The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors
Open accessAbstract
Second near-infrared (NIR) window light (950-1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas.
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Second window for in vivo imaging
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Next-generation in vivo optical imaging with short-wave infrared quantum dots
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A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities
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Biosensing with Fluorescent Carbon Nanotubes
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New role of bacteriophages in medical oncology
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Metadata
- Authors
- Yi, H., Ghosh, D., Ham, M.-H., Qi, J., Barone, P. W., Strano, M. S., & Belcher, A. M.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-02-06
- Volume
- 12
- Issue
- 3
- Pages
- 1176-1183
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2334075244
- Cited by
- 278
- References
- 4
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- green
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