Cell-Penetrating Peptides: Design, Synthesis, and Applications

Antimicrobial peptides of multicellular organisms

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Regulated portals of entry into the cell

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Mechanisms of phagocytosis in macrophages

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Cellular uptake of the tat protein from human immunodeficiency virus

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Functions of Cell Surface Heparan Sulfate Proteoglycans

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Design and development of polymers for gene delivery

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A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

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The third helix of the Antennapedia homeodomain translocates through biological membranes.

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Arginine-rich Peptides

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Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis

Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647

Pathways of clathrin-independent endocytosis

Mayor, S., & Pagano, R. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2216 · Cited by 1,556

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

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Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

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Polyarginine enters cells more efficiently than other polycationic homopolymers

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Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent

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Mechanisms of Cellular Uptake of Cell-Penetrating Peptides

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Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural Protein

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Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics

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Tumor imaging by means of proteolytic activation of cell-penetrating peptides

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Local Dystrophin Restoration with Antisense Oligonucleotide PRO051

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A Comprehensive Model for the Cellular Uptake of Cationic Cell‐penetrating Peptides

Duchardt, F., Fotin‐Mleczek, M., Schwarz, H., Fischer, R., & Brock, R. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00572.x · Cited by 771

Trojan peptides: the penetratin system for intracellular delivery

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Internalization of HIV-1 Tat Requires Cell Surface Heparan Sulfate Proteoglycans

Tyagi, M., Rusnati, M., Presta, M., & Giacca, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006701200 · Cited by 719

Interaction of antimicrobial dermaseptin and its fluorescently labeled analogs with phospholipid membranes

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Cell penetration by transportan

Pooga, M., Hällbrink, M., Zorko, M., & Langel, U. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.67 · Cited by 679

New Chemical Descriptors Relevant for the Design of Biologically Active Peptides. A Multivariate Characterization of 87 Amino Acids

Sandberg, M., Eriksson, L., Jonsson, J., Sjöström, M., & Wold, S. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm9700575 · Cited by 678

Cellular Uptake of Unconjugated TAT Peptide Involves Clathrin-dependent Endocytosis and Heparan Sulfate Receptors

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Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

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Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

Fonseca, S. B., Pereira, M. P., & Kelley, S. O. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.001 · Cited by 553

A new peptide vector for efficient delivery of oligonucleotides into mammalian cells

Morris, M. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.14.2730 · Cited by 535

Studies on the Internalization Mechanism of Cationic Cell-penetrating Peptides

Drin, G., Cottin, S., Blanc, E., Rees, A. R., & Temsamani, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303938200 · Cited by 530

Arginine‐rich cell‐penetrating peptides

Schmidt, N., Mishra, A., Lai, G. H., & Wong, G. C. L. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.11.046 · Cited by 521

Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

Simeoni, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg385 · Cited by 480

Stearylated Arginine-Rich Peptides: A New Class of Transfection Systems

Futaki, S., Ohashi, W., Suzuki, T., Niwa, M., Tanaka, S., Ueda, K., Harashima, H., & Sugiura, Y. (2001) · Bioconjugate Chemistry · doi:10.1021/bc015508l · Cited by 464

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

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Cellular uptake of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

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Cell-penetrating and cell-targeting peptides in drug delivery

Vivès, E., Schmidt, J., & Pèlegrin, A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.03.001 · Cited by 441

Possible Existence of Common Internalization Mechanisms among Arginine-rich Peptides

Suzuki, T., Futaki, S., Niwa, M., Tanaka, S., Ueda, K., & Sugiura, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110017200 · Cited by 430

Interaction of Arginine-Rich Peptides with Membrane-Associated Proteoglycans Is Crucial for Induction of Actin Organization and Macropinocytosis

Nakase, I., Tadokoro, A., Kawabata, N., Takeuchi, T., Katoh, H., Hiramoto, K., Negishi, M., Nomizu, M., Sugiura, Y., & Futaki, S. (2007) · Biochemistry · doi:10.1021/bi0612824 · Cited by 429

The design of guanidinium-rich transporters and their internalization mechanisms

Wender, P. A., Galliher, W. C., Goun, E. A., Jones, L. R., & Pillow, T. H. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.016 · Cited by 425

Cell Penetrating Peptides: Intracellular Pathways and Pharmaceutical Perspectives

Patel, L. N., Zaro, J. L., & Shen, W.-C. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9303-7 · Cited by 425

Antennapedia and HIV Transactivator of Transcription (TAT) “Protein Transduction Domains” Promote Endocytosis of High Molecular Weight Cargo upon Binding to Cell Surface Glycosaminoglycans

Console, S., Marty, C., García-Echeverría, C., Schwendener, R., & Ballmer-Hofer, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301726200 · Cited by 421

In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis

Cao, G., Pei, W., Ge, H., Liang, Q., Luo, Y., Sharp, F. R., Lu, A., Ran, R., Graham, S. H., & Chen, J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05423.2002 · Cited by 419

Bactericidal antisense effects of peptide–PNA conjugates

Good, L., Awasthi, S. K., Dryselius, R., Larsson, O., & Nielsen, P. E. (2001) · Nature Biotechnology · doi:10.1038/86753 · Cited by 391

?-Poly-l-lysine: microbial production, biodegradation and application potential

Yoshida, T., & Nagasawa, T. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1312-9 · Cited by 387

Cell-penetrating peptides as delivery vehicles for biology and medicine

Stewart, K. M., Horton, K. L., & Kelley, S. O. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b719950c · Cited by 381

Pathway for Polyarginine Entry into Mammalian Cells

Fuchs, S. M., & Raines, R. T. (2004) · Biochemistry · doi:10.1021/bi035933x · Cited by 374

Multifunctional host defense peptides: intracellular‐targeting antimicrobial peptides

Nicolas, P. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07359.x · Cited by 361

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

Crombez, L., Aldrian-Herrada, G., Konate, K., Nguyen, Q. N., McMaster, G. K., Brasseur, R., Heitz, F., & Divita, G. (2009) · Molecular Therapy · doi:10.1038/mt.2008.215 · Cited by 346

Translocation and Endocytosis for Cell-penetrating Peptide Internalization

Jiao, C.-Y., Delaroche, D., Burlina, F., Alves, I. D., Chassaing, G., & Sagan, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056309 · Cited by 345

Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides

Nakase, I., Takeuchi, T., Tanaka, G., & Futaki, S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.10.006 · Cited by 342

Caveolae-Mediated internalization of extracellular HIV-1 tat fusion proteins visualized in real time

Ferrari, A., Pellegrini, V., Arcangeli, C., Fittipaldi, A., Giacca, M., & Beltram, F. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00122-9 · Cited by 335

Secondary structure of cell-penetrating peptides controls membrane interaction and insertion

Eiríksdóttir, E., Konate, K., Langel, Ü., Divita, G., & Deshayes, S. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.03.005 · Cited by 323

Delivery of short interfering RNA using endosomolytic cell‐penetrating peptides

Lundberg, P., El‐Andaloussi, S., Sütlü, T., Johansson, H., & Langel, Ü. (2007) · The FASEB Journal · doi:10.1096/fj.06-6502com · Cited by 322

Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery

MAE, M., & LANGEL, U. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.04.004 · Cited by 317

Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides

Lättig-Tünnemann, G., Prinz, M., Hoffmann, D., Behlke, J., Palm-Apergi, C., Morano, I., Herce, H. D., & Cardoso, M. C. (2011) · Nature Communications · doi:10.1038/ncomms1459 · Cited by 308

Arginine-Rich Peptides Destabilize the Plasma Membrane, Consistent with a Pore Formation Translocation Mechanism of Cell-Penetrating Peptides

Herce, H. D., Garcia, A. E., Litt, J., Kane, R. S., Martin, P., Enrique, N., Rebolledo, A., & Milesi, V. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.05.066 · Cited by 305

Uptake of analogs of penetratin, Tat(48–60) and oligoarginine in live cells

Thorén, P. E. G., Persson, D., Isakson, P., Goksör, M., Önfelt, A., & Nordén, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01135-5 · Cited by 303

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

EL Andaloussi, S., Lehto, T., Mäger, I., Rosenthal-Aizman, K., Oprea, I. I., Simonson, O. E., Sork, H., Ezzat, K., Copolovici, D. M., Kurrikoff, K., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1299 · Cited by 301

Deletion analogues of transportan

Soomets, U., Lindgren, M., Gallet, X., Hällbrink, M., Elmquist, A., Balaspiri, L., Zorko, M., Pooga, M., Brasseur, R., & Langel, Ü. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00216-9 · Cited by 283

The Cationic Cell-Penetrating Peptide CPPTAT Derived from the HIV-1 Protein TAT Is Rapidly Transported into Living Fibroblasts: Optical, Biophysical, and Metabolic Evidence

Ziegler, A., Nervi, P., Dürrenberger, M., & Seelig, J. (2005) · Biochemistry · doi:10.1021/bi0491604 · Cited by 266

Mechanisms of Antimicrobial, Cytolytic, and Cell-Penetrating Peptides: From Kinetics to Thermodynamics

Almeida, P. F., & Pokorny, A. (2009) · Biochemistry · doi:10.1021/bi900914g · Cited by 265

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

Olson, E. S., Aguilera, T. A., Jiang, T., Ellies, L. G., Nguyen, Q. T., Wong, E. H., Gross, L. A., & Tsien, R. Y. (2009) · Integrative Biology · doi:10.1039/b904890a · Cited by 263

‘Detergent-like’ permeabilization of anionic lipid vesicles by melittin

Ladokhin, A. S., & White, S. H. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00382-0 · Cited by 257

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

Dubikovskaya, E. A., Thorne, S. H., Pillow, T. H., Contag, C. H., & Wender, P. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805374105 · Cited by 249

Arginine-rich peptides and their internalization mechanisms

Futaki, S., Nakase, I., Tadokoro, A., Takeuchi, T., & Jones, A. T. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350784 · Cited by 246

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

Ezzat, K., EL Andaloussi, S., Zaghloul, E. M., Lehto, T., Lindberg, S., Moreno, P. M. D., Viola, J. R., Magdy, T., Abdo, R., Guterstam, P., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr072 · Cited by 236

Cell entry of cell penetrating peptides: tales of tails wagging dogs

Jones, A. T., & Sayers, E. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.003 · Cited by 234

Morpholinos and their peptide conjugates: Therapeutic promise and challenge for Duchenne muscular dystrophy

Moulton, H. M., & Moulton, J. D. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.02.012 · Cited by 229

Comparison of Cellular Uptake Using 22 CPPs in 4 Different Cell Lines

Mueller, J., Kretzschmar, I., Volkmer, R., & Boisguerin, P. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800194e · Cited by 208

Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide

Lindgren, M., Rosenthal-Aizman, K., Saar, K., Eiríksdóttir, E., Jiang, Y., Sassian, M., Östlund, P., Hällbrink, M., & Langel, Ü. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.048 · Cited by 207

Binding of Oligoarginine to Membrane Lipids and Heparan Sulfate: Structural and Thermodynamic Characterization of a Cell-Penetrating Peptide

Gonçalves, E., Kitas, E., & Seelig, J. (2005) · Biochemistry · doi:10.1021/bi048046i · Cited by 201

Treatment of Terminal Peritoneal Carcinomatosis by a Transducible p53-Activating Peptide

Snyder, E. L., Meade, B. R., Saenz, C. C., & Dowdy, S. F. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020036 · Cited by 199

Insight into the Mechanism of Internalization of the Cell-Penetrating Carrier Peptide Pep-1 through Conformational Analysis

Deshayes, S., Heitz, A., Morris, M. C., Charnet, P., Divita, G., & Heitz, F. (2004) · Biochemistry · doi:10.1021/bi035682s · Cited by 198

Protein Kinase C δ Mediates Cerebral Reperfusion Injury In Vivo

Bright, R., Raval, A. P., Dembner, J. M., Pérez-Pinzón, M. A., Steinberg, G. K., Yenari, M. A., & Mochly-Rosen, D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4474-03.2004 · Cited by 198

Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides

Aguilera, T. A., Olson, E. S., Timmers, M. M., Jiang, T., & Tsien, R. Y. (2009) · Integrative Biology · doi:10.1039/b904878b · Cited by 198

Peptides for cell-selective drug delivery

Svensen, N., Walton, J. G. A., & Bradley, M. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.02.002 · Cited by 195

Protein Cargo Delivery Properties of Cell-Penetrating Peptides. A Comparative Study

Säälik, P., Elmquist, A., Hansen, M., Padari, K., Saar, K., Viht, K., Langel, Ü., & Pooga, M. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049938y · Cited by 195

Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth

Crombez, L., Morris, M. C., Dufort, S., Aldrian-Herrada, G., Nguyen, Q., Mc Master, G., Coll, J.-L., Heitz, F., & Divita, G. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp451 · Cited by 193

Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice

Tezel, G., Yang, X., Yang, J., & Wax, M. B. (2004) · Brain Research · doi:10.1016/j.brainres.2003.10.029 · Cited by 192

Tryptophan fluorescence study of the interaction of penetratin peptides with model membranes

Christiaens, B., Symoens, S., Vanderheyden, S., Engelborghs, Y., Joliot, A., Prochiantz, A., Vandekerckhove, J., Rosseneu, M., & Vanloo, B. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02963.x · Cited by 191

Cell‐Penetrating Homochiral Cyclic Peptides as Nuclear‐Targeting Molecular Transporters

Mandal, D., Nasrolahi Shirazi, A., & Parang, K. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201102572 · Cited by 191

Mechanism of the Cell-Penetrating Peptide Transportan 10 Permeation of Lipid Bilayers

Yandek, L. E., Pokorny, A., Florén, A., Knoelke, K., Langel, Ü., & Almeida, P. F. F. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.100198 · Cited by 190

A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy

Mäe, M., EL Andaloussi, S., Lundin, P., Oskolkov, N., Johansson, H. J., Guterstam, P., & Langel, Ü. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.11.025 · Cited by 187

Handbook of Cell-Penetrating Peptides

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Distinct Uptake Routes of Cell-Penetrating Peptide Conjugates

Lundin, P., Johansson, H., Guterstam, P., Holm, T., Hansen, M., Langel, Ü., & EL Andaloussi, S. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800212j · Cited by 183

Usefulness of cell-penetrating peptides to improve intestinal insulin absorption

Kamei, N., Morishita, M., Eda, Y., Ida, N., Nishio, R., & Takayama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.08.001 · Cited by 177

Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.

Kokenyesi, R., & Bernfield, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32716-3 · Cited by 173

Oral biodrug delivery using cell-penetrating peptide

Khafagy, E.-S., & Morishita, M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.014 · Cited by 173

A Novel Cell-penetrating Peptide, M918, for Efficient Delivery of Proteins and Peptide Nucleic Acids

El-Andaloussi, S., Johansson, H. J., Holm, T., & Langel, Ü. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300255 · Cited by 170

Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation

Khalil, I., Futaki, S., Niwa, M., Baba, Y., Kaji, N., Kamiya, H., & Harashima, H. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302128 · Cited by 166

Transbilayer Transport of Ions and Lipids Coupled with Mastoparan X Translocation

Matsuzaki, K., Yoneyama, S., Murase, O., & Miyajima, K. (1996) · Biochemistry · doi:10.1021/bi960342a · Cited by 166

Beyond the walls of the nucleus: the role of histones in cellular signaling and innate immunityThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

Parseghian, M. H., & Luhrs, K. A. (2006) · Biochemistry and Cell Biology · doi:10.1139/o06-082 · Cited by 163

Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery

Melikov, K., & Chernomordik, L. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5293-y · Cited by 159

Predicting cell-penetrating peptides

Hansen, M., Kilk, K., & Langel, Ü. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.003 · Cited by 157

Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo

Nakase, I., Konishi, Y., Ueda, M., Saji, H., & Futaki, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.016 · Cited by 157

Scavenger receptor‐mediated uptake of cell‐penetrating peptide nanocomplexes with oligonucleotides

Ezzat, K., Helmfors, H., Tudoran, O. M., Juks, C., Lindberg, S., Padari, K., Andaloussi, S. E., Pooga, M., & Langel, Ü. (2011) · The FASEB Journal · doi:10.1096/fj.11-191536 · Cited by 156

Prediction of Cell Penetrating Peptides by Support Vector Machines

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Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate

Guterstam, P., Madani, F., Hirose, H., Takeuchi, T., Futaki, S., Andaloussi, S. E., Gräslund, A., & Langel, Ü. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.09.014 · Cited by 153

A novel chimeric cell-penetrating peptide with membrane-disruptive properties for efficient endosomal escape

Salomone, F., Cardarelli, F., Luca, M. D., Boccardi, C., Nifosì, R., Bardi, G., Bari, L. D., Serresi, M., & Beltram, F. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.019 · Cited by 147

Cell-penetrating peptides for the delivery of nucleic acids

Lehto, T., Kurrikoff, K., & Langel, Ü. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.689285 · Cited by 143

Binding and Clustering of Glycosaminoglycans: A Common Property of Mono- and Multivalent Cell-Penetrating Compounds

Ziegler, A., & Seelig, J. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.113472 · Cited by 142

Revised Role of Glycosaminoglycans in TAT Protein Transduction Domain-mediated Cellular Transduction

Gump, J. M., June, R. K., & Dowdy, S. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021964 · Cited by 139

Design of a Tumor-Homing Cell-Penetrating Peptide

Myrberg, H., Zhang, L., Mäe, M. A., & Langel, Ü. (2007) · Bioconjugate Chemistry · doi:10.1021/bc0701139 · Cited by 137

Construction of cell penetrating peptide vectors with N-terminal stearylated nuclear localization signal for targeted delivery of DNA into the cell nuclei

Wang, H.-Y., Chen, J., Sun, Y., Deng, J., Li, C., Zhang, X., & Zhuo, R. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.009 · Cited by 136

D-JNKI1, a Cell-Penetrating c-Jun-N-Terminal Kinase Inhibitor, Protects Against Cell Death in Severe Cerebral Ischemia

Hirt, L., Badaut, J., Thévenet, J., Granziera, C., Regli, L., Maurer, F., Bonny, C., & Bogousslavsky, J. (2004) · Stroke · doi:10.1161/01.str.0000131480.03994.b1 · Cited by 133

Effect of cell-penetrating peptides on the nasal absorption of insulin

Khafagy, E., Morishita, M., Isowa, K., Imai, J., & Takayama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.09.076 · Cited by 130

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy

Lehto, T., Abes, R., Oskolkov, N., Suhorutšenko, J., Copolovici, D. M., Mäger, I., Viola, J. R., Simonson, O. E., Ezzat, K., & Guterstam, P. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.08.028 · Cited by 127

Quantitatively determined uptake of cell-penetrating peptides in non-mammalian cells with an evaluation of degradation and antimicrobial effects

Palm‐Apergi, C., Netzereab, S., & Hällbrink, M. (2006) · Peptides · doi:10.1016/j.peptides.2006.01.006 · Cited by 122

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

Iversen, P. L., Warren, T. K., Wells, J., Garza, N. L., Mourich, D. V., Welch, L. S., Panchal, R. G., & Bavari, S. (2012) · Viruses · doi:10.3390/v4112806 · Cited by 121

On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids

Deshayes, S., Gerbal‐Chaloin, S., Morris, M. C., Aldrian, G., Charnet, P., Divita, G., & Heitz, F. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.09.010 · Cited by 120

Cytotoxicity, intracellular distribution and uptake of doxorubicin and doxorubicin coupled to cell-penetrating peptides in different cell lines: A comparative study

Aroui, S., Brahim, S., WAARD, M. M. D., & Kénani, A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.073 · Cited by 119

Characterization of a Novel Cytotoxic Cell‐penetrating Peptide Derived From p14ARF Protein

Johansson, H. J., Andaloussi, S. E., Holm, T., Mäe, M. A., Jänes, J., Maimets, T., & Langel, Ü. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300346 · Cited by 119

Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis

Nakase, I., Hirose, H., Tanaka, G., Tadokoro, A., Kobayashi, S., Takeuchi, T., & Futaki, S. (2009) · Molecular Therapy · doi:10.1038/mt.2009.192 · Cited by 118

Direct Translocation as Major Cellular Uptake for CADY Self-Assembling Peptide-Based Nanoparticles

Rydström, A., Deshayes, S., Konate, K., Crombez, L., Padari, K., Boukhaddaoui, H., Aldrian, G., Pooga, M., & Divita, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025924 · Cited by 118

Cell-penetrating peptide exploited syndecans

Letoha, T., Keller-Pintér, A., Kúsz, E., Kolozsi, C., Bozsó, Z., Tóth, G. K., Vízler, C., Oláh, Z., & Szilák, L. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.01.022 · Cited by 116

Cell-Penetrating cis-γ-Amino- l -Proline-Derived Peptides

Farrera‐Sinfreu, J., Giralt, E., Castel, S., et al. (2005) · Journal of the American Chemical Society · doi:10.1021/ja051648k · Cited by 114

Structure–activity relationship study of the cell-penetrating peptide pVEC

Elmquist, A., Hansen, M., & Langel, Ü. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.05.013 · Cited by 114

Translocation of the pAntp Peptide and Its Amphipathic Analogue AP-2AL

Drin, G., Déméné, H., Temsamani, J., & Brasseur, R. (2001) · Biochemistry · doi:10.1021/bi002019k · Cited by 112

Intracellular Traffic and Fate of Protein Transduction Domains HIV-1 TAT Peptide and Octaarginine. Implications for Their Utilization as Drug Delivery Vectors

Al‐Taei, S., Penning, N. A., Simpson, J. C., Futaki, S., Takeuchi, T., Nakase, I., & Jones, A. T. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050274h · Cited by 106

N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis

Magzoub, M. M., Sandgren, S., Lundberg, P., Oglęcka, K., Lilja, J., Wittrup, A., Eriksson, L. E. G., Langel, Ü., Belting, M., & Gräslund, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.065 · Cited by 105

Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication

Ahn, D., Lee, W., Choi, J.-K., Kim, S.-J., Plant, E. P., Almazán, F., Taylor, D. R., Enjuanes, L., & Oh, J. (2011) · Antiviral Research · doi:10.1016/j.antiviral.2011.04.009 · Cited by 104

Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and Efficacy

Mo, R. H., Zaro, J. L., & Shen, W. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200481g · Cited by 103

PrPSc-like prion protein peptide inhibits the function of cellular prion protein

Brown, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3520511 · Cited by 101

Cell biology meets biophysics to unveil the different mechanisms of penetratin internalization in cells

Alves, I. D., Jiao, C.-Y., Aubry, S., Aussedat, B., Burlina, F., Chassaing, G., & Sagan, S. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.02.009 · Cited by 99

Design of Carrier Peptide-Oligonucleotide Conjugates with Rapid Membrane Translocation and Nuclear Localization Properties

Chaloin, L., Vidal, P., Lory, P., Méry, J., Lautrédou-Audouy, N., Divita, G., & Heitz, F. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.8050 · Cited by 99

Myristoyl-Based Transport of Peptides into Living Cells

Nelson, A. R., Borland, L. M., Allbritton, N. L., & Sims, C. E. (2007) · Biochemistry · doi:10.1021/bi701295k · Cited by 97

Application of a Novel Analysis To Measure the Binding of the Membrane-Translocating Peptide Penetratin to Negatively Charged Liposomes

Persson, D., Thorén, P. E. G., Herner, M., Lincoln, P., & Nordén, B. (2002) · Biochemistry · doi:10.1021/bi026453t · Cited by 95

Consequences of Nonlytic Membrane Perturbation to the Translocation of the Cell Penetrating Peptide Pep-1 in Lipidic Vesicles

Henriques, S. T., & Castanho, M. A. R. B. (2004) · Biochemistry · doi:10.1021/bi036325k · Cited by 90

Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231

Aroui, S., Brahim, S., WAARD, M. M. D., Bréard, J., & Kénani, A. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.044 · Cited by 89

Differential membrane perturbation caused by the cell penetrating peptide Tp10 depending on attached cargo

Bárány-Wallje, E., Gaur, J., Lundberg, P., Langel, Ü., & Gräslund, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.046 · Cited by 86

Cell Transduction Pathways of Transportans

Padari, K., Säälik, P., Hansen, M., Koppel, K., Raid, R., Langel, Ü., & Pooga, M. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050125z · Cited by 86

The effect of pH on PAMAM dendrimer–siRNA complexation — Endosomal considerations as determined by molecular dynamics simulation

Ouyang, D., Zhang, H., Parekh, H. S., & Smith, S. C. (2011) · Biophysical Chemistry · doi:10.1016/j.bpc.2011.06.003 · Cited by 85

Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers†

Jearawiriyapaisarn, N., Moulton, H. M., Sazani, P., et al. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp335 · Cited by 85

Membrane destabilizing properties of cell-penetrating peptides

Thorén, P. E. G., Persson, D., Lincoln, P., & Nordén, B. (2004) · Biophysical Chemistry · doi:10.1016/j.bpc.2004.11.016 · Cited by 83

Cell-Penetrating Peptides: Methods and Protocols

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Functional Rescue of Dystrophin-deficient mdx Mice by a Chimeric Peptide-PMO

Yin, H., Moulton, H. M., Betts, C., Merritt, T. M., Seow, Y., Ashraf, S., Wang, Q., Boutilier, J. K., & Wood, M. J. A. (2010) · Molecular Therapy · doi:10.1038/mt.2010.151 · Cited by 81

Structural polymorphism of non-covalent peptide-based delivery systems: Highway to cellular uptake

Deshayes, S., Konate, K., Aldrian, G., Crombez, L., Heitz, F., & Divita, G. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.06.005 · Cited by 79

Crossing the blood–brain barrier: A potential application of myristoylated polyarginine for in vivo neuroimaging

Pham, W. N., Zhao, B., Lo, E. H., Medarova, Z. O., Rosen, B. R., & Moore, A. V. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.007 · Cited by 79

p28, A first in class peptide inhibitor of cop1 binding to p53

Yamada, T., Christov, K., Shilkaitis, A., Bratescu, L., Green, A., Santini, S., Bizzarri, A. R., Cannistraro, S., Gupta, T. K. D., & Beattie, C. W. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.266 · Cited by 78

Pathologic Prion Protein Infects Cells by Lipid-Raft Dependent Macropinocytosis

Wadia, J. S., Schaller, M. M., Williamson, R. A., & Dowdy, S. F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003314 · Cited by 74

Assessing the uptake kinetics and internalization mechanisms of cell-penetrating peptides using a quenched fluorescence assay

Mäger, I., Eiríksdóttir, E., Langel, K., Andaloussi, S. E., & Langel, Ü. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.11.001 · Cited by 73

Gene therapy progress and prospects: Duchenne muscular dystrophy

Foster, K., Foster, H., & Dickson, J. G. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302877 · Cited by 72

Intracellular Toxicity of Proline-Rich Antimicrobial Peptides Shuttled into Mammalian Cells by the Cell-Penetrating Peptide Penetratin

Hansen, A., Schäfer, I., Knappe, D., Seibel, P., & Hoffmann, R. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00585-12 · Cited by 72

Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes

Vandenbroucke, R. E., Smedt, S. C. D., Demeester, J., & Sanders, N. N. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.11.006 · Cited by 69

Protein Delivery with Transportans Is Mediated by Caveolae Rather Than Flotillin-Dependent Pathways

Säälik, P., Padari, K., Niinep, A., Lorents, A., Hansen, M., Jokitalo, E., Langel, Ü., & Pooga, M. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800416f · Cited by 68

Physicochemical Mechanism for the Enhanced Ability of Lipid Membrane Penetration of Polyarginine

Takechi, Y., Yoshii, H., Tanaka, M., Kawakami, T., Aimoto, S., & Saito, H. (2011) · Langmuir · doi:10.1021/la200917y · Cited by 67

Interaction of Poly(l-arginine) with Negatively Charged DPPG Membranes: Calorimetric and Monolayer Studies

Schwieger, C., & Blume, A. (2009) · Biomacromolecules · doi:10.1021/bm9003207 · Cited by 64

Cell-penetrating peptides in drug development: enabling intracellular targets

Chen, L., & Harrison, S. D. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350821 · Cited by 63

Biological activity of Tat (47–58) peptide on human pathogenic fungi

Jung, H. J., Park, Y., Hahm, K., & Lee, D. G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.059 · Cited by 63

Generation of Endosomolytic Reagents by Branching of Cell-Penetrating Peptides: Tools for the Delivery of Bioactive Compounds to Live Cells in Cis or Trans

Angeles-Boza, A. M., Erazo‐Oliveras, A., Lee, Y., & Pellois, J. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100130r · Cited by 60

Differential Endosomal Pathways for Radically Modified Peptide Vectors

Arukuusk, P., Pärnaste, L., Margus, H., Eriksson, J., Vasconcelos, D., Padari, K., Pooga, M., & Langel, Ü. (2013) · Bioconjugate Chemistry · doi:10.1021/bc4002757 · Cited by 60

Molecular Partners for Interaction and Cell Internalization of Cell-Penetrating Peptides: How Identical Are They?

Walrant, A., Bechara, C., Alves, I. D., et al. (2011) · Nanomedicine · doi:10.2217/nnm.11.165 · Cited by 60

NickFects, Phosphorylated Derivatives of Transportan 10 for Cellular Delivery of Oligonucleotides

Oskolkov, N., Arukuusk, P., Copolovici, D. M., Lindberg, S., Margus, H., Padari, K., Pooga, M., & Langel, Ü. (2011) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-011-9252-1 · Cited by 59

Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

Hoyer, J., Schatzschneider, U., Schulz‐Siegmund, M., et al. (2012) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.8.204 · Cited by 58

Characterization of prion protein (PrP)-derived peptides that discriminate full-length PrP Sc from PrP C

Lau, A. L., Yam, A. Y.-W., Michelitsch, M. D., Wang, X., Gao, C. M., Goodson, R. J., Shimizu, R. W., Timoteo, G., Hall, J., Medina-Selby, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704260104 · Cited by 56

Characterization of Bioactive Cell Penetrating Peptides from Human Cytochrome c: Protein Mimicry and the Development of a Novel Apoptogenic Agent

Jones, S., Holm, T., Mäger, I., Langel, Ü., & Howl, J. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.05.018 · Cited by 56

Detection of Peptide-Lipid Interactions in Mixed Monolayers, Using Isotherms, Atomic Force Microscopy, and Fourier Transform Infrared Analyses

Vié, V., Mau, N. D. V., Chaloin, L., Lesniewska, É., Grimellec, C. L., & Heitz, F. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76642-2 · Cited by 55

Intracellular delivery : fundamentals and applications

Prokop, A. (2011) · DIAL (Catholic University of Leuven) · doi:10.1007/978-94-007-1248-5 · Cited by 52

Improved Tat-mediated plasmid DNA transfer by fusion to LK15 peptide

Saleh, A. F. A., Aojula, H. S., Arthanari, Y., Offerman, S. C., Alkotaji, M. M., & Pluen, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.12.025 · Cited by 51

Uptake of cell‐penetrating peptides in yeasts

Holm, T., Netzereab, S., Hansen, M., Langel, Ü., & Hällbrink, M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.099 · Cited by 51

Graphical Analysis of Mass and Anisotropy Changes Observed by Plasmon-Waveguide Resonance Spectroscopy Can Provide Useful Insights into Membrane Protein Function

Salamon, Z., & Tollin, G. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74306-4 · Cited by 50

Exogenous and Cell Surface Glycosaminoglycans Alter DNA Delivery Efficiency of Arginine and Lysine Homopeptides in Distinctly Different Ways

Naik, R. J., Chandra, P., Mann, A., & Ganguli, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.227793 · Cited by 50

Cellular Internalization Kinetics of (Luciferin-)Cell-Penetrating Peptide Conjugates

Eiríksdóttir, E., Mäger, I., Lehto, T., Andaloussi, S. E., & Langel, Ü. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100174y · Cited by 50

Cell-Penetrating Peptides for Antiviral Drug Development

Delcroix, M., & Riley, L. W. (2010) · Pharmaceuticals · doi:10.3390/ph3030448 · Cited by 50

Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

Rangel, R., Guzman‐Rojas, L., Roux, L. L., Staquicini, F. I., Hosoya, H., Barbu, E. M., Ozawa, M. G., Nie, J., Dunner, K., Langley, R. R., et al. (2012) · Nature Communications · doi:10.1038/ncomms1773 · Cited by 50

Antimicrobial activity, bactericidal mechanism and LPS‐neutralizing activity of the cell‐penetrating peptide pVEC and its analogs

Nan, Y. H., Park, I., Hahm, K., & Shin, S. Y. (2011) · Journal of Peptide Science · doi:10.1002/psc.1408 · Cited by 49

Cell-penetrating peptides can confer biological function: Regulation of inflammatory cytokines in human monocytes by MK2 inhibitor peptides

Brugnano, J. L., Chan, B. K., Seal, B. L., & Panitch, A. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.05.007 · Cited by 49

Translocation or membrane disintegration? Implication of peptide–membrane interactions in pep‐1 activity

Henriques, S. T., & Castanho, M. A. R. B. (2008) · Journal of Peptide Science · doi:10.1002/psc.1003 · Cited by 48

Inhibition of RNA Virus Infections with Peptide-Conjugated Morpholino Oligomers

Stein, D. A. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786071290 · Cited by 48

The Cell Penetrating Peptides pVEC and W2-pVEC Induce Transformation of Gel Phase Domains in Phospholipid Bilayers without Affecting Their Integrity

Herbig, M. E., Assi, F., Textor, M., & Merkle, H. P. (2006) · Biochemistry · doi:10.1021/bi050923c · Cited by 45

Design of a bioactive cell‐penetrating peptide: when a transduction domain does more than transduce

Ward, B. C., Seal, B. L., Brophy, C. M., & Panitch, A. (2009) · Journal of Peptide Science · doi:10.1002/psc.1168 · Cited by 44

Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins

Yang, B. S., Liu, D., & Huang, Z. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.09.101 · Cited by 43

Chondroitin Sulfate as a Molecular Portal That Preferentially Mediates the Apoptotic Killing of Tumor Cells by Penetratin-directed Mitochondria-disrupting Peptides

Yang, H., Liu, S., Cai, H., Wan, L., Li, S., Li, Y., Cheng, J., & Lu, X. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.089417 · Cited by 43

Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor

Baumgärtner, P., Geiger, M., Zieseniss, S., Malleier, J. M., Huntington, J. A., Hochrainer, K., Bielek, E., Stoeckelhuber, M., Lauber, K., Scherfeld, D., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200707165 · Cited by 40

Bioportide: an emergent concept of bioactive cell-penetrating peptides

Howl, J., Matou‐Nasri, S., West, D. C., Farquhar, M. J., Slaninová, J., Östenson, C., Zorko, M., Östlund, P., Kumar, S., Langel, Ü., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0979-4 · Cited by 40

Membrane aggregation and perturbation induced by antimicrobial peptide of S-thanatin

Wu, G., Wu, H., Li, L. X., Fan, X., Ding, J., Li, X., Xi, T., & Shen, Z. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.107 · Cited by 39

A Thermodynamic Approach to the Mechanism of Cell-Penetrating Peptides in Model Membranes

McKeown, A. N., Naro, J. L., Huskins, L., & Almeida, P. (2011) · Biochemistry · doi:10.1021/bi1013358 · Cited by 38

siRNA Delivery to CNS Cells using a Membrane Translocation Peptide

Ifediba, M. A., Medarova, Z. O., Ng, S., Yang, J., & Moore, A. V. (2010) · Bioconjugate Chemistry · doi:10.1021/bc900488e · Cited by 37

JNK Pathway as Therapeutic Target to Prevent Degeneration in the Central Nervous System

Repici, M., & Borsello, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-34817-9_13 · Cited by 37

Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma

Wender, P. A., Galliher, W. C., Bhat, N. M., Pillow, T. H., Bieber, M. M., & Teng, N. N. H. (2012) · Gynecologic Oncology · doi:10.1016/j.ygyno.2012.03.049 · Cited by 35

Dendrimer Display of Tumor-Homing Peptides

Lempens, E. H. M., Merkx, M., Tirrell, M., & Meijer, E. W. (2011) · Bioconjugate Chemistry · doi:10.1021/bc100403e · Cited by 34

Peptide–glycosaminoglycan cluster formation involving cell penetrating peptides

Rullo, A. F., Qian, J., & Nitz, M. (2011) · Biopolymers · doi:10.1002/bip.21641 · Cited by 34

Cell-penetrating d-Isomer Peptides of p53 C-terminus: Long-term Inhibitory Effect on the Growth of Bladder Cancer

Araki, D., Takayama, K., Inoue, M., Watanabe, T., Kumon, H., Futaki, S., Matsui, H., & Tomizawa, K. (2009) · Urology · doi:10.1016/j.urology.2009.10.002 · Cited by 30

Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus

Ueda, Y., Wei, F., Hide, T.-I., Michiue, H., Takayama, K., Kaitsuka, T., Nakamura, H., Makino, K., Kuratsu, J., Futaki, S., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.003 · Cited by 28

Blockade of viral interleukin-6 expression of Kaposi's sarcoma–associated herpesvirus

Zhang, Y.-J., Bonaparte, R. S., Patel, D., Stein, D. A., & Iversen, P. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2036 · Cited by 27

Cell-penetrating peptides as antifungals towards Malassezia sympodialis

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