Effectiveness of Transdiagnostic Cognitive Behaviour Therapy for Anxiety and Depression in Adults: A Systematic Review and Meta-analysis
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Background:Transdiagnostic Cognitive Behaviour Therapy (CBT) seeks to identify core cognitive-behavioural processes hypothesized to be important across a range of disorders and to develop a treatment that targets these. This contrasts with standard CBT approaches that are disorder-specific. Proponents of transdiagnostic CBT suggest that it may offer advantages over disorder-specific CBT, but little is known about the effectiveness of this approach.Aims:The review aimed to summarize trial-based clinical and cost-effectiveness data on transdiagnostic CBT for anxiety and depression.Method:A systematic review of electronic databases, including peer-reviewed and grey literature sources, was conducted (n= 1167 unique citations).Results:Eight trials were eligible for inclusion in the review. There was evidence of an effect for transdiagnostic CBT when compared to a control condition. There were no differences between transdiagnostic CBT and active treatments in two studies. We found no evidence of cost-effectiveness data.Conclusions:Quality assessment of the primary studies indicated a number of methodological concerns that may serve to inflate the observed effects of transdiagnostic approaches. Although there are positive signs of the value of transdiagnostic CBT, there is as yet insufficient evidence to recommend its use in place of disorder-specific CBT.
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Improvements in one dimension of psychological experiences are associated with improvements in further dimensions of psychological experiences.
“the concept of the transdiagnostic approach (97, 100–109) reflects the observation that improvements in one dimension of psychological experiences are associated with improvements in further dimensions of psychological experiences.”
From Sleep disturbances and psychological well-being among military medical doctors of the Swiss Armed Forces: study protocol, rationale and development of a cross-sectional and longitudinal interventional study (2024) · cites this paper as [100]
The Introduction (page unavailable) describes cognitive and behavioural processes common across depressive and anxiety conditions. The Discussion (page unavailable) reports that transdiagnostic CBT improved anxiety, depression and generic mental-health symptoms compared with controls. These findings support improvement across several dimensions, but the review does not establish that improvement in one dimension is associated with improvement in another, or extend that observation to psychological experiences generally. (LLM, conf=0.83)
Experimental — accuracy not yet measuredRecent advances in research on transdiagnostic treatments for anxiety disorders in adults have generally suggested that they are at least as effective as disorder-specific cognitive behavioral therapy approaches.
“Recent advances in research on transdiagnostic treatments for anxiety disorders in adults have generally suggested that they are at least as effective as disorder-specific cognitive behavioral therapy (CBT) approaches”
From Comparison between obsessive compulsive disorder and panic disorder on metacognitive beliefs, emotional schemas, and cognitive flexibility (2019) · cites this paper as Andersen et al. 2016
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TRANSDİYAGNOSTİK BİLİŞSEL DAVRANIŞÇI TERAPİ: BİR ÖRNEK OLARAK BÜTÜNLEŞİK PROTOKOLPreprint
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Self-citation
- Authors
- Andersen, P., Toner, P., Bland, M., & McMillan, D.
- Affiliations
- University of York (GB)
- Corresponding author
- McMillan, Dean
- Venue
- Behavioural and Cognitive Psychotherapy
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-06-15
- Volume
- 44
- Issue
- 6
- Pages
- 673-690
- ISSN
- 1352-4658 (ISSN-L)
- 1469-1833
- OpenAlex
- W2434828969
- Cited by
- 128
- References
- 56
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 13 · 2023: 18 · 2022: 9 · 2021: 38 · 2020: 10 · 2019: 14 · 2018: 5 · 2017: 6
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Behavioural and Cognitive Psychotherapy (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- anxiety disorders, depression, transdiagnostic mechanisms, treatment effectiveness, cost-effectiveness, adults
- MeSH terms
- Adult, Anxiety, Anxiety Disorders, Depression, Depressive Disorder, Female, Humans, Male, Middle Aged, Cognitive Behavioral Therapy, Treatment Outcome, Evidence-Based Practice
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