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Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats
Abstract
It is essential to determine the biodistribution, clearance, and biocompatibility of magnetic nanoparticles (MNPs) for in vivo biomedical applications to ensure their safe clinical use. We have studied these aspects with our novel iron oxide MNP formulation, which can be used as a magnetic resonance imaging (MRI) agent and a drug carrier system. Changes in serum and tissue iron levels were analyzed over 3 weeks after intravenous administration of MNPs to rats. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP) levels, and total iron-binding capacity (TIBC) were also measured with time to assess the effect of MNPs on liver function. Selected tissues were also analyzed for oxidative stress and studied histologically to determine biocompatibility of MNPs. Serum iron levels gradually increased for up to 1 week but levels slowly declined thereafter. Biodistribution of iron in various body tissues changed with time but greater fraction of the injected iron localized in the liver and spleen than in the brain, heart, kidney, and lung. Magnetization measurements of the liver and spleen samples showed a steady decrease over 3 weeks, suggesting particle degradation. Serum showed a transient increase in ALT, AST, AKP levels, and TIBC over a period of 6-24 h following MNP injection. The increase in oxidative stress was tissue dependent, reaching a peak at approximately 3 days and then slowly declining thereafter. Histological analyses of liver, spleen, and kidney samples collected at 1 and 7 days showed no apparent abnormal changes. In conclusion, our MNPs did not cause long-term changes in the liver enzyme levels or induce oxidative stress and thus can be safely used for drug delivery and imaging applications.
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Cites
Sources and role of iron in lipid peroxidation
Minotti, G. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00032a001 · Cited by 154
Cited by
Longmire, M., Choyke, P. L., & Kobayashi, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.703 · Cited by 2,149
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,010
Synthesis, characterization, applications, and challenges of iron oxide nanoparticles
Ali, A., Zafar, H., Zia, M., ul Haq, I., Phull, A. R., Ali, J. S., & Hussain, A. (2016) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s99986 · Cited by 1,591
Nanoparticles as drug delivery systems
Wilczewska, A. Z., Niemirowicz, K., Markiewicz, K. H., & Car, H. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70901-5 · Cited by 1,445
Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
Wahajuddin, & Arora (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30320 · Cited by 1,117
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Singh, N., Jenkins, G. J. S., Asadi, R., & Doak, S. H. (2010) · Nano Reviews · doi:10.3402/nano.v1i0.5358 · Cited by 1,112
Alternative Antimicrobial Approach: Nano-Antimicrobial Materials
Beyth, N., Houri-Haddad, Y., Domb, A., Khan, W., & Hazan, R. (2015) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2015/246012 · Cited by 837
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830
Soenen, S. J., Rivera-Gil, P., Montenegro, J.-M., Parak, W. J., De Smedt, S. C., & Braeckmans, K. (2011) · Nano Today · doi:10.1016/j.nantod.2011.08.001 · Cited by 699
In vitro assessments of nanomaterial toxicity
Jones, C. F., & Grainger, D. W. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.005 · Cited by 554
Kunzmann, A., Andersson, B., Thurnherr, T., Krug, H., Scheynius, A., & Fadeel, B. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.04.007 · Cited by 527
Nanotheranostics for personalized medicine
Mura, S., & Couvreur, P. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.06.006 · Cited by 527
Balasubramanian, S. K., Jittiwat, J., Manikandan, J., Ong, C.-N., Yu, L. E., & Ong, W.-Y. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.079 · Cited by 522
Nanomaterials for Neural Interfaces
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504
Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
Malhotra, N., Lee, J.-S., Liman, R. A. D., Ruallo, J. M. S., Villaflores, O. B., Ger, T.-R., & Hsiao, C.-D. (2020) · Molecules · doi:10.3390/molecules25143159 · Cited by 470
Cancer theranostics: the rise of targeted magnetic nanoparticles
Cole, A. J., Yang, V. C., & David, A. E. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2011.03.001 · Cited by 425
Analytical methods to assess nanoparticle toxicity
Marquis, B. J., Love, S. A., Braun, K. L., & Haynes, C. L. (2009) · The Analyst · doi:10.1039/b818082b · Cited by 406
Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells
Pujalté, I., Passagne, I., Brouillaud, B., Tréguer, M., Durand, E., Ohayon-Courtès, C., & L'Azou, B. (2011) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-8-10 · Cited by 398
In vitro Toxicity Testing of Nanoparticles in 3D Cell Culture
Lee, J., Lilly, G. D., Doty, R. C., Podsiadlo, P., & Kotov, N. A. (2009) · Small · doi:10.1002/smll.200801788 · Cited by 373
Multifunctional nanoparticles for brain tumor imaging and therapy
Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., & Lesniak, M. S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.006 · Cited by 349
Lee, N., Choi, Y., Lee, Y., Park, M., Moon, W. K., Choi, S. H., & Hyeon, T. (2012) · Nano Letters · doi:10.1021/nl3010308 · Cited by 293
Application of Iron Magnetic Nanoparticles in Protein Immobilization
Xu, J., Sun, J., Wang, Y., Sheng, J., Wang, F., & Sun, M. (2014) · Molecules · doi:10.3390/molecules190811465 · Cited by 290
Biodegradable and Renal Clearable Inorganic Nanoparticles
Ehlerding, E. B., Chen, F., & Cai, W. (2016) · Advanced Science · doi:10.1002/advs.201500223 · Cited by 277
Schleich, N., Po, C., Jacobs, D., Ucakar, B., Gallez, B., Danhier, F., & Préat, V. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.059 · Cited by 238
Talelli, M., Rijcken, C. J. F., Lammers, T., Seevinck, P. R., Storm, G., van Nostrum, C. F., & Hennink, W. E. (2009) · Langmuir · doi:10.1021/la8036499 · Cited by 210
Alizadeh, S., Seyedalipour, B., Shafieyan, S., Kheime, A., Mohammadi, P., & Aghdami, N. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.110 · Cited by 162
Magnetic Nanoparticle Targeted Hyperthermia of Cutaneous Staphylococcus aureus Infection
Kim, M.-H., Yamayoshi, I., Mathew, S., Lin, H., Nayfach, J., & Simon, S. I. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-012-0698-x · Cited by 135
Magnetic Nanostructures: Rational Design and Fabrication Strategies toward Diverse Applications
Wang, S., Xu, J., Li, W., Sun, S., Gao, S., & Hou, Y. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00370 · Cited by 129
Iron oxide-loaded nanotheranostics: major obstacles to in vivo studies and clinical translation
Schleich, N., Danhier, F., & Préat, V. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.024 · Cited by 124
Gaharwar, U. S., Meena, R., & Rajamani, P. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s223142 · Cited by 75
NDong, C., Tate, J. A., Kett, W. C., Batra, J., Demidenko, E., Lewis, L. D., Hoopes, P. J., Gerngross, T. U., & Griswold, K. E. (2015) · PLOS ONE · doi:10.1371/journal.pone.0115636 · Cited by 50
Metadata
- Authors
- Jain, T. K., Reddy, M. K., Morales, M. A., Leslie-Pelecky, D. L., & Labhasetwar, V.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-01-25
- Volume
- 5
- Issue
- 2
- Pages
- 316-327
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2047855476
- Cited by
- 705
- References
- 1
- FWCI
- 26.86
- Type
- journal article
- Language
- en
- Open access
- closed
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