Short sleep duration is associated with insulin resistance independent of adiposity in Chinese adult twins
Open accessAbstract
Objective To investigate the association between sleep duration and insulin resistance in rural Chinese adults and examine whether any such associations are independent of adiposity.Methods This is a cross-sectional analysis of 854 men and 640 women aged 20 to 70 years from the Anqing Twin Cohort. The following measures were obtained for each subject: Body mass index (BMI) and percentage of trunk fat (%TF), fasting plasma glucose, homeostatic model assessment of insulin resistance index (HOMA-IR), self-reported sleep duration and measures of snoring and sleep disturbance from the Pittsburgh Sleep Quality Indices (PSQI) questionnaire were modified for a Chinese population. Multivariate linear regressions were applied to examine the association of sleep duration with HOMA-IR, with and without adjustment for adiposity variables, along with other relevant covariates.Results In this sample of relatively lean rural Chinese adults, short sleep duration was associated with HOMA-IR in women but not in men. In women, short (≤ 7 h/night) sleep duration was associated with a higher HOMA-IR (p=0.003) compared with normal sleep duration (>7 to ≤ 8 h/night) after adjustment for all the covariates except adiposity. Further adjustment for BMI or %TF attenuated the sleep-HOMA-IR association, but the association remained significant upon adjustment for BMI (p=0.013); and upon adjustment for %TF (p=0.026). Long sleep duration (> 8 h/night) was not significantly associated with HOMA-IR.Conclusion In this rural Chinese cohort, short sleep duration is independently associated with increased insulin resistance among women only, even after adjusting for adiposity and other potential confounders.
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The effect of short sleep duration on impaired insulin and glucose metabolism may be mediated by increased central adiposity.
“Furthermore, it appears that the effect of short sleep duration on impaired insulin and glucose metabolism may be mediated by increased central adiposity.”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [16]
In a cross-sectional cohort study of Chinese twins, self-reported short sleep duration was associated with greater insulin resistance in women but not in men, an effect partially mediated by visceral adiposity.
“In a crosssectional cohort study of Chinese twins, self-reported short sleep duration was associated with greater insulin resistance in women but not in men, an effect that was partially mediated by visceral adiposity.16”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [16]
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- Authors
- Liu, R., Zee, P. C., Chervin, R. D., Arguelles, L. M., Birne, J., Zhang, S., Christoffel, K. K., Brickman, W. J., Zimmerman, D., Wang, B., Wang, G., Xu, X., & Wang, X.
- Affiliations
- Northwestern University (US)
- University of Michigan (US)
- University of Illinois Chicago (US)
- Corresponding author
- Wang, Xiaobin
- ORCID
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 12
- Issue
- 9
- Pages
- 914-919
- ISSN
- 1389-9457 (ISSN-L)
- PMC
- PMC3210935
- OpenAlex
- W2118030780
- Cited by
- 48
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 2
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG032227)
- National Heart, Lung, and Blood Institute (R01HL086461)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049059)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep duration, insulin resistance, adiposity, sex differences, body mass index, trunk fat, HOMA-IR, rural Chinese adults, snoring, sleep disorders, sleep quality
- MeSH terms
- Adult, Aged, Body Weight, China, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Male, Middle Aged, Risk Factors, Rural Population, Sleep Deprivation, Twins, Prevalence, Asian People, Adiposity, Young Adult
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