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Boronate-Based Fluorescent Probes for Imaging Cellular Hydrogen Peroxide
Open accessAbstract
The syntheses, properties, and biological applications of the Peroxysensor family, a new class of fluorescent probes for hydrogen peroxide, are presented. These reagents utilize a boronate deprotection mechanism to provide high selectivity and optical dynamic range for detecting H2O2 in aqueous solution over similar reactive oxygen species (ROS) including superoxide, nitric oxide, tert-butyl hydroperoxide, hypochlorite, singlet oxygen, ozone, and hydroxyl radical. Peroxyresorufin-1 (PR1), Peroxyfluor-1 (PF1), and Peroxyxanthone-1 (PX1) are first-generation probes that respond to H2O2 by an increase in red, green, and blue fluorescence, respectively. The boronate dyes are cell-permeable and can detect micromolar changes in H2O2 concentrations in living cells, including hippocampal neurons, using confocal microscopy and two-photon microscopy. The unique combination of ROS selectivity, membrane permeability, and a range of available excitation/emission colors establishes the potential value of PR1, PF1, PX1, and related probes for interrogating the physiology and pathology of cellular H2O2.
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Metadata
- Authors
- Miller, E. W., Albers, A. E., Pralle, A., Isacoff, E. Y., & Chang, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-11-05
- Volume
- 127
- Issue
- 47
- Pages
- 16652-16659
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2064203348
- Cited by
- 591
- References
- 3
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- green
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