Psychological treatment of perinatal depression: a meta-analysis
Open accessAbstract
BACKGROUND: Depression during pregnancy and after the birth of a child is highly prevalent and an important public health problem. Psychological interventions are the first-line treatment and, although a considerable number of randomized trials have been conducted, no recent comprehensive meta-analysis has evaluated treatment effects. METHODS: We used an existing database of randomized controlled trials of psychotherapies for adult depression and included studies aimed at perinatal depression. Random effects models were used in all analyses. We examined the effects of the interventions in the short and long term, and also examined secondary outcomes. RESULTS: = 80%; 95% CI 75~85). This effect size remained largely unchanged and significant in a series of sensitivity analyses, although some publication bias was found. The effects remained significant at 6-12 months follow-up. Significant effects were also found for social support, anxiety, functional limitations, parental stress and marital stress, although the number of studies for each outcome was low. All results should be considered with caution because of the high levels of heterogeneity in most analyses. CONCLUSIONS: Psychological interventions are probably effective in the treatment of perinatal depression, with effects that last at least up to 6-12 months and probably also have effects on social support, anxiety, functional impairment, parental stress, and marital stress.
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A significant portion of women do not respond to treatment for PMADs (~10-40% do not see improvements in depression).
“Second, a significant portion of women do not respond to treatment (~10–40% do not see improvements in depression) [18].”
From Acceptance-based process variables on postpartum well-being and distress: The mediating role of psychological flexibility (2024) · cites this paper as [18]
The Results section, Table 2, reports average treatment effects and numbers needed to treat, not the proportion of women whose depression does not improve. The Methods section uses an assumed control-group response rate to calculate those numbers; it does not establish the claimed 10–40% nonresponse rate. Searches for nonresponse and improvement rates found no passage supporting that figure. (LLM, conf=0.75)
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Self-citationThe neurosteroid paradigm in perinatal depression: From pathophysiology to precision therapeutics
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- Authors
- Cuijpers, P., Franco, P., Ciharova, M., Miguel, C., Segre, L., Quero, S., & Karyotaki, E.
- Affiliations
- Amsterdam Public Health (NL)
- Pontificia Universidad Católica de Chile (CL)
- University of Iowa (US)
- Universitat Jaume I (ES)
- Corresponding author
- Cuijpers, Pim
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2021-11-16
- Volume
- 53
- Issue
- 6
- Pages
- 2596-2608
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC10123831
- OpenAlex
- W3212134895
- Cited by
- 103
- References
- 111
- Citations by year
- 2026: 24 · 2025: 33 · 2024: 22 · 2023: 16 · 2022: 6 · 2021: 2
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Psychological Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Repositori UJI (Universitat Jaume I) (submittedVersion, cc-by)
- OSF Preprints (OSF Preprints) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Chilean National Agency for Research and Development (ANID) / Scholarship Program (DOCTORADO NACIONAL/ 2019 – 21190745)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- perinatal depression, psychological intervention, psychotherapy, treatment effectiveness, postpartum depression, pregnancy, social support, anxiety, functional disability, parental stress, marital stress, long-term outcomes
- MeSH terms
- Adult, Anxiety, Anxiety Disorders, Child, Depression, Depressive Disorder, Female, Humans, Pregnancy, Psychotherapy
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