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Cited by 454

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Flavanol monomer-induced changes to the human faecal microflora

Open access
Tzounis, Xenofon, Vulevic, Jelena, Kuhnle, Gunter G. C., George, Trevor, Leonczak, Jadwiga, Gibson, Glenn R., Kwik-Uribe, Catherine, Spencer, Jeremy P. E.·2008·British Journal of Nutrition
DOI 10.1017/s0007114507853384
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Abstract

We have investigated the bacterial-dependent metabolism of ( − )-epicatechin and (+)-catechin using a pH-controlled, stirred, batch-culture fermentation system reflective of the distal region of the human large intestine. Incubation of ( − )-epicatechin or (+)-catechin (150 mg/l or 1000 mg/l) with faecal bacteria, led to the generation of 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone, 5-phenyl-γ-valerolactone and phenylpropionic acid. However, the formation of these metabolites from (+)-catechin required its initial conversion to (+)-epicatechin. The metabolism of both flavanols occurred in the presence of favourable carbon sources, notably sucrose and the prebiotic fructo-oligosaccharides, indicating that bacterial utilisation of flavanols also occurs when preferential energy sources are available. (+)-Catechin incubation affected the growth of select microflora, resulting in a statistically significant increase in the growth of the Clostridium coccoides–Eubacterium rectale group,Bifidobacterium spp. and Escherichia coli, as well as a significant inhibitory effect on the growth of the C. histolyticum group. In contrast, the effect of ( − )-epicatechin was less profound, only significantly increasing the growth of the C. coccoides–Eubacterium rectale group. These potential prebiotic effects for both (+)-catechin and ( − )-epicatechin were most notable at the lower concentration of 150 mg/l. As both ( − )-epicatechin and (+)-catechin were converted to the same metabolites, the more dramatic change in the growth of distinct microfloral populations produced by (+)-catechin incubation may be linked to the bacterial conversion of (+)-catechin to (+)-epicatechin. Together these data suggest that the consumption of flavanol-rich foods may support gut health through their ability to exert prebiotic actions.

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Metadata

Authors
Tzounis, X., Vulevic, J., Kuhnle, G. G. C., George, T., Leonczak, J., Gibson, G. R., Kwik-Uribe, C., & Spencer, J. P. E.
Venue
British Journal of Nutrition
Publisher
Cambridge University Press (CUP)
Published
2007-11-01
Volume
99
Issue
4
Pages
782-792
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1017/s0007114507853384
OpenAlex
W2134801225
Cited by
454
References
5
FWCI
3.23
Type
journal article
Language
en
Open access
bronze

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