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Cited by 580

The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.

Polymeric Conjugates for Drug Delivery

Open access
Larson, Nate, Ghandehari, Hamidreza·2012·Chemistry of Materials
DOI 10.1021/cm2031569
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Abstract

The field of polymer therapeutics has evolved over the past decade and has resulted in the development of polymer-drug conjugates with a wide variety of architectures and chemical properties. Whereas traditional non-degradable polymeric carriers such as poly(ethylene glycol) (PEG) and N-(2-hydroxypropyl methacrylamide) (HPMA) copolymers have been translated to use in the clinic, functionalized polymer-drug conjugates are increasingly being utilized to obtain biodegradable, stimuli-sensitive, and targeted systems in an attempt to further enhance localized drug delivery and ease of elimination. In addition, the study of conjugates bearing both therapeutic and diagnostic agents has resulted in multifunctional carriers with the potential to both "see and treat" patients. In this paper, the rational design of polymer-drug conjugates will be discussed followed by a review of different classes of conjugates currently under investigation. The design and chemistry used for the synthesis of various conjugates will be presented with additional comments on their potential applications and current developmental status.

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Metadata

Authors
Larson, N., & Ghandehari, H.
Venue
Chemistry of Materials
Publisher
American Chemical Society (ACS)
Published
2012-01-04
Volume
24
Issue
5
Pages
840-853
ISSN
  • 0897-4756 (ISSN-L)
  • 1520-5002
DOI
10.1021/cm2031569
OpenAlex
W2072198924
Cited by
580
References
187
FWCI
15.99
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.