works
Prevalence of sleep apnoea in diabetic patients
Schober, A.-K., Neurath, M. F., & Harsch, I. A. (2010) · The Clinical Respiratory Journal · doi:10.1111/j.1752-699x.2010.00216.x · Cited by 123 · see citing works
Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea
Lavie, L. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/469 · Cited by 118 · see citing works
Yang, D., Liu, Z., Yang, H., & Luo, Q. (2012) · Sleep And Breathing · doi:10.1007/s11325-012-0680-8 · Cited by 114 · see citing works
Lou, P., Chen, P., Zhang, L., Zhang, P., Yu, J., Zhang, N., Wu, H., & Zhao, J. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-000956 · Cited by 106 · see citing works
Prevalence of Diagnosed Sleep Apnea Among Patients With Type 2 Diabetes in Primary Care
Heffner, J. E., Rozenfeld, Y., Kai, M., Stephens, E., & Brown, L. K. (2011) · CHEST Journal · doi:10.1378/chest.11-1945 · Cited by 103 · see citing works
Dernaika, T. A., Kinasewitz, G. T., & Tawk, M. M. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27435 · Cited by 102 · see citing works
Thomasouli, M.-A., Brady, E. M., Davies, M. J., Hall, A. P., Khunti, K. K., Morris, D. H., & Gray, L. J. (2013) · Sleep And Breathing · doi:10.1007/s11325-013-0806-7 · Cited by 101 · see citing works
The predictors of central and obstructive sleep apnoea in haemodialysis patients.
Tada, T., Kusano, K., Ogawa, A., Iwasaki, J., Sakuragi, S., Kusano, I., Takatsu, S., Miyazaki, M., & Ohe, T. (2007) · Nephrology, Dialysis and Transplantation · doi:10.1093/ndt/gfl748 · Cited by 101 · see citing works
Braun, B., Rock, P. B., Zamudio, S., Wolfel, G. E., Mazzeo, R. S., Muza, S. R., Fulco, C. S., MOORE, L. G., & Butterfield, G. E. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.623 · Cited by 101 · see citing works
Tuomilehto, H., Gylling, H., Peltonen, M., Martikainen, T., Sahlman, J., Kokkarinen, J. I., Randell, J. T., Tukiainen, H. O., Vanninen, E. J., Partinen, M., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29485 · Cited by 100 · see citing works
Clinical Manifestations and Current Treatment options for Diabetic Neuropathies
CASELLINI, C. M., & Vinik, A. I. (2007) · Endocrine Practice · doi:10.4158/ep.13.5.550 · Cited by 92 · see citing works
Sleep-disordered breathing in nonobese diabetic subjects with autonomic neuropathy
Bottini, P., Dottorini, M., Cordoni, M. C., Casucci, G., & Tantucci, C. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00070402 · Cited by 85 · see citing works
Plasma Levels of Adiponectin, a Novel Adipocyte‐Derived Hormone, in Sleep Apnea**
Wolk, R. A., Svatikova, A., Nelson, C. A., Gami, A. S., Govender, K., Winnicki, M., & Somers, V. K. (2005) · Obesity Research · doi:10.1038/oby.2005.24 · Cited by 84 · see citing works
Economic impact of childhood obesity on health systems: a systematic review
Pelone, F., Specchia, M. L., Veneziano, M. A., Capizzi, S., Bucci, S., Mancuso, A., Ricciardi, W., & de Belvis, A. G. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00968.x · Cited by 80 · see citing works
Serum Adiponectin Levels in Adult Male Patients with Obstructive Sleep Apnea Hypopnea Syndrome
Zhang, X., Yin, K., Wang, H., & Su, S. (2005) · Respiration · doi:10.1159/000088690 · Cited by 80 · see citing works
Effect of Hypoxia on Blood Glucose, Hormones, and Insulin Receptor Functions in Newborn Calves
Cheng, N., Cai, W., Jiang, M., & Wu, S. (1997) · Pediatric Research · doi:10.1203/00006450-199706000-00009 · Cited by 77 · see citing works
Sleep Apnoea in Diabetic Patients with Autonomic Neuropathy
Rees, P. J., Prior, J. G., Cochrane, G. M., & Clark, T. J. H. (1981) · Journal of the Royal Society of Medicine · doi:10.1177/014107688107400306 · Cited by 76 · see citing works
Autonomic Neuropathy Increases the Risk of Obstructive Sleep Apnea in Obese Diabetics
Bottini, P., Redolfi, S., Dottorini, M. L., & Tantucci, C. (2007) · Respiration · doi:10.1159/000100556 · Cited by 73 · see citing works
Reduced levels of adiponectin in sleep apnea syndrome
Masserini, B., Morpurgo, P. S., Donadio, F., Baldessari, C., Bossi, R., Beck‐Peccoz, P., & Orsi, E. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344179 · Cited by 67 · see citing works
Epinephrine inhibits insulin-mediated glycogenesis but enhances glycolysis in human skeletal muscle
Raz, I., Katz, A., & SPENCER, M. K. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.3.e430 · Cited by 65 · see citing works
Cardiovascular Consequences of Sleep Apnea
Golbidi, S., Badran, M., Ayas, N., & Laher, I. (2011) · Lung · doi:10.1007/s00408-011-9340-1 · Cited by 62 · see citing works
Tantucci, C., Scionti, L., Bottini, P., Dottorini, M. L., Puxeddu, E., Casucci, G., & Sorbini, C. A. (1997) · CHEST Journal · doi:10.1378/chest.112.1.145 · Cited by 62 · see citing works
Do Sleep Disorders and Associated Treatments Impact Glucose Metabolism?
Punjabi, N. M. (2009) · Drugs · doi:10.2165/11531150-000000000-00000 · Cited by 59 · see citing works
Self-citationHecht, L., Mohler, R. A., & Meyer, G. (2011) · PubMed Central · doi:10.3205/000143 · Cited by 58 · see citing works
The Effect of Hypoxia on Plasma Leptin and Insulin in Newborn and Juvenile Rats
Raff, H., Bruder, E. D., & Jankowski, B. M. (1999) · Endocrine · doi:10.1385/endo:11:1:37 · Cited by 55 · see citing works
Avogaro, A., TOFFOLO, G. M., Valerio, A., & Cobelli, C. (1996) · Diabetes · doi:10.2337/diab.45.10.1373 · Cited by 55 · see citing works
Effect of Neonatal Hypoxia on Leptin, Insulin, Growth Hormone and Body Composition in the Rat
Raff, H., Bruder, E. D., Jankowski, B. M., & Colman, R. J. (2001) · Hormone and Metabolic Research · doi:10.1055/s-2001-14929 · Cited by 54 · see citing works
Obstructive sleep apnea increases hemoglobin A1c levels regardless of glucose tolerance status
Tamura, A., Kawano, Y., Watanabe, T., & Kadota, J. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.04.007 · Cited by 51 · see citing works
Liu, R., Zee, P. C., Chervin, R. D., Arguelles, L. M., Birne, J., Zhang, S., Christoffel, K. K., Brickman, W. J., Zimmerman, D., Wang, B., et al. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2011.04.006 · Cited by 48 · see citing works
Nocturnal oxygen desaturation in diabetic patients with severe autonomic neuropathy
Neumann, C. R., Martinez, D., & Schmid, H. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(95)01053-g · Cited by 39 · see citing works
(2000) · CRC Press eBooks · doi:10.1201/b15277 · Cited by 38 · see citing works
Subjective Sleep Complaints Are Associated With Insulin Resistance in Individuals Without Diabetes
Pyykkönen, A.-J., Isomaa, B., Pesonen, A., Eriksson, J. G., Groop, L., Tuomilehto, J., & Räikkönen, K. (2012) · Diabetes Care · doi:10.2337/dc12-0348 · Cited by 37 · see citing works
Lecube, A., Sampol, G., Lloberes, P., Romero, O., Mesa, J., Hernández, C., & Simó, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004692 · Cited by 36 · see citing works
Altered Control of Ventilation in Streptozotocin-Induced Diabetic Rats
Hein, M. S., Schlenker, E. H., & Patel, K. P. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-207-43809 · Cited by 34 · see citing works
Central Nervous System Circuitry Involved in the Hyperinsulinism Syndrome
Lechín, F., & van der Dijs, B. (2006) · Neuroendocrinology · doi:10.1159/000098005 · Cited by 33 · see citing works
Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus
Kashine, S., Kishida, K., Funahashi, T., Nakagawa, Y., Otuki, M., Okita, K., Iwahashi, H., Kihara, S., Nakamura, T., Matsuzawa, Y., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.08.025 · Cited by 32 · see citing works
IFTIKHAR, I. H., & Blankfield, R. P. (2012) · Lung · doi:10.1007/s00408-012-9404-x · Cited by 30 · see citing works
Value of Weight Reduction in Patients with Cardiovascular Disease
Artham, S. M., Lavie, C. J., Milani, R. V., & Ventura, H. O. (2010) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-009-0056-y · Cited by 30 · see citing works
Risk factors for developing sleep-disordered breathing in patients with recent ischaemic stroke.
Noradina, A. T., Hamidon, B. B., Roslan, H., & Raymond, A. A. (2006) · PubMed · Cited by 28 · see citing works
Sleep Apnea and Metabolic Dysfunction: Cause or Co-Relation?
Aurora, R. N., & Punjabi, N. M. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.006 · Cited by 26 · see citing works
Self-citationObstructive sleep apnea syndrome: the effect of diabetes and autonomic neuropathy.
Keller, T., Hader, C., de Zeeuw, J., et al. (2007) · PubMed · Cited by 25 · see citing works
Physical exercise related improvement in obstructive sleep apnea. Look for the rostral fluid shift
Mirrakhimov, A. E. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.11.007 · Cited by 18 · see citing works
Avogaro, A., TOFFOLO, G. M., Valerio, A., et al. (1996) · Padua Research Archive (University of Padova) · Cited by 17 · see citing works
Newman, A. B. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.20.2408 · Cited by 5 · see citing works
Obstructive Sleep Apnea and Metabolic Dysfunction
Polotsky, V. Y., Jun, J. C., & Punjabi, N. M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00114-6 · Cited by 5 · see citing works
Self-citationObstructive sleep apnea and glucose metabolism
Polak, J., Beamer, B. A., & Punjabi, N. M. (2011) · Informa Healthcare eBooks · doi:10.3109/9781420020885.014 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study
Heinzer, R., Vat, S., Marques-Vidal, P., Marti-Soler, H., Andries, D., Tobback, N., Mooser, V, Preisig, M., Malhotra, A., Waeber, G., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00043-0 · Cited by 2,481 · see citing works
Obstructive sleep apnoea syndrome
Lévy, P., Kohler, M., McNicholas, W. T., Barbé, F., McEvoy, R. D., Somers, V. K., Lavie, L., & Pépin, J.-L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.15 · Cited by 1,235 · see citing works
Pamidi, S., Wroblewski, K., Stepien, M., Sharif-Sidi, K., Kilkus, J., Whitmore, H., & Tasali, E. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201408-1564oc · Cited by 185 · see citing works
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173 · see citing works
Self-citationIftikhar, I. H., Hoyos, C. M., Phillips, C. L., & Magalang, U. J. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4610 · Cited by 126 · see citing works
The Interlinked Rising Epidemic of Insufficient Sleep and Diabetes Mellitus
Chattu, V. K., Chattu, S. K., Burman, D., Spence, D. W., & Pandi-Perumal, S. R. (2019) · Healthcare · doi:10.3390/healthcare7010037 · Cited by 87 · see citing works
Cardiometabolic Risk in PCOS: More than a Reproductive Disorder
Torchen, L. C. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0956-2 · Cited by 65 · see citing works
Xia, W., Huang, Y., Peng, B., Zhang, X., Wu, Q., Sang, Y., Luo, Y., Liu, X., Chen, Q., & Tian, K. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.03.016 · Cited by 57 · see citing works
Association between obstructive sleep apnea syndrome and nocturia: a meta-analysis
Zhou, J., Xia, S., Li, T., & Liu, R. (2020) · Sleep and Breathing · doi:10.1007/s11325-019-01981-6 · Cited by 41 · see citing works
Sleep apnoea, insulin resistance and diabetes: the first step is in the fat
Almendros, I., & García-Río, F. (2017) · European Respiratory Journal · doi:10.1183/13993003.00179-2017 · Cited by 34 · see citing works
Bublitz, M. H., Monteiro, J. F., Caraganis, A., Martin, S., Parker, J., Larson, L., Miller, M. A., & Bourjeily, G. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6888 · Cited by 34 · see citing works
Trinh, M. D., Plihalova, A., Gojda, J., Westlake, K., Spicka, J., Lattova, Z., Pretl, M., & Polak, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-83018-1 · Cited by 20 · see citing works
Arosemena, M., Chopra, K., Salguero, M. V., Reyes, D., Naylor, R. N., Wroblewski, K., Tasali, E., & Philipson, L. H. (2026) · Diabetes · doi:10.2337/db24-0787 · Cited by 2 · see citing works
- Authors
- Aurora, R. N., & Punjabi, N. M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Punjabi, Naresh M
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 1
- Issue
- 4
- Pages
- 329-338
- ISSN
- 2213-2600 (ISSN-L)
- OpenAlex
- W2108091559
- Cited by
- 273
- References
- 101
- Citations by year
- 2026: 18 · 2025: 32 · 2024: 16 · 2023: 20 · 2022: 20 · 2021: 21 · 2020: 23 · 2019: 18 · 2018: 26 · 2017: 16 · 2016: 24 · 2015: 25 · 2014: 14
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL075078, HL075078)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- obstructive sleep apnea, type 2 diabetes, bidirectional relationship, sleep fragmentation, insulin resistance, impaired glucose tolerance, central sleep apnea, peripheral neuropathy, ventilation control, screening, cardiovascular risk
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Risk Factors, Global Health, Incidence, Risk Assessment, Disease Management, Sleep Apnea, Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
