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Cited by 18Child Abuse and TraumaEpigenetics and DNA MethylationChild and Adolescent Psychosocial and Emotional Development

Childhood adversity predicts black young adults’ DNA methylation-based accelerated aging: A dual pathway model

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Beach, Steven R. H., Gibbons, Frederick X., Carter, Sierra E., Ong, Mei Ling, Lavner, Justin A., Lei, Man-Kit, Simons, Ronald L., Gerrard, Meg +1 more·2022·Development and Psychopathology
DOI 10.1017/s0954579421001541PMC PMC9207155
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Abstract

We expand upon prior work (Gibbons et al., 2012) relating childhood stressor effects, particularly harsh childhood environments, to risky behavior and ultimately physical health by adding longer-term outcomes – deoxyribonucleic acid (DNA) methylation-based measures of accelerated aging (DNA m-aging). Further, following work on the effects of early exposure to danger (McLaughlin et al., 2014), we also identify an additional pathway from harsh childhood environments to DNA m-aging that we label the danger/FKBP5 pathway, which includes early exposure to dangerous community conditions that are thought to impact glucocorticoid regulation and pro-inflammatory mechanisms. Because different DNA m-aging indices provide different windows on accelerated aging, we contrast effects on early indices of DNA m-aging based on chronological age with later indices that focused on predicting biological outcomes. We utilize data from Family and Community Health Study participants (N = 449) from age 10 to 29. We find that harshness influences parenting, which, in turn, influences accelerated DNA m-aging through the risky cognitions and substance use (i.e., behavioral) pathway outlined by Gibbons et al. (2012). Harshness is also associated with increased exposure to threat/danger, which, in turn, leads to accelerated DNA m-aging through effects on FKBP5 activity and enhanced pro-inflammatory tendencies (i.e., the danger/FKBP5 pathway).

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  • Racial trauma has biological impacts (central nervous system, endocrine, metabolic, immune, cardiovascular), interpersonal consequences (conduct problems, adjustment problems, externalizing problems, difficulty in romantic relationships), cognitive effects (internalizing problems, self-esteem), socioeconomic consequences (difficulty maintaining a job, unemployment, poverty), and major long-term健康?

    “There are biological impacts (central nervous system, endocrine, metabolic, immune, cardiovascular), interpersonal consequences (conduct problems, adjustment problems, externalizing problems, difficulty in romantic relationships), cognitive effects (internalizing problems, self-esteem), socioeconomic consequences (difficulty maintaining a job, unemployment, poverty), and major long-term health”

    From Complex Racial Trauma: Evidence, Theory, Assessment, and Treatment (2023) · cites this paper as Beach et al., 2022

    The Environmental Harshness among Black Youth section links racial discrimination to poorer well-being and downstream health and health-behavior consequences; the dual-pathway discussion describes potential nervous-system effects and later health risks. The paper does not support the full list of specific interpersonal, cognitive, and socioeconomic consequences—such as romantic-relationship difficulties, low self-esteem, and unemployment—attributed to it. No page numbers are available in our copy. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Beach, S. R. H., Gibbons, F. X., Carter, S. E., Ong, M. L., Lavner, J. A., Lei, M.-K., Simons, R. L., Gerrard, M., & Philibert, R. A.
Affiliations
  • University of Georgia (US)
  • University of Connecticut (US)
  • Georgia State University (US)
  • University of Iowa (US)
Corresponding author
Beach, Steven R. H.
ORCID
Venue
Development and Psychopathology
Publisher
Cambridge University Press (CUP)
Published
2021-12-20
Volume
34
Issue
2
Pages
689-703
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
DOI
10.1017/s0954579421001541
PMC
PMC9207155
OpenAlex
W4200005256
Cited by
18
References
17
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4
FWCI
2.22
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG055393)
  • National Institute on Drug Abuse (P50DA051361, R01DA021898, R01DA018871)
  • National Cancer Institute (R01CA220254)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD080749)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
childhood adversity, harsh parenting, DNA methylation, accelerated aging, epigenetics, young adults, FKBP5, glucocorticoid regulation, inflammation, risk-taking, substance use, biological aging
MeSH terms
Adverse Childhood Experiences, Adolescent, Adult, Aging, Animals, Child, DNA, Humans, Hylobates, DNA Methylation, Epigenesis, Genetic, Young Adult

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