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UV-Emitting Upconversion-Based TiO2 Photosensitizing Nanoplatform: Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway
Abstract
Photodynamic therapy (PDT) is a promising antitumor treatment that is based on the photosensitizers that inhibit cancer cells by yielding reactive oxygen species (ROS) after irradiation of light with specific wavelengths. As a potential photosensitizer, titanium dioxide (TiO2) exhibits minimal dark cytotoxicity and excellent ultraviolet (UV) light triggered cytotoxicity, but is challenged by the limited tissue penetration of UV light. Herein, a novel near-infrared (NIR) light activated photosensitizer for PDT based on TiO2-coated upconversion nanoparticle (UCNP) core/shell nanocomposites (UCNPs@TiO2 NCs) is designed. NaYF4:Yb(3+),Tm(3+)@NaGdF4:Yb(3+) core/shell UCNPs can efficiently convert NIR light to UV emission that matches well with the absorption of TiO2 shells. The UCNPs@TiO2 NCs endocytosed by cancer cells are able to generate intracellular ROS under NIR irradiation, decreasing the mitochondrial membrane potential to release cytochrome c into the cytosol and then activating caspase 3 to induce cancer cell apoptosis. NIR light triggered PDT of tumor-bearing mice with UCNPs@TiO2 as photosensitizers can suppress tumor growth efficiently due to the better tissue penetration than UV irradiation. On the basis of the evidence of in vitro and in vivo results, UCNPs@TiO2 NCs could serve as an effective photosensitizer for NIR light mediated PDT in antitumor therapy.
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Cites
Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo
Xue, M., Ge, Y., Zhang, J., Wang, Q., Hou, L., Liu, Y., Sun, L., & Li, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043483 · Cited by 192
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Rare-Earth Doping in Nanostructured Inorganic Materials
Zheng, B., Fan, J., Chen, B., Qin, X., Wang, J., Wang, F., Deng, R., & Liu, X. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00644 · Cited by 1,204
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
Schirinzi, G. F., Pérez-Pomeda, I., Sanchís, J., Rossini, C., Farré, M., & Barceló, D. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.043 · Cited by 902
Conquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Self-citationYang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Self-citationOvercoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
Type I Photosensitizers Revitalizing Photodynamic Oncotherapy
Chen, D., Xu, Q., Wang, W., Shao, J., Huang, W., & Dong, X. (2021) · Small · doi:10.1002/smll.202006742 · Cited by 482
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
X-ray-activated nanosystems for theranostic applications
Chen, X., Song, J., Chen, X., & Yang, H. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00921j · Cited by 401
Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment
Zhang, C., Wang, X., Du, J., Gu, Z., & Zhao, Y. (2021) · Advanced Science · doi:10.1002/advs.202002797 · Cited by 401
Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy
Kamkaew, A., Chen, F., Zhan, Y., Majewski, R. L., & Cai, W. (2016) · ACS Nano · doi:10.1021/acsnano.6b01401 · Cited by 355
Type I photodynamic therapy by organic–inorganic hybrid materials: From strategies to applications
Wang, Y.-Y., Liu, Y.-C., Sun, H., & Guo, D.-S. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2019.05.016 · Cited by 344
Recent advances in metal nanoparticles in cancer therapy
Sharma, A., Goyal, A. K., & Rath, G. (2018) · Journal of Drug Targeting · doi:10.1080/1061186x.2017.1400553 · Cited by 341
Zhang, W., Lu, J., Gao, X., Li, P., Zhang, W., Ma, Y., Wang, H., & Tang, B. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201710800 · Cited by 328
Wang, M., Chang, M., Chen, Q., Wang, D., Li, C., Hou, Z., Lin, J., Jin, D., & Xing, B. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120093 · Cited by 322
Self-citationUpconversion-based photodynamic cancer therapy
Liu, Y., Meng, X., & Bu, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.006 · Cited by 319
Dąbrowski, J. M., Pucelik, B., Regiel-Futyra, A., Brindell, M., Mazuryk, O., Kyzioł, A., Stochel, G., Macyk, W., & Arnaut, L. G. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.06.007 · Cited by 317
Manipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)
Dang, J., He, H., Chen, D., & Yin, L. (2017) · Biomaterials Science · doi:10.1039/c7bm00392g · Cited by 317
Mitochondria‐Targeted Small‐Molecule Fluorophores for Dual Modal Cancer Phototherapy
Luo, S., Tan, X., Fang, S., Wang, Y., Liu, T., Wang, X., Yuan, Y., Sun, H., Qi, Q., & Shi, C. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600159 · Cited by 285
Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments
Kolarikova, M., Hosikova, B., Dilenko, H., Barton‐Tomankova, K., Valkova, L., Bajgar, R., Malina, L., & Kolarova, H. (2023) · Medicinal Research Reviews · doi:10.1002/med.21935 · Cited by 282
Feng, L., Li, C., Liu, L., Wang, Z., Chen, Z., Yu, J., Ji, W., Jiang, G., Zhang, P., Wang, J., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c10019 · Cited by 268
Self-citationYue, N.-N., Xu, H.-M., Xu, J., Zhu, M.-Z., Zhang, Y., Tian, C.-M., Nie, Y.-Q., Yao, J., Liang, Y.-J., Li, D.-F., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s413141 · Cited by 46
Self-citation
Metadata
- Authors
- Hou, Z., Zhang, Y., Deng, K., Chen, Y., Li, X., Deng, X., Cheng, Z., Lian, H., Li, C., & Lin, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-02-20
- Volume
- 9
- Issue
- 3
- Pages
- 2584-2599
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2008045805
- Cited by
- 570
- References
- 1
- FWCI
- 30.98
- Type
- journal article
- Language
- en
- Open access
- closed
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