Modulators of Protein–Protein Interactions

Cites (624)

Items 201–400 of 624

1. Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction
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2. Structures and stereochemistry of new labdane diterpiniods from coleus forskohlii briq.
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3. Phosphorylation of Thr-948 at the C Terminus of the Plasma Membrane H+-ATPase Creates a Binding Site for the Regulatory 14-3-3 Protein
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4. Design and Structure of Stapled Peptides Binding to Estrogen Receptors
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5. Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling
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6. Bioactivity-Guided Navigation of Chemical Space
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7. Genomics-inspired discovery of natural products
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8. Crystal Structure of ARF1•Sec7 Complexed with Brefeldin A and Its Implications for the Guanine Nucleotide Exchange Mechanism
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9. Structure, Mechanism, and Regulation of Mammalian Adenylyl Cyclase
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10. Structures of peptides from α‐amino acids methylated at the α‐carbon,
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11. Synthetic non-peptide mimetics of α-helices
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12. Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex
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13. Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action
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14. Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions
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15. In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide
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16. Interactome under construction
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17. Protein Dimerization Induced by Supramolecular Interactions with Cucurbit[8]uril
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18. Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis
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19. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
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20. A Highly Stable Short α-Helix Constrained by a Main-Chain Hydrogen-Bond Surrogate
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21. Interactive exploration of chemical space with Scaffold Hunter
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22. K+Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases
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23. A Molecular Tweezer for Lysine and Arginine
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24. Synthesis of Natural‐Product‐Like Molecules with Over Eighty Distinct Scaffolds
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25. Expanding the Genetic Code for Biological Studies
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26. A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity
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27. Crystal Structure of a β-Catenin/BCL9/Tcf4 Complex
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28. Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions
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29. Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis
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30. Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure
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31. Beta-Strand Mimetics
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32. X-ray structure of a decameric cyclophilin-cyclosporin crystal complex
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33. Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries
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34. A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor
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35. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure
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36. Protein camouflage in cytochrome c–calixarene complexes
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37. Small‐Molecule Stabilization of Protein–Protein Interactions: An Underestimated Concept in Drug Discovery?
    Philipp Thiel, Markus Kaiser, Christian Ottmann · 2012 · Angewandte Chemie International Edition
38. Stapled Peptides with Improved Potency and Specificity That Activate p53
    Christopher John Brown, Soo Tng Quah, Janice Jong, Amanda M. Goh, Poh Cheang Chiam, Kian Hoe Khoo, Meng Ling Choong, May A. Lee, Larisa Yurlova, Kourosh Zolghadr et al. · 2012 · ACS Chemical Biology
39. High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction
    Hacer Karataş, Elizabeth C. Townsend, Fang Cao, Yong Chen, Denzil Bernard, Liu Liu, Ming Lei, Yali Dou, Shaomeng Wang · 2012 · Journal of the American Chemical Society
40. Diversity in GeneticIn VivoMethods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System
    Bram Stynen, Hélène Tournu, Jan H. Tavernier, Patrick Van Dijck · 2012 · Microbiology and Molecular Biology Reviews
41. Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants
    Sean R. Miller, Yoshiki Sekijima, Jeffery W. Kelly · 2004 · Laboratory Investigation
42. Expanding the genetic code of Drosophila melanogaster
    Ambra Bianco, Fiona M. Townsley, Sebastian Greiss, Kathrin Lang, Jason W. Chin · 2012 · Nature Chemical Biology
43. Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
    Inge Van Molle, Andreas Thomann, Dennis L. Buckley, Ernest C. So, Steffen Lang, Craig M. Crews, Alessio Ciulli · 2012 · Chemistry & Biology
44. Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry
    Venugopal T. Bhat, Anne M. Caniard, Torsten Luksch, Ruth Brenk, Dominic J. Campopiano, Michael F. Greaney · 2010 · Nature Chemistry
45. The use of phosphate bioisosteres in medicinal chemistry and chemical biology
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46. Molecular tweezers modulate 14-3-3 protein–protein interactions
    David Bier, Rolf Rose, Kenny Bravo‐Rodriguez, Maria Bartel, Juan Manuel Ramírez‐Anguita, Som Dutt, Constanze Wilch, Frank‐Gerrit Klärner, Elsa Sánchez‐García, Thomas H. Schrader et al. · 2013 · Nature Chemistry
47. The Pathway by Which the Tetrameric Protein Transthyretin Dissociates
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48. Supramolecular chemistry: from molecular information towards self-organization and complex matter
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49. Structures of Human Transthyretin Complexed with Thyroxine at 2.0 Å Resolution and 3',5'-Dinitro-N-acetyl- L -thyronine at 2.2 Å Resolution
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50. Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors
    Jochim, Andrea L., Arora, Paramjit S. · 2010 · ACS Chemical Biology
51. Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery
    Chun‐wa Chung, Anthony W. Dean, James M. Woolven, Paul Bamborough · 2011 · Journal of Medicinal Chemistry
52. Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes
    Loı̈c Martin, François Stricher, Dorothée Missé, Francesca M. Sironi, Martine Pugnière, Philippe Barthe, Rafael Prado‐Gotor, Isabelle Freulon, Xavier Magne, Christian Roumestand et al. · 2002 · Nature Biotechnology
53. Studying protein–protein interactions using peptide arrays
    Chen Katz, Liron Levy‐Beladev, Shahar Rotem‐Bamberger, Tiago Rito, Stefan Rüdiger, Assaf Friedler · 2011 · Chemical Society Reviews
54. Bioluminescence resonance energy transfer (BRET) imaging of protein–protein interactions within deep tissues of living subjects
    Dragulescu-Andrasi, Anca, Chan, Carmel T., De, Abhijit, Massoud, Tarik F., Gambhir, Sanjiv S. · 2011 · Proceedings of the National Academy of Sciences
55. Molecular Recognition of Amino Acids, Peptides, and Proteins by Cucurbit[n]uril Receptors
    Adam R. Urbach, Vijayakumar Ramalingam · 2011 · Israel Journal of Chemistry
56. A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells
    Miranda, Elena, Nordgren, Ida K., Male, Abigail L., Lawrence, Charlotte E., Hoakwie, Franciane, Cuda, Francesco, Court, William, Fox, Keith R., Townsend, Paul A., Packham, Graham K. et al. · 2013 · Journal of the American Chemical Society
57. High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment Assay
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58. Identification of novel mdm2 binding peptides by phage display.
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59. Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays
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60. β-Peptides as inhibitors of protein–protein interactions
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61. Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency
    Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Gómez, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni, Fairlie, David P. · 2010 · Proceedings of the National Academy of Sciences
62. Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance
    Anna Bergamaschi, Benita S. Katzenellenbogen · 2011 · Oncogene
63. Interaction of Gsα with the Cytosolic Domains of Mammalian Adenylyl Cyclase
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64. The BRET technology and its application to screening assays
    Johan Bacart, Caroline Corbel, Ralf Jockers, Stéphane Bach, Cyril Couturier · 2008 · Biotechnology Journal
65. Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses
    Stephen Connelly, Sungwook Choi, Steven M. Johnson, Jeffery W. Kelly, Ian A. Wilson · 2010 · Current Opinion in Structural Biology
66. Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides
    Paul Bamborough, Hawa Diallo, Jonathan D. Goodacre, Laurie J. Gordon, Antonia J. Lewis, Jonathan T. Seal, David M. Wilson, Michael D. Woodrow, Chun‐wa Chung · 2011 · Journal of Medicinal Chemistry
67. Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
    Phan, Jason, Li, Zhenyu, Kasprzak, Agnieszka, Li, Baozong, Sebti, Said, Guida, Wayne, Schönbrunn, Ernst, Chen, Jiandong · 2010 · Journal of Biological Chemistry
68. S100A4: a common mediator of epithelial–mesenchymal transition, fibrosis and regeneration in diseases?
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69. Technological advances in high-throughput screening
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70. Fragment Based Drug Design: From Experimental to Computational Approaches
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71. The Hydrogen Bond Mimic Approach: Solid-Phase Synthesis of a Peptide Stabilized as an α-Helix with a Hydrazone Link
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72. Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms
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73. The fusicoccin receptor of plants is a member of the 14‐3‐3 superfamily of eukaryotic regulatory proteins
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74. Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure−Activity Studies of (+)-Migrastatin
    Jón T. Njardarson, Christoph Gaul, Dandan Shan, Xin-Yun Huang, Samuel J. Danishefsky · 2004 · Journal of the American Chemical Society
75. Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
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76. Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites
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77. An Unconventional NLS is Critical for the Nuclear Import of the Influenza A Virus Nucleoprotein and Ribonucleoprotein
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78. Can self‐inhibitory peptides be derived from the interfaces of globular protein–protein interactions?
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79. The 14-3-3 proteins: cellular regulators of plant metabolism
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80. A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
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81. High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐x L
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82. Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation
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83. α/β-Peptide foldamers: state of the art
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84. Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors
    Muppidi, Avinash, Doi, Kenichiro, Edwardraja, Selvakumar, Drake, Eric J., Gulick, Andrew M., Wang, Hong-Gang, Lin, Qing · 2012 · Journal of the American Chemical Society
85. Probing the Structural Requirements of Peptoids That Inhibit HDM2−p53 Interactions
    Toshiaki J. Hara, Stewart R. Durell, Michael C. Myers, Daniel H. Appella · 2006 · Journal of the American Chemical Society
86. Construction of Protein Nanowires through Cucurbit[8]uril‐based Highly Specific Host–Guest Interactions: An Approach to the Assembly of Functional Proteins
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87. Interaction with 14‐3‐3 proteins promotes functional expression of the potassium channels TASK‐1 and TASK‐3
    Sindhu Rajan, Regina Preisig‐Müller, Erhard Wischmeyer, Ralf Bernd Nehring, Peter J. Hanley, Vijay Renigunta, Boris Musset, Günter Schlichthörl, Christian Derst, Andreas Karschin et al. · 2002 · The Journal of Physiology
88. Inhibition of HIV Budding by a Genetically Selected Cyclic Peptide Targeting the Gag−TSG101 Interaction
    Tavassoli, Ali, Lu, Quan, Gam, Jongsik, Pan, Hui, Benkovic, Stephen J., Cohen, Stanley N. · 2008 · ACS Chemical Biology
89. Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain
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90. A Structural and in Vitro Characterization of Asoprisnil: A Selective Progesterone Receptor Modulator
    Kevin P. Madauss, Eugene T. Grygielko, Su-Jun Deng, Anthony C. Sulpizio, Thomas B. Stanley, Charlene W. Wu, Steven A. Short, Scott K. Thompson, Eugene L. Stewart, Nicholas J. Laping et al. · 2007 · Molecular Endocrinology
91. New assay technologies for high-throughput screening
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92. Sequence‐Based Design of α/β‐Peptide Foldamers That Mimic BH3 Domains
    W. Seth Horne, Melissa Boersma, Matthew A. Windsor, Samuel H. Gellman · 2008 · Angewandte Chemie International Edition
93. Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold
    Ian Robert Hardcastle, Shafiq Uddin Ahmed, Helen Atkins, Gillian Farnie, Bernard T. Golding, Roger J. Griffin, Sabrina Guyenne, Claire Hutton, Per Källblad, Stuart J. Kemp et al. · 2006 · Journal of Medicinal Chemistry
94. Interaction of 14-3-3 proteins with the Estrogen Receptor Alpha F domain provides a drug target interface
    Ingrid J. de Vries-van Leeuwen, Daniel Da Costa Pereira, Koen D. Flach, Sander R. Piersma, Christian Haase, David Bier, Zeliha Yalçin, Rob J. A. M. Michalides, K. Anton Feenstra, Connie R. Jiménez et al. · 2013 · Proceedings of the National Academy of Sciences
95. Ribosomal production and in vitro selection of natural product-like peptidomimetics: The FIT and RaPID systems
    Christopher J. Hipolito, Hiroaki Suga · 2012 · Current Opinion in Chemical Biology
96. Methods and options for the heterologous production of complex natural products
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97. Constrained Peptides with Target‐Adapted Cross‐Links as Inhibitors of a Pathogenic Protein–Protein Interaction
    Glas, Adrian, Bier, David, Hahne, Gernot, Rademacher, Christoph, Ottmann, Christian, Grossmann, Tom N. · 2014 · Angewandte Chemie International Edition
98. Exploring New Chemical Space by Stereocontrolled Diversity-Oriented Synthesis
    P. Arya, Reni Joseph, Zhonghong Gan, Bojana Rakić · 2005 · Chemistry & Biology
99. Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction
    Jeffrey P. Plante, Thomas Burnley, Barbora Malkova, Michael E. Webb, Stuart L. Warriner, Thomas A. Edwards, Andrew John Wilson · 2009 · Chemical Communications
100. Discovering transthyretin amyloid fibril inhibitors by limited screening
     Paul W. Baures, Scott Peterson, Jeffery W. Kelly · 1998 · Bioorganic & Medicinal Chemistry
101. Bioactivity-guided mapping and navigation of chemical space
     Steffen Renner, Willem A. L. van Otterlo, Marta Domínguez, Sabine Möcklinghoff, Bettina Hofmann, Stefan Wetzel, Ansgar Schuffenhauer, Peter Ertl, Tudor Ionel Oprea, Dieter Steinhilber et al. · 2009 · Nature Chemical Biology
102. Chemical, Biological and Clinical Aspects of Dexrazoxane and Other Bisdioxopiperazines
     Brian B. Hasinoff, K. Hellmann, Erik Herman, Victor J. Ferrans · 1998 · Current Medicinal Chemistry
103. Ribosome Display: A Perspective
     Andreas Plückthun · 2011 · Methods in molecular biology
104. Organic synthesis toward small-molecule probes and drugs
     Stuart L. Schreiber · 2011 · Proceedings of the National Academy of Sciences
105. X-ray Crystal Structures of the Estrogen-related Receptor-γ Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation
     Liping Wang, William J. Zuercher, Thomas G. Consler, Millard H. Lambert, Aaron B. Miller, Lisa A. Orband‐Miller, David D. McKee, Timothy Mark Willson, Robert T. Nolte · 2006 · Journal of Biological Chemistry
106. Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors
     Steven M. Johnson, Stephen Connelly, Ian A. Wilson, Jeffery W. Kelly · 2007 · Journal of Medicinal Chemistry
107. Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity
     Okamoto, Toru, Zobel, Kerry, Fedorova, Anna, Quan, Clifford, Yang, Hong, Fairbrother, Wayne J., Huang, David C. S., Smith, Brian J., Deshayes, Kurt, Czabotar, Peter E. · 2013 · ACS Chemical Biology
108. Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix
     Laura K. Henchey, Swati Kushal, Ramin Dubey, Ross N. Chapman, Bogdan Z. Olenyuk, Paramjit S. Arora · 2009 · Journal of the American Chemical Society
109. Quantification of the Thermodynamically Linked Quaternary and Tertiary Structural Stabilities of Transthyretin and Its Disease-Associated Variants: The Relationship between Stability and Amyloidosis
     Amy R. Hurshman Babbes, Evan T. Powers, Jeffery W. Kelly · 2008 · Biochemistry
110. Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid
     Paul W. Baures, Vibha B. Oza, Scott Peterson, Jeffery W. Kelly · 1999 · Bioorganic & Medicinal Chemistry
111. Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists
     Anna Czarna, Barbara Beck, Stuti Srivastava, Grzegorz M. Popowicz, Siglinde Wolf, Yijun Huang, Michał Biśta, Tad A. Holak, Alexander S. S. Dömling · 2010 · Angewandte Chemie International Edition
112. Synthesis, Structure, and Activity of Diclofenac Analogues as Transthyretin Amyloid Fibril Formation Inhibitors
     Vibha B. Oza, Craig Smith, Prakash Raman, Edward K. Koepf, Hilal Ahmed Lashuel, H. Mike Petrassi, Kyle P. Chiang, Evan T. Powers, James Sachettinni, Jeffery W. Kelly · 2001 · Journal of Medicinal Chemistry
113. In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors
     Yuuki Hayashi, Jumpei Morimoto, Hiroaki Suga · 2012 · ACS Chemical Biology
114. Gambogic Acid, a Natural Product Inhibitor of Hsp90
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115. Structure–Activity Studies in a Family of β‐Hairpin Protein Epitope Mimetic Inhibitors of the p53–HDM2 Protein–Protein Interaction
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116. Screening Bicyclic Peptide Libraries for Protein–Protein Interaction Inhibitors: Discovery of a Tumor Necrosis Factor-α Antagonist
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