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Cited by 368

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Direct Intestinal Absorption of Red Fruit Anthocyanins, Cyanidin-3-glucoside and Cyanidin-3,5-diglucoside, into Rats and Humans

Miyazawa, Teruo, Nakagawa, Kiyotaka, Kudo, Miyuki, Muraishi, Kayo, Someya, Keita·1999·Journal of Agricultural and Food Chemistry
DOI 10.1021/jf9809582
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Abstract

We determined red fruit anthocyanins, cyanidin-3-glucoside (Cy-g) and cyanidin-3,5-diglucoside (Cy-dg), incorporated into plasma and liver of rats and human plasma by UV-HPLC. Fifteen minutes after an oral supplementation of a mixture of 320 mg of Cy-g and 40 mg of Cy-dg/kg of body weight, rats showed an increase to a maximum of 1563 microg (3490 nmol) of Cy-g/L and 195 microg (320 nmol) of Cy-dg/L in plasma and 0.067 microg (0.15 nmol) of Cy-g/g and a trace of Cy-dg together with methylated metabolites such as peonidin-3-glucoside in liver. In human plasma, 30 min after intake (2.7 mg of Cy-g and 0.25 mg of Cy-dg/kg of body weight), an average of 11 microg (24 nmol) of Cy-g/L and a trace of Cy-dg were found. Cyanidin as aglycone of Cy-g and Cy-dg was not found in such plasma samples, neither were conjugated and methylated anthocyanins. The results indicated that anthocyanins are incorporated keeping structurally intact glycoside forms, from the digestive tract into the blood circulation system in mammals.

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Metadata

Authors
Miyazawa, T., Nakagawa, K., Kudo, M., Muraishi, K., & Someya, K.
Venue
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Published
1999-02-09
Volume
47
Issue
3
Pages
1083-1091
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
DOI
10.1021/jf9809582
OpenAlex
W1981145469
Cited by
368
References
19
FWCI
7.59
Type
journal article
Language
en
Open access
closed

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