Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial
Abstract
CONTEXT: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism is the central feature of PCOS. Studies on isolated ovarian theca-interstitial cells suggest that resveratrol, a natural polyphenol, reduces androgen production. OBJECTIVE: This study was designed to evaluate endocrine and metabolic effects of resveratrol on PCOS. DESIGN AND SETTING: This was a randomized (1:1) double-blind, placebo-controlled trial that evaluated the effects of resveratrol over a period of 3 months in an academic hospital. PATIENTS AND OTHER PARTICIPANTS: Subjects with PCOS were identified according to the Rotterdam criteria. Thirty-four subjects were enrolled and 30 subjects completed the trial. Evaluations were performed at baseline and repeated after 3 months of treatment. INTERVENTION: Resveratrol (1,500 mg p.o.) or placebo were administered daily. MAIN OUTCOME MEASURE: Primary outcome was the change in the serum total T. RESULTS: Resveratrol treatment led to a significant decrease of total T by 23.1% (P = .01). In parallel, resveratrol induced a 22.2% decrease of dehydroepiandrosterone sulfate (P = .01), a decrease of fasting insulin level by 31.8% (P = .007) and an increase of the Insulin Sensitivity Index (Matsuda and DeFronzo) by 66.3% (P = .04). Levels of gonadotropins, the lipid profile as well as markers of inflammation and endothelial function were not significantly altered. CONCLUSIONS: Resveratrol significantly reduced ovarian and adrenal androgens. This effect may be, at least in part, related to an improvement of insulin sensitivity and a decline of insulin level.
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In a randomized placebo-controlled trial, treatment with 1500 mg daily of resveratrol significantly decreased testosterone and dehydroepiandrosterone sulfate excess by ~23% in PCOS women over 3 months.
“In a randomized placebo-controlled trial, treatment with 1500 mg daily of resveratrol significantly decreased testosterone and dehydroepiandrosterone sulfate excess by ~23% in PCOS women over a period of 3 months [138].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [138]
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- Authors
- Banaszewska, B., Wrotyńska-Barczyńska, J., Spaczynski, R. Z., Pawelczyk, L., & Duleba, A. J.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2016-11
- Volume
- 101
- Issue
- 11
- Pages
- 4322-4328
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2532986090
- Cited by
- 173
- References
- 35
- Citations by year
- 2026: 21 · 2025: 14 · 2024: 22 · 2023: 23 · 2022: 23 · 2021: 24 · 2020: 16 · 2019: 17 · 2018: 7 · 2017: 6
- FWCI
- 13.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- resveratrol, polycystic ovary syndrome, hyperandrogenism, serum total testosterone, dehydroepiandrosterone sulfate, insulin sensitivity, fasting insulin, insulin resistance, insulin-like growth factor I, ovarian androgen production, adrenal androgens, lipid profile, inflammation, endothelial function
- MeSH terms
- Resveratrol, Adult, Antioxidants, Double-Blind Method, Female, Humans, Insulin, Insulin Resistance, Polycystic Ovary Syndrome, Stilbenes, Testosterone, Outcome Assessment, Health Care, Dehydroepiandrosterone Sulfate
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